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How To Take Mysimba?

If you want to try Mysimba for weight loss, or you’ve been prescribed it and want more information on how to take MySimba, you’re in the right place.

Mysimba is a tablet taken daily to treat obesity. Your dose of Mysimba will be slowly increased over 4 weeks. Knowing how and when to take Mysimba safely will reduce the risk of side effects and increase its effectiveness.

Forms and Dosage

Mysimba comes in the form of a tablet, containing 8 mg of naltrexone hydrochloride and 90 mg of bupropion hydrochloride. The typical daily dosage is 4 tablets.

Mysimba Dosage Titration

Your Mysimba dosage should be gradually increased over 4 weeks. This reduces the risk of common side effects whilst your body adjusts to the medication.

How Many Tablets Should I Take Per Day?

You should take Mysimba every day, as follows:

Week 11 tablet, in the morning
Week 22 tablets, 1 in the morning and 1 in the evening
Week 33 tablets, 2 in the morning and 1 in the evening
Week 4 onwards4 tablets, 2 in the morning and 2 in the evening

When Should You Increase the Dose?

You should increase the dose every week, counting from the day you start. For example, if you start taking Mysimba on a Monday, the next dose increase would be the following Monday.

Dosage Considerations

When Is the Best Time to Take Mysimba?

MySimba should preferably be taken with food, as this reduces the chance of nausea and vomiting. It should be taken in the morning and evening, so you might want to take it with your first and last meal.

It doesn’t matter if you take it before, during, or after eating.

Can You Take Mysimba at Night?

You can take Mysimba at any time in the evening or night, but preferably with food. Try to stick to around the same time each day.

How Often Should Mysimba Be Taken?

This depends on whether you are still on the titration dose or the standard dose. Once you reach the maximum dose, you should take it twice a day, every day.

What Should I Do If I Miss a Dose?

If you miss your Mysimba dose, skip it and carry on as normal when your next dose is due.

Never take a double dose, as this could cause serious side effects.

What Should I Do If I’ve Taken More Than I Should?

If you’ve taken more Mysimba than you should, it could increase your chance of having serious side effects, such as a fit. Go to A&E or speak to a doctor immediately and take your medication packet with you.

Considerations and Precautions for Special Groups

Mysimba is not suitable if you are:

  • pregnant
  • breastfeeding
  • under 18 or over 75

If you’ve got any pre-existing medical conditions, such as depression, speak to your doctor as Mysimba may not be suitable.


You should not take Mysimba if you’re taking another medication containing bupropion or naltrexone. For any other medication or herbal supplement, speak to your doctor.

Can You Take Mysimba on an Empty Stomach?

You can take Mysimba on an empty stomach but it’s not recommended.


The standard Mysimba dosage is 2 tablets twice a day, in the morning and evening, with food. It’s best to stick to around the same time each day. Your dosage will be increased over 4 weeks, to get your body used to the medication with minimal side effects.

If you want to lose weight, speak to a healthcare professional about taking medication alongside an exercise and diet plan. You can also speak to one of our prescribers, learn more about Mysimba, or check out other weight loss treatment options.

Authored & Reviewed By

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 03/10/2023 Reviewed on: 01/11/2023
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