Circadin (Melatonin)

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  1. Click on the green "continue to medical questions" button.
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  5. If you get the green light and it is deemed suitable, your order will be processed quickly and efficiently.
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About Product
This content has been written and checked for quality and accuracy by
Mohamed Imran Lakhi Content Administrator GPhC: 2060586 Updated on: 31/01/2020 Next review: 31/07/2020

Circadin 2 mg (Melatonin)

Circadin is intended for those who suffer secondary insomnia. This condition is characterised as a chronic sleep disorder in which a person cannot initiate sleep, stay asleep, feels tired despite spending an adequate time asleep. Unlike primary insomnia, which can be treated with a change in lifestyle and sleep hygiene, the cause of secondary insomnia is often not known or based on the natural decrease in melatonin production in those over 55.

Circadin contains a synthetic version of the hormone Melatonin which is key in inducing and maintaining sleep. The Melatonin is formulated in a prolonged release tablet which allows a steady release over 8 to 10 hours. It is usually indicated for insomnia in patients over 55. However, it is safe and effective in temporary off-label use for jet lag induced insomnia.

The onset of natural sleepiness is felt within 2 hours. The prolonged release of melatonin enables a better quality and longer sleep.

You can buy Circadin 2mg online from Prescription Doctor's secure online pharmacy. Our online prescribers are on hand to make sure that Circadin is safe for you. To begin your order, simply complete our medical form.

How Does Circadin 2 mg (Melatonin) Work?

Circadin contains 2 mg of a synthetic version of the naturally occurring hormone melatonin.

Melatonin is a key hormone released by the pineal gland in the brain to induce and promote sleep. The hypothalamus in the brain triggers the release of melatonin as per the regular circadian rhythm and in periods of diminished light exposure, such as evenings and during the night.

Melatonin levels during the day are low, gradually increasing throughout the evening, and peaking at around midnight.

After reaching its peak, the melatonin levels in the body begin to drop, allowing the body to wake naturally.

Circadin mimics this action by slowly releasing melatonin into the body shortly after ingestion.

What Are The Benefits Of Circadin?

Circadin helps to regulate your body clock by promoting a natural progression into sleep over the course of 8-10 hours by mimicking the melatonin in your body. Due to the way the synthesised melatonin works, withdrawal symptoms, dependence, tolerance, cognitive impairment and daytime sedation do no occur.

Unlike Z-drugs, Circadin (Melatonin) does not cause immediate drowsiness, nor does it pose a risk of a come-down after the hormone is metabolised. While one of the side effects of Circadin is vivid dreaming, studies have shown that there is no causality between the levels of melatonin and the amount of REM sleep - the sleep stage in which you dream.

How To Take Circadin?

Take one slow-release tablet whole after food, 1 to 2 hours before you intend to go to bed. If crushed or broken, the slow release action may be reduced which could impact the efficacy of the drug and the quality of the sleep you experience. Circadin is absorbed slowly by the body to maintain a deep and restful sleep.

Circadin 2 mg is typically prescribed for 21 days. After the treatment period, it is advised to arrange an appointment with your doctor to review how the treatment worked for you.

Only take as directed at night and do not take during the day. Taking Circadin at the wrong time could shift your circadian rhythm undesirably, reducing the amount of night sleep or causing drowsiness during the day.

For optimum results, aim to go to bed at the same time each night, taking melatonin at the same time up to 2 hours before you go to sleep.

Do not consume alcohol while taking Circadin 2 mg as this can reduce the effectiveness of the medicine or cause undesired effects such as excessive drowsiness or restless sleep.

Other sleep inducing medications, such as the Benzodiazepines, can worsen the side effects or render the medicine ineffective.

Staying Safe With Prescription Doctor

Circadin is relatively safe and well tolerated. Clinical trials show that it has a low incidence of adverse effects. There is no evidence which states that it causes dependence or even the daytime effects as seen with other hypnotic medication. There is a low incidence of impaired daytime concentration and can even improve daytime functioning due to its ability to initiate a deep and restful sleep.

Note: Circadin must not be taken with other sleep drugs such as:

  • Benzodiazepines
  • Zolpidem
  • Zopiclone
  • Zaleplon

Please inform our Doctor if you are on any other medication, or suffer from other conditions such as:

  • Liver/Kidney impairment
  • Diabetes
  • Lactose Intolerance
  • Autoimmune diseases.

Pregnancy and breastfeeding

It is not recommended taking this whilst you are Pregnant or Breastfeeding.

For more information regarding the safety of Circadin during pregnancy and breastfeeding, speak to your doctor.

Side effects

All medications carry the risk of side effects, though not everybody experiences them. It's important to familiarise yourself with the safety information found in the pamphlet which is supplied with your medicine.

Circadin is usually well tolerated.

Uncommon side effects (may affect up to 1 in 100 people):

  • Abnormal dreams
  • Anxiety
  • Dizziness
  • Dry mouth
  • Fatigue
  • Headache
  • High blood pressure
  • Indigestion
  • Insomnia
  • Irritability
  • Migraine
  • Nausea
  • Nausea
  • Nervousness
  • Nightmares
  • Restlessness
  • Upper abdominal pain

This is not an exhaustive list of side effects. Further information regarding the safety of Circadin can be found within the patient information leaflet.

