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Order now to receive your order Tuesday, January 31
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  1. Click on the green "Start Order" button.
  2. Fill in our short consultation form.
  3. Choose delivery method and mode of payment.
  4. Our team of expert prescribers will assess whether medication is suitable.
  5. If you get the green light and it is deemed suitable, your order will be processed quickly and efficiently.
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Your privacy is important, Prescription Doctor are committed to keeping your details completely confidential.

This is why we also take steps to conceal your prescription products under two layers of packaging.

Delivery and Packing
Discreet Delivery?

We have a commitment to delivering a discreet service and understand your need for privacy. We ship all orders via a trackable courier using discreet, plain packaging.

Do I Need to Wait in All Day for Delivery?

Once your order is dispatched you will receive a tracking number via sms and email.

Do You Deliver on Weekends?

We deliver medications between Monday and Saturday. You can upgrade to Saturday delivery on Friday.

My Order Hasn’t Arrived What Should I Do?

You should receive a tracking number with your order which you can use this number to track your parcel online. This should give you a clear indication of where your parcel is. If you haven’t received your parcel in the time frame given by our couriers, contact your local depot to find out where it is. You can also contact our support team who will do this for you.

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On checkout you will be asked to leave your mobile number so our courier can text you about the delivery. This is also useful if the courier has problems finding your address. We will not use your mobile number for anything else.

Payment Methods
How Can I Pay for My Order?

You can pay for your order using credit, debit card or via bank transfer.

I Don’t Have a Credit Card, How Can I Pay?

If you don’t have a credit or debit card you can pay via bank transfer. We will give you a unique reference number at checkout along with details of how to make the transfer. Once the money has cleared in our account, we will process your order.

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We are a completely secure site and take many measures to ensure your details are kept safe. We understand that you have a right to extreme privacy when purchasing sensitive health medications. All information that you provide to us is stored on our secure servers. Any payment transactions will be encrypted using SSL technology.

Payment and refunds?

You can pay for your order using credit, debit card and bank transfer.

Card Payment: Please notify us that you wish to cancel your order. Your refund will show available In 1 - 3 days.

Bank Transfer: A member of our team will contact you requesting for your bank details. These details are only used to transfer the funds back into your account.

About Product
Adil Bhaloda
This content has been checked for quality and accuracy by
Adil Bhaloda Pharmacist

Buy Mysimba in UK

To begin your weight loss journey with PrescriptionDoctor, as part of the consultation, you shall be asked several medical questions formulated by our health professionals.

As part of the consultation, you shall be asked to provide evidence of your current weight. This helps our prescribers to ensure a confirmed baseline weight to work from.

As part of your weight loss journey, you shall have access to our healthcare professionals if you have questions regarding your health or treatment.

What Is Mysimba - Slimming Pills for Weight Loss

Mysimba is a weight loss medicine which contains the active ingredients naltrexone and bupropion. When combined with a low-calorie diet and physical exercise, Mysimba can help you shed unhealthy weight.

According to the NHS, approximately 29% of adults in England are obese and more than a third of the population is overweight.

Classification of whether a person is overweight or obese is defined by their body mass index (BMI).

A BMI of 25 - 30 is overweight, while a BMI greater than 30 is obese.

You can work out your BMI using the NHS Online BMI Calculator.

How does Mysimba work?

How Mysimba UK works is not yet fully understood. According to European Medicine Agency, the two active substances, naltrexone and bupropion, act on the parts of the brain that control food intake and energy balance, as well as reducing the effect of the part of the brain that controls the pleasure associated with eating food.

So far, studies have indicated that Mysimba can reduce body weight by at least 5% over the course of 28 to 56 weeks when taken alongside a healthy diet and regular exercise.

How diet and exercise affect Mysimba

While taking any weight loss treatment, it is essential to eat a healthy, balanced and nutritious diet low in saturated fat.

Regular exercise is also key to weight loss goals. Taking up a sport or any recreational activity which requires physical exertion, such as running or dancing, can help immensely.

You should consider keeping a food diary to track your eating habits and exercise regime. This can help you and your doctor to identify areas of your lifestyle you need to improve. For instance, you could be eating too much of a specific food group or not exercising enough.

It's best to speak to our online prescriber or a nutritionist for advice on dieting and exercising.

How to take Mysimba?

Mysimba is taken at increasing doses.

Week No. Dose
Week 1 Take one tablet every morning
Week 2 Take one tablet in the morning and one tablet in the evening
Week 3 Take two tablets in the morning and one tablet in the evening
Week 4 and onward Take two tablets in the morning and two tablets in the evening.


Swallow each Mysimba tablet whole with a glass of water.

You should take Mysimba tablets with food.

Do not crush, cut or chew the tablets.

After 16 weeks of taking Mysimba, and after each year of treatment, our prescriber will decide whether you should continue taking Mysimba.

What should I do if I forget to take Mysimba?

If you forget to take Mysimba, skip the missed dose and continue to take Mysimba as usual.

Do not take more Mysimba to make up for the missed dose.

What should I do if I take too much Mysimba?

If you take more Mysimba than you should, contact your doctor or go straight to your nearest A&E department.

Taking more Mysbima than is recommended can increase your risk of experiencing severe side effects, such as seizures.

Mysimba side effects and cautions


Mysimba may interact with the medicine you are currently taking for other conditions. It is vital to inform our prescriber of all the medications you are currently taking before you start taking Mysimba.

