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Wegovy

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Reviews
Treatment Information

Table of contents

What is Wegovy?

Wegovy, which contains the active ingredient semaglutide, is a revolutionary weight loss injection that offers a clinically proven approach to managing obesity. Developed by Novo Nordisk, this once-a-week injectable treatment is designed to regulate appetite and metabolism, providing a targeted solution for sustainable weight loss.

Obesity affects 1 in 4 adults in England, leading to various health issues such as cardiovascular illness, diabetes, and certain cancers. The National Health Service (NHS) spends a significant amount each year on treating obesity-related conditions.

Wegovy is an injectable treatment designed to assist with weight loss. Manufactured by Novo Nordisk, the same company behind Saxenda and Ozempic, Wegovy is administered once a week using pre-filled injection pens.


Is Wegovy UK Effective for Weight Loss?

Clinical trials have shown that Wegovy is highly effective for weight management. In a 68-week trial, people using Wegovy lost a significant amount of weight compared to those on a placebo. The Wegovy group had an average weight loss of 14.9%, while the placebo group only saw a 2.4% change.

Additionally, the trial found that an impressive 83.5% of Wegovy users achieved a weight loss of 5% or more of their body weight after 68 weeks, while only 31.1% in the placebo group reached a similar level of weight loss. Another clinical trial also showed significant weight reduction with Wegovy compared to a placebo.

These outstanding trial results have led the National Institute for Health and Care Excellence (NICE) to recommend Wegovy for managing obesity. These positive findings support Wegovy as an effective option for achieving weight loss goals.


Expected Weight Loss and Duration of Wegovy UK Treatment

According to NICE, adults using Wegovy typically experience an average weight loss of 12% of their body weight.

The duration for Wegovy to take effect can vary from person to person due to individual differences in response to medication.


Understanding How Wegovy (Semaglutide) Works

Wegovy's active ingredient is semaglutide, a glucagon-like peptide 1 (GLP-1) analogue. Semaglutide functions by increasing insulin production, which helps regulate blood sugar levels. Additionally, it slows down stomach emptying, leading to a prolonged feeling of fullness and reduced appetite.

Semaglutide has also shown potential in preventing cardiovascular events in individuals with type-2 diabetes, such as heart disease and stroke.

To achieve optimal results, Wegovy should be used alongside a healthy, low-calorie diet and regular exercise.


How to Administer Wegovy (Semaglutide)

Wegovy is a self-administered medication that you inject just under your skin using a concealed needle in a pen. Each pen has multiple doses depending on your schedule and comes with replaceable needles.

To use it, remove the cap, press the pen against your skin, and the needle will automatically cover itself afterward. Dispose of used pens in a sharps bin and change the needle each time.

Check the solution in the pen before use; if it's not clear and colourless, get a new pen. You can take Wegovy at any time, with or without food, but try to stick to the same day each week.

Inject it into your abdomen, thigh, or upper arm, rotating the injection site weekly. Store Wegovy in the fridge, between 2°C and 8°C, for up to 28 days. Keep it away from children and pets, and always dispose of used pens in a designated sharps bin, not regular household waste.

Dosage Schedule

The Wegovy dose is increased every 4 weeks over a period of 16 weeks. Initially, patients take a 0.25mg once-weekly dose for the first 4 weeks. Then, the dose is gradually increased until reaching the maintenance dose of 2.4mg once weekly starting from week 17. This gradual increase is important to minimize the risk of side effects, which are more likely to occur during the dose-escalation phase but tend to improve over time.

Wegovy (Semaglutide) should be injected once a week on the same day each week. It can be taken at any time of day, with or without meals. The injection should be administered subcutaneously into the abdomen, thigh, or upper arm.

The dosage schedule for Wegovy is as follows:

  • Weeks 1-4: 0.25mg (Green pen)
  • Weeks 5-8: 0.5mg (Pink pen)
  • Weeks 9-12: 1mg (Brown pen)
  • Weeks 13-16: 1.7mg (Blue pen)
  • Week 17 onwards: 2.4mg (Black pen)

 


Who is Eligible for Wegovy Treatment in the UK?

Wegovy is suitable for adults between the ages of 18 and 75 who meet the following criteria:

Eligibility Criteria:

  1. Body Mass Index (BMI) of 30 or higher,
  2. BMI of 27 or higher, accompanied by a weight-related medical condition.

Exclusion Criteria:

You are not eligible for Wegovy if you:

  • Are aged 76 or older
  • Are currently pregnant or breastfeeding
  • Suffer from liver, kidney, or heart failure
  • Have an eating disorder or pancreatitis
  • Are on insulin, sulphonylureas, or other weight-loss medications that function similarly to Wegovy, such as Victoza.

 


Missed Wegovy Doses and Accidental Use

If you forget to take Wegovy and your next dose is due in more than two days, use Wegovy as soon as possible. However, if less than two days remain until your next dose, skip the missed dose and continue with your regular dosage schedule.

Accidentally using two Wegovy pens in one week can lead to severe side effects such as intense nausea, vomiting, and dangerously low blood sugar levels. If this occurs, go to the nearest accident and emergency department immediately, taking the packaging and any remaining medicine with you.


