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How to order
  1. Click on the green "Start Order" button.
  2. Fill in our short consultation form.
  3. Choose delivery method and mode of payment.
  4. Our team of expert prescribers will assess whether medication is suitable.
  5. If you get the green light and it is deemed suitable, your order will be processed quickly and efficiently.
Confidential Service

Your privacy is important, Prescription Doctor are committed to keeping your details completely confidential.

This is why we also take steps to conceal your prescription products under two layers of packaging.

Delivery and Packing
Discreet Delivery?

We have a commitment to delivering a discreet service and understand your need for privacy. We ship all orders via a trackable courier using discreet, plain packaging.

Do I Need to Wait in All Day for Delivery?

Once your order is dispatched you will receive a tracking number via sms and email.

Do You Deliver on Weekends?

We deliver medications between Monday and Saturday. You can upgrade to Saturday delivery on Friday.

My Order Hasn’t Arrived What Should I Do?

You should receive a tracking number with your order which you can use this number to track your parcel online. This should give you a clear indication of where your parcel is. If you haven’t received your parcel in the time frame given by our couriers, contact your local depot to find out where it is. You can also contact our support team who will do this for you.

Can I Be Notified by Text?

On checkout you will be asked to leave your mobile number so our courier can text you about the delivery. This is also useful if the courier has problems finding your address. We will not use your mobile number for anything else.

Payment Methods
How Can I Pay for My Order?

You can pay for your order using credit, debit card or via bank transfer.

I Don’t Have a Credit Card, How Can I Pay?

If you don’t have a credit or debit card you can pay via bank transfer. We will give you a unique reference number at checkout along with details of how to make the transfer. Once the money has cleared in our account, we will process your order.

How Do You Keep My Details Safe?

We are a completely secure site and take many measures to ensure your details are kept safe. We understand that you have a right to extreme privacy when purchasing sensitive health medications. All information that you provide to us is stored on our secure servers. Any payment transactions will be encrypted using SSL technology.

Payment and refunds?

You can pay for your order using credit, debit card and bank transfer.

Card Payment: Please notify us that you wish to cancel your order. Your refund will show available In 1 - 3 days.

Bank Transfer: A member of our team will contact you requesting for your bank details. These details are only used to transfer the funds back into your account.

About Product
This content has been written and checked for quality and accuracy by
Mohamed Imran Lakhi Content Administrator GPhC: 2060586 Updated on: 26/05/2020 Next review: 26/11/2020

What is Mysimba?

Mysimba is a weight loss medicine which contains naltrexone and bupropion. When taken adjacent to a low calorie diet and physical exercise, Mysimba can help you shed those extra pounds.

Obesity in the UK is on the increase, with an estimated 29% of adults in England being classed as obese, and more than a third of the population being classed as overweight, according to figures from the NHS.

Classification of whether a person is overweight or obese is defined by their body mass index (BMI).

A BMI of between 25 and 30 is classed as overweight, while a BMI greater than 30 is classed as obese.

You can work out your BMI using the NHS' Online BMI Calculator.

How does Mysimba work?

The mechanism of Mysimba is not fully understood in medical literature, though it is believed that naltrexone and bupropion affect how the brain manages food intake and the expenditure of energy (how calories are burned).

Despite this lack of understanding, studies have indicated that Mysimba can reduce body weight by at least 5% over the course of 28 to 56 weeks, when taken alongside a healthy diet.

How diet and exercise affect Mysimba

While taking any weight loss treatment, such as Mysimba, it's important to eat a healthy, balanced and nutritious diet which is low in saturated fat and triglycerides.

Regular exercise is also key to weight loss goals. Taking up a sport or any recreational activity which requires physical exertion, such as running or dancing, can help immensely.

How to take Mysimba?

Mysimba is taken at increasing doses.

Week No. Dose
Week 1 Take 1 tablet every morning
Week 2 Take 1 tablet in the morning and 1 tablet in the evening
Week 3 Take 2 tablets in the morning and 1 tablet in the evening
Week 4 and onward Take 2 tablets in the morning and 2 tablets in the evening


After 16 weeks of taking Mysimba, and after each year of treatment, your doctor will decide whether you should continue taking Mysimba.


Swallow each tablet whole - do not cut or chew them. You should take Mysimba tablets with food.

Side effects and cautions


Mysimba may interact with medicine you are currently taking for other conditions. It is important to inform our doctor of all the medications you are currently taking before you use Mysimba - this includes medicines bought over-the-counter, including health supplements, and those medicines which have been prescribed to you by your doctor.

Do not take Mysimba if you are currently taking:

Monoamine oxidase inhibitors - (used to treat depression or Parkinson's disease) such as phenelzine, selegiline or rasagiline.