You can view the patient information leaflet for Circadin online here.

During clinical trials, doses of Circadin (Melatonin) up to 300 mg showed no adverse reaction in participants. However, taking too much melatonin can have a negative impact on your quality of sleep.

Other cautions

Always seek your doctor's advice before you buy Circadin online.

Do not take Circadin past the expiry date printed on the packaging.

Never throw away medicine away via household or water waste. Take any unwanted or expired medicine to your pharmacy for them to dispose of safely.

Always keep medicine out of the sight and reach from children and pets.

Further Advice Before You Buy Circadin

Westward flights can have a negative impact on staying asleep whilst eastward flights can cause trouble falling asleep. It is recommended to:

  • Stay awake during daylight - light exposure can help to adjust.
  • Go outside in the sunlight in the afternoon if possible.
  • After dusk, it starts to get darker, it is best to plan to sleep soon after.
  • Take Circadin as directed a few hours before you plan to sleep in the evening.

You can use Melatonin if you have a long overnight flight.

A Cochrane review from 2002 recognised melatonin as an effective off-label treatment towards the treatment of jet lag.

Circadin treats the irregular sleeping patterns but not the cause of the condition. If treatment is stopped, you may not feel the benefits of taking the medication.

Studies did not indicate if rebound insomnia occurred in patients once they stopped taking Circadin.

Why Buy Circadin Online?

Circadin has been rigorously trialled and tested to ensure it is safe and effective. Other melatonin supplements have not been tested and may contain varying amounts of unverified substances.

Proceed to fill in the short questionnaire and our Doctors are on hand to provide expert advice. Our GPHC registered Pharmacy will dispatch using discreet packaging via a next day delivery service.

Frequently Asked Questions

What should I do if I forget to take Circadin when I should?

If you forget to take Circadin, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and take your next dose at the usual time.

Do not take more Circadin to make up for the dose you missed.

What should I do if I take more Circadin than I should?

If you take more than the recommended dosage, you may feel very sleepy. Make sure you are in a safe place to sleep off the effects. It will take 12 hours for the melatonin to exit your system. After which, you should avoid driving or using machinery until you feel well enough to do so.

There is little evidence to suggest that taking too much melatonin can cause significant harm, however, it is imperative that you inform your doctor if you accidentally take more than the prescribed dosage.

Why is Circadin only recommended for people over the age of 55?

Melatonin production in people over the age of 55 is typically slower. To combat this natural drop in melatonin, Circadin can release a synthetic replacement gradually in patients to slowly induce sleep.

While it can be prescribed to people under the age of 55, it is more common that people under this age threshold suffer primary insomnia linked to their diet and environment.

How long does it take for Circadin (melatonin) 2 mg to leave the body?

Circadin is metabolised very quickly and can be expected to leave the body within 12 hours after administration.

Whilst it may not be safe to drive shortly after taking Circadin, melatonin is not a controlled substance and will not impact blood, drug or breathalyser tests.

Will Circadin make me drowsy?

Circadin is not a sedative and you will not fall asleep immediately after taking the drug.

Within 2 hours of dosing, your body will prepare itself for a natural sleep.

If taken correctly, you should wake feeling refreshed and well rested. If you feel tired during the day after taking Circadin, talk to your doctor.

Can I drive after taking Circadin 2 mg?

It is advised not to drive a car or use machinery up to 8 hours after taking Circadin. If you still feel sleepy in the morning after taking melatonin, it is strongly advised not to drive, ride a bike of use machinery.

Can I buy Circadin online?

You can buy Circadin online from Prescription Doctor's safe and secure online pharmacy. Our online prescribers are on hand to determine whether Circadin is suitable for you.

All items are dispensed and dispatched from our UK registered pharmacy. We take great care to ensure your privacy when buying medicine online.

Table of contents

Circadin 2 mg

How does Circadin work?

What are the benefits of Circadin?

How to take Circadin?

Staying safe with Prescription Doctor

Further advice before you buy Circadin

Why buy Circadin online?

Frequently Asked Questions

Additional resources

Ways to improve your sleep

More about Jet Lag

Treatment information

  • Product Name: Circadin
  • Active Ingredient(s): Melatonin
  • Manufacturer: Lundbeck
  • Administration: Oral
  • Presentation: White round biconvex shaped tablets
  • Available Strength: 2 mg prolonged-release
  • Exemption: Prescription only medication
  • Application: Men and women
  • Dosage: 2 mg once daily, 1-2 hours before bedtime and after food.
  • Description: Circadin is used on its own for the short-term treatment of primary insomnia
  • Alcohol consumption: Avoid alcohol consumption
  • When pregnant: Do not take Circadin if you are pregnant
  • When breastfeeding: Do not take Circadin if you are breastfeeding
Click here to view the Circadin (Melatonin) - Patient Information Leaflet