Xenical (Orlistat)

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  4. Our team of expert prescribers will assess whether medication is suitable.
  5. If you get the green light and it is deemed suitable, your order will be processed quickly and efficiently.
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Patient Reviews: How Xenical (Orlistat) Has Made a Difference

Treatment Information

Table of contents:

About Xenical Tablets  

Xenical capsules are a prescription treatment clinically proven to support weight loss and prevent weight gain when used in conjunction with a healthy lifestyle. The medication works locally in the gut without affecting your mood or brain chemistry, making it a popular long-term solution.

Available in capsule form, Xenical is the branded name for orlistat and contains 120 mg of the ingredient. When taken in conjunction with a healthy diet and regular exercise regimen, the medication has been proven to facilitate weight loss.

You can buy Xenical online from Prescription Doctor after a brief consultation to determine whether Xenical capsules are suitable for your circumstances. Provided your order is approved before 3pm Monday to Friday, we can dispatch your items via next-day delivery in plain packaging. 

 

Xenical Price & Pack Sizes 

Prescription Doctor offers Xenical tablets at the following prices: 

 

Number of Capsules 

Lasts For

Price

84

4 Weeks

£84.95

168

8 Weeks

£144.95

252

12 Weeks

£199.95

 

We also stock generic Orlistat tablets and the over-the-counter version of orlistat known as Alli

 

What is Xenical?

Xenical is a medication used to treat obesity. Unlike some popular products that affect your mood or hunger sensations, Xenical 120 mg capsules work by blocking the digestion of certain dietary fats, allowing them to pass through your body instead.

Because Xenical is a branded form of orlistat, it may also be referred to by its active ingredient name in medical settings. Both are equally effective at blocking fat absorption; the main difference is the manufacturer and the name on the box. You can buy orlistat both as Xenical and a generic medication, and also as an over-the-counter treatment known as Alli

 

How Does Xenical Work for Weight Loss?

Xenical weight loss capsules work by blocking an enzyme called lipase, which is necessary for breaking down dietary fat into molecules that can be absorbed by the body. When active, the medication prevents around 30% of the fat you eat from being digested. This results in fewer calories being absorbed per meal, without needing drastic cuts in the volume of food you eat.

Unlike alternative weight loss treatments such as Mounjaro and Wegovy, which mimic naturally occurring hormones in the brain, Xenical only targets the digestive system, earning it the classification of a ‘peripherally acting anti-obesity agent’.

Xenical tablets only work if you have eaten a meal that contains fat. If your food has no fat content or you skip a meal completely, there’s no need to take a capsule as it will have no effect. 

How Long Does Xenical Take to Work?

When taking Xenical weight loss capsules alongside a reduced-fat, calorie-controlled diet, you may notice subtle changes within the first few weeks of treatment. More significant results tend to build over 8 to 12 weeks when taken consistently with each meal containing fat.

Some promising signs to indicate that the medication is working include feeling lighter, less bloated, or having slightly looser clothing. These can occur early on in treatment, giving you the confidence you need to progress with your journey. Remember, though, products like Xenical are not designed to be fast-acting solutions. Instead, they generate sustained, long-lasting results.

How Long Does Xenical Last?

Because Xenical capsules are designed to only last for one meal, you will need to take one every time you have a meal that contains fat. You can take up to a maximum of 3 tablets each day. Xenical will continue working for as long as you take it. The medication has a half-life of around 1-2 hours

 

Xenical Weight Loss Results

Xenical’s effectiveness for weight loss has been extensively studied. A four-year trial found that nearly half (41%) of Xenical users lost 10% or more of their starting body weight within one year of taking the medication, compared to just 21% of those using a placebo. In the same trial, 60% of participants experienced a drop of 5% or more within 12 weeks alone.

Meanwhile, pooled results from several two-year studies revealed that the average difference in weight loss between people taking Xenical capsules and those without was approximately 3.2 kg in the first 12 months of treatment. The majority of trials were randomised, double-blind, placebo-controlled experiments, meaning neither the participants nor the researchers knew who received Xenical and who received a placebo. This is known as the ‘gold standard’ in clinical research.

An additional benefit of Xenical was observed in individuals with impaired glucose tolerance, a condition that precedes diabetes. Those using the medication were 2% less likely (3.4% vs 5.4%) to develop type 2 diabetes over a four-year period than individuals taking a placebo.

How Much Weight Can You Lose on Xenical in a Month?

Clinical trials have shown that consistent use of Xenical 120 mg capsules, combined with a healthy, lower-fat diet and regular exercise, can help you lose approximately 1-2 kg in the first month, although results may vary from person to person.

Over 3 to 6 months, most people can expect to lose 5-10% of their starting weight, with progress reviewed at 3 months to assess whether the treatment is working effectively for you. A weight drop of at least 5% after 12 weeks means that the medication is suitable.
 

