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How Long Does Kliofem Take To Work?

If you have been prescribed Kliofem to relieve the debilitating symptoms of menopause, you’re probably looking to learn more about this hormone replacement therapy (HRT) method, particularly how quickly it’ll start working.

Here, we’ll help you understand when you’ll start noticing the benefits of Kliofem and how long you’ll need to use it.

How long does Kliofem take to work?

Kliofem is an effective, daily HRT tablet and usually starts working in 10 days. It is used to relieve menopause symptoms, like hot flushes and can prevent osteoporosis if you are at high risk of bone fractures. Some people may find that it can take a little longer for Kliofem to work or to notice a difference in their symptoms. How quickly Kliofem will work for you will depend on how your body reacts to the treatment.

The NHS states that it can take up to 3 months for continuous combined HRT to improve your symptoms completely. That’s why it is important to continue with your treatment and to take your pills every day as prescribed by a clinician. This will help to make sure Kliofem works as effectively as possible.

Does Kliofem provide immediate relief?

No, Kliofem isn’t designed to give immediate relief from menopause symptoms. It can take up to 3 months for Kliofem to be fully effective. However, it’s common for some women to start feeling different within a few days or weeks.

Will I experience side effects when I first start Kliofem?

When you first start Kliofem, you may experience some side effects as your body adjusts to the new hormone levels. Usually, these are mild and should go away once your body gets used to Kliofem. The most common side effects in the first 3 to 6 months of Kliofem treatment are irregular bleeding or spotting.

How long does Kliofem remain active in the body?

Kliofem has a half-life of around 18 hours which is how long it is active in the body. That’s why you should take your dose as prescribed to ensure its continued effectiveness.

How long can I take Kliofem for?

How long you’ll need to take Kliofem will depend on your circumstances. However, if it is an effective method of HRT for you, then you may take it until the symptoms of menopause pass. It is common for women to take combined HRT, like Kliofem, for 2 to 5 years.

Menopause symptoms typically last 4 years after a woman’s last period, although this can vary. Some women can experience hot flashes for as long as 10 years.

Kliofem is suitable for women who have not had a period for at least 12 months.

Risks and benefits of taking Kliofem long term

Continuous, combined HRT can increase the risk of breast and womb cancerLong-term relief from menopause symptoms, such as hot flushes, mood swings and vaginal dryness
Kliofem may increase the risk of blood clots in the veins, legs, or lungs, heart disease and strokesProtects against osteoporosis
You may experience withdrawal effects when you stop taking Kliofem 

What if Kliofem isn’t working?

If you feel that Kliofem isn’t relieving menopause-related symptoms, you should speak to a clinician to discuss your options.

Before changing medicines or doses, it is worth considering the following:

  • How long have you been taking Kliofem? It can take up to 3 months to feel the full benefit of continuous combined HRT.
  • Are you taking Kliofem as it was prescribed? If you frequently miss doses or are not taking Kliofem as prescribed, it may be less effective.
  • Is the Kliofem dose in date? Check the box and the date printed on the pill strip to ensure it has not passed the expiry date.
  • Are you storing Kliofem properly? Kliofem should not be stored in the fridge. You should also keep the pill strip inside the box when not in use to protect the pills from light.
  • Are you taking any medicines that could affect Kliofem’s effectiveness? Let your clinician know if you take any prescribed, over-the-counter, or herbal medicines. That’s because some drugs can interfere with how Kliofem works.

If none of the above applies to you and you do not feel any difference in your symptoms after 3 months, you should discuss alternative menopause treatments with a clinician.


Kliofem is an effective continuous combined HRT that can start working to relieve menopause symptoms in as little as 10 days. But it can take up to 3 months to feel the full benefit of HRT, including Kliofem, but it is safe to take long-term to help relieve the uncomfortable symptoms of menopause, such as hot flushes and vaginal dryness.

Authored By

Leanne Edermaniger

Medical Content Writer
Leanne is a science and health content writer focusing on human health and biology while utilising her solid academic background.

Published on: 29/09/2023

Reviewed By

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Reviewed on: 01/11/2023
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