Mysimba

About Mysimba Tablets 

Looking for a different way to manage your weight? MySimba is a prescription weight loss tablet that helps reduce cravings and emotional eating by working on your brain’s reward system. It’s ideal for those who struggle with food obsession or eating out of habit rather than hunger, as it helps you fight the urge to consume more calories than necessary.
Originally developed to treat addiction, Mysimba is licensed in the UK to support weight loss in adults with a high body mass index and/or weight-related health conditions. By helping to reset your brain’s response to food, MySimba makes it easier to stay on track with healthier habits.
You can buy Mysimba weight loss tablets from Prescription Doctor after an online consultation. If your order is approved before 3pm on a weekday, your treatment will be dispatched in discreet packaging via a next-day delivery service. 

Mysimba Cost and Pack Sizes 

Prescription Doctor is pleased to offer Mysimba weight loss tablets at the following prices: 

What is Mysimba?

Mysimba is a prescription-only medication that combines two active ingredients (8mg of naltrexone and 90mg of bupropion) that work together to reduce hunger, limit cravings and control emotional or compulsive eating. While not a quick fix, the treatment can be a valuable tool when used in conjunction with a healthy diet and regular exercise.

Naltrexone is used to treat alcohol or opioid dependence, while bupropion is used as an antidepressant and to help people quit smoking. When used together in Mysimba, these two compounds target specific areas in your brain to help rewire your eating habits, allowing you to have more control over food choices.

What Makes Mysimba Unique?

Mysimba stands out from other weight loss pills due to its dual active ingredients and its effect on the body. While the majority of its competitors focus on fat storage, Mysimba tablets work by suppressing appetite. This means you won’t need to eat as much to feel full and will experience hunger pangs less frequently.

For optimal results, Mysimba weight loss pills should be used in conjunction with a low-calorie diet and regular physical activity. 

How Do Mysimba Weight Loss Tablets Work?

Mysimba affects the part of the brain that controls hunger and food cravings. Here's how:  

• Naltrexone blocks the brain’s reward response to food. This means that when you eat foods that normally trigger a pleasure response, that effect is reduced, helping you break the cycle of reward eating. 
• Bupropion is an antidepressant that stimulates certain neurons involved in appetite control and dopamine release. This can help reduce the urge to snack or resist the temptation of sudden cravings.

Together, these ingredients help reset your brain’s relationship with food, making it easier to eat less and make healthier choices. This is particularly useful for people who eat due to factors such as emotions, stress, or habit, rather than hunger.

How Long Does Mysimba Take to Work?

Everyone responds differently to medicines, but you may start noticing changes within the first few weeks. You can expect reduced food obsession/snack cravings early on. Full weight loss benefits typically accumulate over 8 to 16 weeks, especially once you reach your maintenance dose.

Your progress should be assessed at the 16-week mark. If you’ve lost at least 5% of your starting weight by then, treatment may be continued. Should this benchmark not be achieved, our clinicians may recommend an alternative weight loss medication. Remember that Mysimba works best in conjunction with regular exercise and a healthy diet, so you must be committed to making lasting lifestyle changes to achieve the best results. 

How Long Does Mysimba Last?

Mysimba continues to support weight loss throughout your treatment, provided you adhere to the regular dosage schedule. When you stop taking the medication, naltrexone will fully leave the body in approximately 10 hours, while bupropion takes around 42 hours. At the start of your journey, you’ll get a pack of 112 Mysimba tablets, which will last approximately 5 weeks. 

Mysimba Results for Weight Loss

The key studies for Mysimba involved four major Phase 3 trials. Over 4,000 (4,536) participants with a body mass index (BMI) from 27 to 45 kg/m² were trialled. These trials were double-blinded, placebo-controlled studies. This reduces bias because neither the participants nor the researchers know who receives which drug (could either be Mysimba or a placebo).

Studies lasted between 28 and 56 weeks and included a structured lifestyle modification program that focused on reducing caloric intake and increasing physical activity. In one of these trials, participants taking Mysimba lost an average of 5.4% of their body weight compared to just 1.3% for those on placebo. In another study, which included an intensive behavioural modification programme, participants on Mysimba experienced an even greater average weight loss of 8.1% at the 56-week mark, while placebo participants lost only 4.9%.

The main findings from these trials showed that 31% of participants on Mysimba achieved at least a 5% weight loss compared to only 12% in the placebo group. Improvements were also observed in waist circumference and certain cardiovascular health markers, such as cholesterol.

Mysimba did, however, result in more side effects compared to the placebo. The most common of these were nausea, constipation and headaches. More participants on Mysimba discontinued treatment due to these effects, suggesting that a higher chance of side effects can affect patient adherence

Mysimba Eligibility Criteria

Mysimba may be suitable if:

You have a body mass index (BMI) of 30 or more, or 
A BMI of 27+ with a weight-related health condition such as high blood pressure, diabetes (Type 2) or high cholesterol

Other important criteria include:

• Be between 18 and 75 years old 
• Not be pregnant or breastfeeding 
• Not taking certain antidepressants or opioid painkillers

To make the most of your weight loss journey, it's recommended that you're ready to commit to lifestyle changes, such as a healthy diet and regular exercise. Our healthcare team at Prescription Doctor will go over all of this in a detailed online consultation before a prescription is approved.