Wegovy Contraindications & Drug Interactions

  • Allergy: Do not use Wegovy if you have had an allergic reaction to semaglutide or any of the other ingredients in the injection.
  • Digestive System Side Effects: Wegovy can cause digestive system side effects such as vomiting and diarrhea. It is important to stay hydrated to reduce the risk of dehydration, especially for individuals with kidney problems.
  • Pancreatitis: Although uncommon, pancreatitis may be experienced as a side effect. If you notice severe stomach pain or other symptoms of pancreatitis, stop using Wegovy and seek medical attention immediately. For more information on pancreatitis symptoms, refer to the NHS website.
  • Diabetes: Wegovy should not be used as a substitute for insulin in people with diabetes. It can also increase the risk of low blood sugar levels when taken with other diabetic medicines. Please refer to section 2 of the patient information leaflet for a complete list of warnings.
  • Diabetic Retinopathy: This medication is not suitable for individuals experiencing diabetic retinopathy. Consult your doctor before using Wegovy if this applies to you.

Wegovy (Semaglutide) and Pregnancy

  • Pregnancy: Wegovy should not be used during pregnancy as it may harm the fetus. It is advised to stop using Wegovy at least 2 months before planning a pregnancy.
  • Breastfeeding: Do not use Wegovy if you are breastfeeding.

Wegovy (Semaglutide) Side Effects

Common Side Effects of Wegovy:

  • Headache
  • Vomiting
  • Diarrhea
  • Constipation
  • Nausea
  • Abdominal pain
  • Fatigue

Improvement over Time:

  • Side effects usually improve as the body becomes accustomed to the medication.
  • Gradually increasing the dose every 4 weeks can help reduce the risk of experiencing these side effects.

Severe Side Effects:

  • If your side effects are severe or do not improve, consult your doctor or pharmacist for advice or call NHS 111.

Complete List of Side Effects:

  • For a comprehensive list of possible side effects, please refer to section 4 of the patient information leaflet.

Wegovy with Next-Day Delivery

Wegovy (Semaglutide) through Prescription Doctor ensures that you receive genuine medication from a trusted source. Our platform offers a seamless experience, from online consultation to next-day delivery, making it easier for you to manage your weight loss journey.


Frequently Asked Questions (FAQs) About Wegovy (Semaglutide) UK

Can Wegovy (Semaglutide) Be Used During Pregnancy or While Breastfeeding?

Wegovy (Semaglutide) should not be used if you are pregnant, think you might be pregnant or are breastfeeding. Stop using Wegovy two months before planning to become pregnant.

Can I Consume Alcohol While Using Wegovy (Semaglutide)?

It is advisable to limit alcohol consumption while using Wegovy for weight loss. Alcoholic beverages can be high in calories and counterproductive to weight loss efforts.

Is Wegovy the Same as Ozempic?

Wegovy and Ozempic contain the same active ingredient, semaglutide. However, they differ in dosage and pen type.

What Should I Eat While on Wegovy (Semaglutide)?

It is recommended to follow a balanced and healthy diet while taking Wegovy. Limit the consumption of foods high in salt, sugar, and fat, and moderate your alcohol intake to reduce overall calorie intake.

How Many Wegovy (Semaglutide) Pens Are Needed to Reach the Maintenance Dose?

To reach the maintenance dose of 2.4mg per week, you will need to use 16 Wegovy doses in a gradually increasing dosage schedule.

How Much Weight Can I Lose on Wegovy in the UK?

In clinical trials, people with a BMI of 27 or greater lost an average of 12% of their body weight over 68 weeks. This is equivalent to about 26 pounds.

How Long Does It Take to See Results with Wegovy (Semaglutide) in the UK?

Some people start to see results within the first few weeks, but it may take up to 12 weeks to see the full effect.

Is Wegovy (Semaglutide) Safe for Everyone?

Wegovy (Semaglutide) is not safe for everyone. It should not be used by people with a history of pancreatitis or thyroid problems. It should also be used with caution in people with type 1 diabetes.

How Long Can a Wegovy Pen Be Stored Once Opened?

An opened Wegovy pen remains usable for 6 weeks, whether stored at room temperature or in the fridge.

Can I Take Wegovy (Semaglutide) with Other Weight Loss Drugs?

Wegovy (Semaglutide) should not be taken with other weight loss drugs, such as Saxenda or Ozempic. This can increase the risk of side effects.

What Are the Storage Guidelines for Wegovy Pens?

Unopened pens: Store in fridge between 2°C & 8°C, away from the cooling element. Opened pens: Store at room temp below 30°C or in the fridge between 2°C & 8°C for up to 6 weeks. Check the expiry date before use. 

 

Authored By

Dr Giuseppe
Dr. Giuseppe utilises his extensive experience in general practice to ensure the accuracy and safety of the website's content.

Published on: 16/02/2022

Reviewed By

Mohamed Imran Lakhi

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Reviewed on: 21/12/2023

Treatment information

  • Product Name: Wegovy
  • Manufacturer: Novo Nordisk
  • Active Ingredient(s): Semaglutide
  • Administration: Subcutaneous injection
  • Presentation: Injectable solution
  • Available Strength: 0.25, 0.5, 1.0, 1.7, 2.0 mg
  • Exemption: Prescription Only
  • Dosage: Once a week
  • Description: Wegovy is a weekly injection that aids weight loss
  • Drug Class: GLP-1 analogue
  • Alcohol Consumption: Avoid or limit alcohol consumption
  • When Pregnant: Do not take Wegovy if you are pregnant
  • Price: 199.99 GBP
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Click here to view the Wegovy - Patient Information Leaflet
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