Xenical Prescription Criteria

To be eligible for Xenical, you must:

  • Be over 18 years old 
  • Have a BMI of 30 or more, or 28+ with conditions such as high blood pressure or type 2 diabetes 
  • Not be pregnant or breastfeeding 
  • Not have chronic malabsorption issues or gallbladder problems

 

How to Take Xenical for Best Results

Xenical comes in 120 mg capsules to be taken with meals. Ensure you swallow the capsule whole, without breaking it. For optimal weight loss results, take them with meals that contain a small to moderate amount of fat, such as lean proteins or healthy oils. Avoid using them when eating a fat-free meal, as this can cause uncomfortable side effects.

It’s essential that your diet is nutritionally balanced, with approximately 30% of calories coming from fat, which should ideally be distributed evenly across three meals. Aim to reduce your intake of high-fat foods, such as fried items, full-fat dairy, and fatty cuts of meat. Xenical capsules should be taken in conjunction with a low-calorie diet and regular exercise. Consistently, evidence shows that combining weight-loss medication with healthy eating and exercise leads to greater weight loss than using either approach alone. 

 

Xenical Dosage Information

The standard dose for Xenical is one 120 mg capsule, taken up to three times per day. Ideally, this is done just before, during, or within one hour after a main meal that contains fat. Most people take Xenical capsules initially for 12 weeks. If you’ve lost at least 5% of your body weight at this point, treatment can continue. 

What if I Miss a Dose of Xenical?

If you miss a dose of Xenical and it has been less than an hour since you had a meal that contained fat, take one capsule as soon as you remember. If it has been more than one hour, skip the missed dose and wait until your next meal to take a tablet as usual. Do not double-dose Xenical. 

How Long Should I Take Xenical For?

For many, Xenical becomes part of a longer-term weight management strategy. It is considered safe for up to 1 year of use, although this timeframe can be extended further, provided you continue to see benefits and don’t experience side effects. Regular check-ins with your prescriber can help you track progress and ensure the medication is supporting your weight loss goals.

 

Xenical Side Effects

Xenical is generally well-tolerated; however, it can cause side effects, particularly when consumed in excessive amounts of fat. Here are some Xenical side effects that you might experience:

 

Common

(affects 1 in 100 to 1 in 10 people)

Uncommon

(affects 1 in 1000 to 1 in 100 people) 

Serious

(seek immediate help)

Oily or fatty stools 
Frequent bowel movements 
Excess wind 
Stomach pain/cramping
Headaches 
Tiredness
Anxiety 
Sleep issues
Severe stomach pain 
Signs of liver issues (e.g. dark urine, yellowing skin)
 

 

It’s important to note that the above is not an exhaustive list of potential Xenical side effects. For a more thorough understanding, please refer to the Patient Information Leaflet included with the medication.  

How to Manage Xenical Side Effects

Most Xenical side effects settle once your body adjusts, or if you reduce your fat intake. Common issues, such as oily stools and excess gas, tend to subside after a few days or weeks, especially if you adhere to a lower-fat diet. Eating smaller, leaner meals can also help.

To minimise side effects, try spreading your fat intake evenly across meals and avoiding greasy or fried foods. Drinking plenty of water, eating more fibre, and choosing lean protein sources can also help regulate digestion.

If these symptoms persist or you experience more severe symptoms, consult your clinician.

 

Where to Buy Xenical Weight Loss Pills

You can buy Xenical from trusted online providers, such as Prescription Doctor, or through brick-and-mortar pharmacies. Many people choose the online route because there’s no waiting to book appointments, as the necessary consultation process can be completed from the comfort of your own home via a medical health questionnaire. 

Can I Buy Xenical Online?

Yes, it’s possible to buy Xenical online with Prescription Doctor. As a licensed provider, we offer discreet delivery and full clinical oversight, ensuring you’re in safe hands.

Here is how our process works:

  • Consultation: Fill in our online medical questionnaire and our clinicians will review your information to determine if Xenical is suitable for your circumstances
  • Decision: If approved, your medication will be dispatched in plain and discreet packaging, potentially for next-day delivery
  • Follow-Up: Our clinicians will regularly check in with you to monitor progress and ensure that your Xenical weight loss treatment remains the best option for you

Remember that if you do buy Xenical online, be sure to check that the pharmacy is registered with the General Pharmaceutical Council, so you can be confident about quality. 

Can I Buy Xenical Over-the-Counter?

No, because Xenical is classified as a prescription-only medication (POM), it is not possible to buy it over the counter. Instead, you must obtain approval from a licensed medical professional to ensure the treatment is suitable for you and your specific circumstances.

Xenical’s active ingredient, orlistat, is available over-the-counter in the form of Alli. This medication comes in 60 mg capsules and is a popular weight loss treatment in its own right.

Is Xenical Available on the NHS?

Yes, Xenical is available on the NHS, but access is limited. You’ll usually need a BMI of over 30 and a referral to a weight management service. Many people choose to buy Xenical privately through online services such as Prescription Doctor for faster access.