How to Take Mysimba Tablets 

Take Mysimba tablets by mouth. Be sure to swallow the pills whole; never break or bite into them. While you can take the medication with or without food, doing so with a meal may help reduce side effects like nausea.

To get the most from Mysimba, it's essential to combine the tablets with a balanced diet. What does this involve? Whole foods, lean proteins, healthy fats and plenty of fruit and vegetables. This should be paired with regular physical activity such as walking, swimming or strength training.

Think of Mysimba as a support tool rather than a magic fix; it helps control your cravings so you can better stick to your food and exercise plans. Regular check-ins with your clinician can help track your progress and make adjustments if needed.

Mysimba Dose Regimen

Each Mysimba tablet contains 8 mg of naltrexone and 90 mg of bupropion. The full maintenance dose is 32 mg / 360 mg per day, divided across four tablets.

It’s important to build your dose up gradually over 4 weeks. An example dosing schedule would be: 

Starting at a lower dose helps your body adjust and reduces the risk of nausea or headaches. If you experience strong side effects during the dose increase, your prescriber may suggest staying at your current dose for a longer period before increasing it.

How Long Does a Pack of Mysimba Last?

Once you reach the full dose (4 tablets a day), a 112-tablet pack will last 28 days. In the first month, it may last a little longer, depending on your schedule. If you stop the medication or your dose is adjusted, speak to your clinician before restarting.

What If I Miss a Dose of Mysimba?

Skip the missed dose and continue as normal. Don’t double the dose to make up for it. Missing one dose occasionally won’t affect your long-term results. However, if you miss several days, you may need to restart at a lower dose to avoid side effects, as your body’s response to the medicine has changed. Discuss this with your clinician.

Mysimba Side Effects

Like all medicines, Mysimba can cause side effects. However, most of them will subside after a few weeks as your body gets used to the medication. Here are some Mysimba side effects that you may experience: 

The above is not an exhaustive list of Misimba side effects. Please refer to the Product Information Leaflet for further details. 

How to Manage Mysimba Side Effects

To manage mild side effects:

• Take tablets with food to reduce nausea 
• Drink plenty of water if your mouth is feeling dry
• Avoid caffeine if you feel jittery or anxious 
• Keep to a regular sleep schedule if you notice insomnia

If you experience serious side effects or your symptoms don’t ease after a few weeks or worsen, stop taking the medication and speak to your clinician.

Mysimba Interactions and Allergies

It is important to be aware of potential interactions between Mysimba and other medications. Informing the prescriber about all current medications, including those prescribed by a doctor and over-the-counter medications, is crucial to ensure safety and prevent potential adverse effects. It is advisable to consult your healthcare professional or refer to reputable sources for a comprehensive list of interactions. If you have a known allergy to naltrexone hydrochloride, bupropion hydrochloride, or any other ingredient in Mysimba, it is important to avoid taking this medication.

Bupropion: To view a comprehensive list, visit NICE interactions.

Naltrexone: To view a comprehensive list, visit NICE interactions.

How to Buy Mysimba Weight Loss Tablets

The easiest way to buy Mysimba is through an online weight loss service such as Prescription Doctor. Remember that your safety and privacy come first, so you should only trust a pharmacy that’s registered with the General Pharmaceutical Council (GPhC).

Can You Buy Mysimba Online?

Yes, it’s possible to buy Mysimba online with Prescription Doctor. As a licensed provider, we offer discreet delivery and full clinical oversight, ensuring you are in safe hands.

Here’s how our process works:

• Consultation: Provide information about your medical history, any existing health conditions and lifestyle factors which can influence treatment. Completed in-person or via online questionnaire.
• Assessment: Our prescribers review your answers to determine if Mysimba is right for you. 
• Decision: Depending on the outcome of the consultation, a prescription will be issued for the medication, or an alternative weight loss treatment may be more appropriate for you. 
• Delivery: If approved before 3pm on a weekday, your order should be delivered in secure packaging the next day. A full refund is issued in the event your order is cancelled for whatever reason. 
• Follow-up: Regular check-ups are scheduled once you have started Mysimba weight loss treatment to ensure everything is optimised.

Do I Need a Mysimba Prescription?

Yes, Mysimba is classified as a prescription-only medication, so it cannot be bought over the counter from pharmacies. This is because a licensed clinician is required to determine whether it’s suitable for your circumstances before issuing treatment, a process that is usually carried out via a consultation. 

Is Mysimba Available on the NHS?

No, Mysimba isn’t widely available on the NHS. Instead, you must obtain a prescription from private or online healthcare services, such as Prescription Doctor. You may also be able to access Mysimba tablets via some specialist weight loss clinics under certain criteria. 

Frequently Asked Questions About Mysimba Tablets