Circadin contains synthesised Melatonin - a hormone released by the hypothalamus to induce and promote sleep, as per the circadian rhythm.
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Circadin is intended for those who suffer secondary insomnia. This condition is characterised as a chronic sleep disorder in which a person cannot initiate sleep, stay asleep, feels tired despite spending an adequate time asleep. Unlike primary insomnia, which can be treated with a change in lifestyle and sleep hygiene, the cause of secondary insomnia is often not known or based on the natural decrease in melatonin production in those over 55.
Circadin contains a synthetic version of the hormone Melatonin which is key in inducing and maintaining sleep. The Melatonin is formulated in a prolonged release tablet which allows a steady release over 8 to 10 hours. It is usually indicated for insomnia in patients over 55. However, it is safe and effective in temporary off-label use for jet lag induced insomnia.
The onset of natural sleepiness is felt within 2 hours. The prolonged release of melatonin enables a better quality and longer sleep.
Circadin contains 2 mg of a synthetic version of the naturally occurring hormone melatonin.
Melatonin is a key hormone released by the pineal gland in the brain to induce and promote sleep. The hypothalamus in the brain triggers the release of melatonin as per the regular circadian rhythm and in periods of diminished light exposure, such as evenings and during the night.
Melatonin levels during the day are low, gradually increasing throughout the evening, and peaking at around midnight.
After reaching its peak, the melatonin levels in the body begin to drop, allowing the body to wake naturally.
Circadin mimics this action by slowly releasing melatonin into the body shortly after ingestion.
Circadin helps to regulate your body clock by promoting a natural progression into sleep over the course of 8-10 hours by mimicking the melatonin in your body. Due to the way the synthesised melatonin works, withdrawal symptoms, dependence, tolerance, cognitive impairment and daytime sedation do no occur.
Unlike other Z-drugs, Circadin (Melatonin) does not cause immediate drowsiness, nor does it pose a risk of a come-down after the hormone is metabolised. While one of the side effects of Circadin is vivid dreaming, studies have shown that there is no causality between the levels of melatonin and the amount of REM sleep - the sleep stage in which you dream.
Take one slow-release tablet whole after food, 1 to 2 hours before you intend to go to bed. If crushed or broken, the slow release action may be reduced which could impact the efficacy of the drug and the quality of the sleep you experience. Circadin is absorbed slowly by the body to maintain a deep and restful sleep.
Circadin 2 mg is typically prescribed for 21 days. After the treatment period, it is advised to arrange an appointment with your doctor to review how the treatment worked for you.
Only take as directed at night and do not take during the day. Taking Circadin at the wrong time could shift your circadian rhythm undesirably, reducing the amount of night sleep or causing drowsiness during the day.
For optimum results, aim to go to bed at the same time each night, taking melatonin at the same time up to 2 hours before you go to sleep.
Do not consume alcohol while taking Circadin 2 mg as this can reduce the effectiveness of the medicine or cause undesired effects such as excessive drowsiness or restless sleep.
Other sleep inducing medications, such as the Benzodiazepines, can worsen the side effects or render the medicine ineffective.
Circadin is relatively safe and well tolerated. Clinical trials show that it has a low incidence of adverse effects. There is no evidence which states that it causes dependence or even the daytime effects as seen with other hypnotic medication. There is a low incidence of impaired daytime concentration and can even improve daytime functioning due to its ability to initiate a deep and restful sleep.
Note: Circadin must not be taken with other sleep drugs such as:
Please inform our Doctor if you are on any other medication, or suffer from other conditions such as:
It is not recommended taking this whilst you are Pregnant or Breastfeeding.
You may experience mild symptoms such as:
If you take more than the prescribed dose of Circadin, contact our doctor as soon as possible. Taking too much melatonin can make you feel drowsy. If you accidentally take too much Circadin, ensure you are in a safe place to sleep off the effects of the drug. Inform your doctor if this occurs.
During clinical trials, doses of Circadin (Melatonin) up to 300 mg showed no adverse reaction in participants. However, taking too much melatonin can have a negative impact on your quality of sleep.
Always read the patient information leaflet which comes with your medication before taking.
Westward flights can have a negative impact on staying asleep whilst eastward flights can cause trouble falling asleep. It is recommended to:
You can use Melatonin if you have a long overnight flight.
A Cochrane review from 2002 recognised melatonin as an effective treatment towards the treatment of jet lag.
Circadin treats the irregular sleeping patterns but not the cause of the condition. If treatment is stopped, you may not feel the benefits of taking the medication.
Studies did not indicate if rebound insomnia occurred in patients once they stopped taking Circadin.
Circadin has been rigorously trialled and tested to ensure it is safe and effective. Other melatonin supplements have not been tested and may contain varying amounts of unverified substances.
Proceed to fill in the short questionnaire and our Doctors are on hand to provide expert advice. Our GPHC registered Pharmacy will dispatch using discreet packaging via a next day delivery service.
Melatonin production in people over the age of 55 is typically slower. To combat this natural drop in melatonin, Circadin can release a synthetic replacement gradually in patients to slowly induce sleep.
While it can be prescribed to people under the age of 55, it is more common that people under this age threshold suffer primary insomnia linked to their diet and environment.
Circadin is metabolised very quickly and can be expected to leave the body within 12 hours after administration.
Whilst it may not be safe to drive shortly after taking Circadin, melatonin is not a controlled substance and will not impact blood, drug or breathalyser tests.
Circadin is not a sedative and you will not fall asleep immediately after taking the drug.
Within 2 hours of dosing, your body will prepare itself for a natural sleep.
If taken correctly, you should wake feeling refreshed and well rested. If you feel tired during the day after taking Circadin, talk to your doctor.
It is advised not to drive a car or use machinery up to 8 hours after taking Circadin. If you still feel sleepy in the morning after taking melatonin, it is strongly advised not to drive, ride a bike of use machinery.
If you take more than the recommended dosage, you may feel very sleepy. Make sure you are in a safe place to sleep off the effects. It will take 12 hours for the melatonin to exit your system. After which, you should avoid driving or using machinery.
There is little evidence to suggest that taking too much melatonin can cause significant harm, however, it is imperative that you inform your doctor if you accidentally take more than the prescribed dosage.
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