The two active ingredients of Mysimba may interact with other medicines you are taking:

Bupropion the 1st active interdient in Mysimba

  • Almotriptan  -  Bupropion might enhance the risk of serotonin syndrome.
  • Amitriptyline - Bupropion is predicted to increase exposure to Amitriptyline.
  • Atomoxetine - Bupropion is predicted to markedly increase exposure to Atomoxetine.
  • Carbamazepine - Carbamazepine is predicted to markedly decrease exposure to Bupropion.

This is not a complete list of interactions. To view a comprehensive list, visit NICE interactions.

Naltrexone is the 2nd active ingredient in Mysimba

  • Alfentanil - Naltrexone is predicted to decrease the efficacy of Alfentanil.
  • Buprenorphine - Naltrexone is predicted to decrease the efficacy of Buprenorphine.

This is not a complete list of interactions. To view a comprehensive list, visit NICE interactions.

Do not take Mysimba if you are currently taking:

Monoamine oxidase inhibitors - (used to treat depression or Parkinson's disease) such as phenelzine, selegiline or rasagiline.

Opiates and opiate-containing medicines - including some cough syrups (codeine linctus), medicines to treat addiction (methadone), pain relief (Codeine and morphine), and diarrhoea (paregoric).

Inform our online prescribers of all medicines you are currently taking, including medicines prescribed by your doctor and those bought over the counter, as well as health and herbal supplements.

Side effects

Every medicine carries the risk of side effects, though not everybody gets them. Understanding the risks associated with your medicine is vital to your care.

Very common side effects of taking Mysimba include:

  • Abdominal pain
  • Agitation
  • Anxiety
  • Being sick (Vomiting)
  • Constipation
  • Difficulty sleeping (avoid taking Mysimba near bedtime)
  • Feeling sick (nausea)
  • Headache
  • Pain in the joints and muscles

This is not an exhaustive list of side effects. Further information regarding the safety of Mysimba, including a complete list of side effects, can be found within the patient information leaflet enclosed with your medicine.

If you experience any side effects, regardless of whether they are listed above, in the patient information leaflet or otherwise, inform your doctor.

Allergic reaction

Do not take Mysimba if you are allergic to naltrexone hydrochloride, bupropion hydrochloride, or other ingredients listed in the patient information leaflet.

Mysimba contains lactose. If you have been told by your doctor that you are sensitive to some sugars (i.e. lactose intolerant), speak to your doctor before taking Mysimba.

If you experience an allergic reaction while taking Mysimba, stop and seek emergency medical attention. In cases of an extreme allergic reaction, go straight to your nearest casualty department.

Signs of an allergic reaction include:

  • Dry, red, and cracked skin
  • Itching, red, watery eyes
  • Red, itchy, raised rash (hives)
  • Swelling of the lips, tongue, eyes or face
  • Tightness of the chest
  • Tummy pain, nausea, vomiting or diarrhoea
  • Wheezing

Pregnancy and breastfeeding

Do not take Mysimba if you are pregnant or breastfeeding.

If you are pregnant, breastfeeding, think you might be pregnant or planning on having a baby soon, speak to your doctor or a pharmacist before taking Mysimba.

If you become pregnant while taking Mysimba, speak to your doctor as soon as possible.

Other safety information

If you have questions about Mysimba or weight loss, you can speak to one of our online doctors using the online messaging system under your account.

Do not take Mysimba past the expiry date printed on the packaging. The date refers to the last day of that month - for example, "EXP: 03/20" means the 31st of March 2020.

Do not throw away unwanted or expired medicine via household or water waste. Take all unwanted and expired medicine to your pharmacy and ask them to dispose of it safely on your behalf.

Always store medicine out of sight and reach from children and pets.

Never share your medicine with anybody else, even if they are experiencing the same symptoms as you.

Frequently asked questions

How effective is Mysimba?

In studies, more than 40% of people taking Mysimba lost 5% of their body weight over the course of 28 or 56 weeks.

Can I drink alcohol while taking Mysimba?

You should avoid or limit alcohol consumption while taking Mysimba for weight loss. Alcoholic drinks are generally high in calories and can put you at an increased risk of complications from obesity.

Will Mysimba affect my ability to drive or operate machinery?

Mysimba may cause you to feel drowsy or dizzy. If you notice that this medicine has this effect on you, you should avoid driving or operating any machinery until you are well enough to do so.

Is Mysimba available on the NHS?

No, Mysimba is not typically available on the NHS. However, it is available from Prescription Doctor's online private prescription service.

Simply fill out our short medical questionnaire, and our online prescriber will determine whether Mysimba is suitable for you.

How long can I take Mysimba?

You should take Mysimba for at least 16 weeks in order for it to reach its maximum effect.

Mysimba can be taken for as long as required to achieve your weight loss goal. You should not stop taking Mysimba without first speaking to your doctor.

Can I use Mysimba alongside other weight loss treatments, like Orlistat or Saxenda?

Do not use Mysimba together with Orlistat or Saxenda. If you wish to change the weight loss medication you are taking, speak to your doctor.

Treatment information

  • Product Name: Mysimba
  • Manufacturer: Orexigen Therapeutics
  • Active Ingredient(s): Naltrexone hydrochloride and bupropion hydrochloride
  • Administration: Oral
  • Presentation: Tablet
  • Available Strength: 8mg/90mg
  • Exemption: Prescription Only
  • Application: Adults with a BMI above 30
  • Dosage: Take as prescribed by the doctor
  • Alcohol Consumption: Avoid or limit alcohol consumption
  • When Pregnant: Do not take Mysimba during pregnancy. Speak to your doctor for further advice.
  • When Breastfeeding: Do not take Mysimba while breastfeeding. Speak to your doctor for further advice.
Click here to view the Mysimba - Patient Information Leaflet

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