 

Frequently Asked Questions About Xenical Weight Loss

Is Xenical the Same as Orlistat?

Xenical and Orlistat are considered to be the same medication. Both support weight loss by blocking fat absorption in the gut. The only real differences between the two are branding and dosages. While Xenical is exclusively available in 120 mg capsules, orlistat can be bought in 120 mg and 60 mg versions (Alli).

Both Xenical and generic Orlistat capsules are equally effective in achieving weight loss results. However, some patients may prefer Xenical for its reputation and consistency. 

How to Store Xenical Tablets

Keep Xenical capsules in their original packaging and store them at room temperature, ideally below 25°C. Ensure they’re kept away from moisture and direct sunlight, and stored out of reach of children and animals. Do not use the capsules past their expiry date.

Who Shouldn’t Take Xenical 120 mg Tablets?

Avoid Xenical if you:

  • Have gallbladder issues or chronic malabsorption syndrome 
  • Are allergic to any ingredients in the capsule 
  • Are under 18 years old 
  • Have a diagnosed eating disorder 
  • Taking certain medications such as ciclosporin

Always consult a clinician before starting or switching treatments.

How Does Xenical Interact with Other Medications?

Just like all medications, Xenical can interact with other treatments, making them less effective. You should especially inform your doctor if you are taking medications such as:

  • Epilepsy treatments
  • Amiodarone, a heart medication
  • Ciclosporin for rheumatoid arthritis
  • HIV treatment
  • Warfarin and other anticoagulant drugs
  • Levothyroxine and/or iodine salts
  • Acarbose, a diabetes treatment
  • Medication for mental health disorders

When completing a medical consultation, it is essential to detail all types of treatment you are currently taking, including over-the-counter medications and herbal remedies. 

Can I Switch to Xenical from Other Weight Loss Treatments?

Yes, switching to Xenical is a common practice. If you’ve tried other weight loss treatments like Wegovy, Mounjaro, or Nevolat (liraglutide) and found them unsuitable, Xenical offers a non-injectable, cost-effective alternative. Likewise, you can also switch from Xenical to other treatments, such as Xenical or Mysimba, if you prefer a different approach.

The decision to switch should be discussed with your clinician as each treatment has a different ‘half-life, meaning the time it takes for the existing medication to clear from your body can differ.

Can You Drink Alcohol with Xenical?

Yes, you can drink alcohol while taking Xenical capsules, but it’s essential to do so in moderation. While alcohol itself doesn’t interact with the medication, it is high in calories and can easily undo your progress if consumed in excess.

Can I Take Xenical with Supplements?

While you can generally take Xenical with supplements, the medication may affect the effectiveness of supplements containing fat-soluble nutrients, such as beta-carotene and Vitamin E. This is because Xenical reduces the amount of fat absorbed from food. If you do use supplements like these, you may want to obtain these nutrients through your diet instead.

What are the Alternatives to Xenical?

There are several weight loss treatments available, both in tablet and injection form. At Prescription Doctor, we offer the following alternatives to Xenical:

  • Mounjaro: A dual-action, once-weekly injection containing the active ingredient tirzepatide
  • Wegovy: A subcutaneous injection with the active ingredient semaglutide. Also taken once per week
  • Nevolat: The generic form of Saxenda, this injection is administered once per day
  • Mysimba: Weight loss tablets that reduce cravings and emotional eating
  • Alli: An over-the-counter version of orlistat, available in 60 mg capsules 
  • Orlistat: The generic form of Xenical, taken in capsule form

 

 

 

Treatment information

  • Name: Xenical
  • Active Ingredients: Orlistat
  • Manufacturer: Cheplapharm Arzneimittel GmbH
  • Administration: Oral
  • Presentation: Capsules
  • Available Strength: 120 mg
  • Exemption: Prescription-only medicine
  • Application: Men and women over 18
  • Dosage: One capsule with water immediately before, during or up to one hour after each main meal.
  • Description: Weight loss in conjunction with a mild hypo-caloric diet.
  • Drug Class: Lipase inhibitor
  • Alcohol Consumption: Do not drink alcohol
  • When Pregnant: Do not consume. Speak to your doctor for further advice.
  • When Breastfeeding: Do not consume. Speak to your doctor for further advice.
  • Price: 21.99 GBPhttps://www.prescriptiondoctor.com/storage/product_images_th/lh0MljhfDVlbXN22Si8B2xSnOPKKJX.jpg
Click here to view the Xenical (Orlistat) - Patient Information Leaflet

Authored By

Cong

Cong Cao

Medical Content Writer
Cong is a UK-registered pharmacist and a graduate of The University of Manchester, with diverse experience across hospital, community and industry pharmacy settings. He has a strong background in crea

Published on: 18/01/2017 Re-Published on: 05/09/2025

Reviewed By

Mohamed Imran Lakhi

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Reviewed on: 05/09/2025

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