Opiates and opiate containing medicines - including some cough syrups (codeine linctus), medicines to treat addiction (methadone), pain relief (Codeine and morphine), diarrhoea (peregoric). You must stop taking opiate medication at least 7 to 10 days before starting Mysimba. Once you stop taking Mysimba, you may be more sensitive to the effects of low doses of opiates.

Side effects

Every medicine carries the risk of side effects, though not everybody gets them. Understanding the risks associated with your medicine is vital to your care.

Very common side effects (may affect more than 1 in 10 people):

  • Abdominal pain
  • Aggitation
  • Anxiety
  • Being sick (Vomiting)
  • Constipation
  • Difficulty sleeping (make sure not to take Mysimba near to bedtime)
  • Feeling sick (nausea)
  • Headache
  • Pain in the joints and muscles

This is not an exhaustive list of side effects. Further information regarding the safety of this medication, including a complete list of side effects, can be found within the patient information leaflet enclosed with your medicine.

Alternatively, you can view the patient information leaflet for Mysimba here.

If you experience any side effects, regardless of whether they are listed above, in the patient information leaflet, or otherwise, inform your doctor.

Allergic reaction

Do not take Mysimba if you are allergic to naltrexone hydrochloride, bupropion hydrochloride, or any of the other excipients listed in the patient information leaflet.

If you experience an allergic reaction while taking Mysimba, cease taking the medicine and seek emergency medical attention.

Signs of an allergic reaction include:

  • Dry, red, and cracked skin
  • Itching, red, watery eyes
  • Raised, itchy, red rash (hives)
  • Swelling of the lips, tongue, eyes or face
  • Tightness of the chest
  • Tummy pain, nausea, vomiting or diarrhoea
  • Wheezing

Pregnancy and breastfeeding

Do not take Mysimba if you are pregnant or breastfeeding.

If you are pregnant, breastfeeding, think you might be pregnant or planning on having a baby in the near future, speak to your doctor or a pharmacist before taking Mysimba.

Other safety information

Always seek your doctor's advice before you buy Mysimba online.

Do not take Mysimba past the expiry date printed on the packaging. The date refers to the last day of that month - for example, "EXP: 03/20" means the 31st of March 2020.

Do not throw away unwanted or expired medicine via household or water waste. Take all unwanted and expired medicine to your pharmacy and ask them to dispose of it safely on your behalf.

Always keep medicine out of sight and reach from children and pets.

Never share your medicine with anybody else, even if they are experiencing the same symptoms as you.

Frequently asked questions

What should I do if I forget to take Mysimba when I should?

If you forget to take Mysimba, skip the missed dose and continue to take Mysimba as normal. Do not take more Mysimba to make up for the missed dose.

What should I do if I take too much Mysimba?

If you take more Mysimba than you should, contact your doctor or go straight to your nearest A&E department. Take the medicine packaging with you so doctors can ascertain what you took and how much you took.

Taking more Mysimba than is recommended can increase your risk of experiencing severe side effects, such as seizures.

Can I drink alcohol while taking Mysimba?

You should avoid or limit alcohol consumption while taking Mysimba.

Will Mysimba affect my ability to drive or operate machinery?

Mysimba may cause you to feel drowsy or dizzy. If you notice that this medicine has this effect on you, you should avoid driving or operating any machinery until you are well enough to do so.

Is Mysimba available on the NHS?

No, Mysimba is not available on the NHS. However, you can buy Mysimba online from Prescription Doctor.

Simply fill out our short medical questionnaire and our online doctor will determine whether the medicine is suitable for you.

Buy Mysimba online

You can buy Mysimba from Prescription Doctor's trusted online pharmacy.

Our online prescribers are on hand to issue a prescription for Mysimba, if deemed suitable by our doctor.

Table of contents

What is Mysimba?

How does Myimba work?

How to take Mysimba?

Side effects and cautions

Frequently asked questions

Buy Mysimba online

Treatment information

  • Product Name: Mysimba
  • Manufacturer: Orexigen Therapeutics
  • Active Ingredient(s): Naltrexone hydrochloride and bupropion hydrochloride
  • Administration: Oral
  • Presentation: Tablet
  • Available Strength: 8mg/90mg
  • Exemption: Prescription Only
  • Application: Adults with a BMI above 30
  • Dosage: Take as prescribed by the doctor
  • Alcohol Consumption: Avoid or limit alcohol consumption
  • When Pregnant: Do not take Mysimba during pregnancy. Speak to your doctor for further advice.
  • When Breastfeeding: Do not take Mysimba while breastfeeding. Speak to your doctor for further advice.
Click here to view the Mysimba - Patient Information Leaflet

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