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How Long Does Spedra Take To Work?

This article looks at Spedra efficacy, timing, duration, long-term use, plus factors that could affect how it works. So, keep reading to find out the answer to how quickly can Spedra help treat erectile dysfunction?

Speed of Action

Spedra tablets are a type of phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction (ED).

Spedra works in as little as 15 to 30 minutes.

Spedra absorption time is between 30 to 45 minutes. It’s recommended to take it around 30 minutes before sex.

Spedra needs time to absorb, it won’t work immediately.

Treatment Duration

Spedra doesn’t follow a set treatment regime, as you only need to take it when you plan to have sex.

Spedra half-life is 6 to 17 hours. Spedra remains effective for around 4 to 6 hours.

Only use Spedra if you’ve been diagnosed with ED. It’s unsafe to take Spedra if you are:

  • under 18
  • a woman, especially if you’re pregnant or breastfeeding

Long-term Use

You can use Spedra (avanafil) for as long as you need it, but if you get serious or bothersome side effects you may have to lower your dose or stop treatment.

Spedra can only be taken once a day. You should have regular medical check-ups about your dosage and the long-term use of Spedra.

Risks and benefits of long-term use

The risks of using Spedra long-term include:

  • chance of side effects, such as headache, flushing, dizziness, or blurry vision
  • painful, prolonged erections
  • insomnia
  • weight gain

The benefits of using Spedra long-term include:

  • being able to have sex and not worry about getting an erection
  • improved sexual confidence
  • quick onset
  • doesn’t need to be taken daily

Dosage and Factors Affecting Efficacy

Spedra works best if:

  • you avoid large meals before taking it
  • you’re sexually stimulated
  • you avoid drinking alcohol before using it, as this could make you feel lightheaded and dizzy

Spedra comes in 3 doses: 50 mg, 100 mg, and 200 mg. If you take certain medications, you may not be able to take the highest dose, or you’ll have to leave at least 2 days between doses.

What to Do If You Find the Dose Ineffective

If you find your current dose of Spedra ineffective after trying it 8 times, speak to your doctor. They may increase your dose or recommend a different treatment.


Spedra takes about 30 minutes to work and lasts 4 to 6 hours. It works best if you’re sexually stimulated. Speak to your doctor if you need additional information about the long-term use of Spedra.

We also have a range of ED treatments available, as well as additional resources and support if you’re taking or want to take Spedra.

Authored By

Hannah Aitken

Medical Content Writer
Hannah is a medical content writer who utilises her nursing expertise alongside her passion for writing healthcare content.

Published on: 06/11/2023

Reviewed By

Dr. Giuseppe utilises his extensive experience in general practice to ensure the accuracy and safety of the website's content.

Reviewed on: 16/11/2023
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