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You must complete a short online consultation so that our prescriber can ensure that the treatment is suitable for you.
Order now to receive your order Friday, May 24
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How to order
  1. Click on the green "Back To Get Started" button, then click "Start Consultation" button on the next page.
  2. Fill in our short consultation form.
  3. Choose delivery method and mode of payment.
  4. Our team of expert prescribers will assess whether medication is suitable.
  5. If you get the green light and it is deemed suitable, your order will be processed quickly and efficiently.
Confidential Service

Your privacy is important, Prescription Doctor are committed to keeping your details completely confidential.

This is why we also take steps to conceal your prescription products under two layers of packaging.

Delivery and Packing
Discreet Delivery?

We have a commitment to delivering a discreet service and understand your need for privacy. We ship all orders via a trackable courier using discreet, plain packaging.

Do I Need to Wait in All Day for Delivery?

Once your order is dispatched you will receive a tracking number via sms and email.

Do You Deliver on Weekends?

We deliver medications between Monday and Saturday. You can upgrade to Saturday delivery on Friday.

My Order Hasn’t Arrived What Should I Do?

You should receive a tracking number with your order which you can use this number to track your parcel online. This should give you a clear indication of where your parcel is. If you haven’t received your parcel in the time frame given by our couriers, contact your local depot to find out where it is. You can also contact our support team who will do this for you.

Can I Be Notified by Text?

On checkout you will be asked to leave your mobile number so our courier can text you about the delivery. This is also useful if the courier has problems finding your address. We will not use your mobile number for anything else.

Payment Methods
How Can I Pay for My Order?

You can pay for your order using credit, debit card or via bank transfer.

I Don’t Have a Credit Card, How Can I Pay?

If you don’t have a credit or debit card you can pay via bank transfer. We will give you a unique reference number at checkout along with details of how to make the transfer. Once the money has cleared in our account, we will process your order.

How Do You Keep My Details Safe?

We are a completely secure site and take many measures to ensure your details are kept safe. We understand that you have a right to extreme privacy when purchasing sensitive health medications. All information that you provide to us is stored on our secure servers. Any payment transactions will be encrypted using SSL technology.

Payment and refunds?

You can pay for your order using credit, debit card and bank transfer.

Card Payment: Please notify us that you wish to cancel your order. Your refund will show available In 1 - 3 days.

Bank Transfer: A member of our team will contact you requesting for your bank details. These details are only used to transfer the funds back into your account.

Treatment Information

Table of contents

Patient Reviews: How Kliofem Has Made a Difference

What is Kliofem?

Kliofem is a continuous, combined hormone replacement therapy treatment (HRT) for postmenopausal women. It contains two synthetic hormones called estradiol and norethisterone, which are similar to the natural sex hormone oestrogen and progesterone, respectively.

Together, the synthetic hormones counteract the symptoms of the menopause.

The estradiol supplements the falling levels of the hormone oestrogen, while the norethisterone counteracts the effect of the estradiol, preventing the endometrium from growing excessively.

What is the menopause?

The menopause is the time in a woman’s life when her body stops preparing itself for pregnancy. Menstruation cycles and ovulation, which both slow down before stopping completely.

During the menopause, oestrogen levels in the body fall, which cause a number of symptoms such as:

  • Difficulty sleeping
  • Hot flushes
  • Lower sex drive (libido)
  • Mood swings
  • Night Sweats
  • Vaginal dryness

Typically, these symptoms begin between the ages of 45 and 55, with many women experiencing symptoms around the age of 51, according to the NHS.

If a woman particularly suffers from these symptoms, HRT can be prescribed to balance the hormones in the body.

How to take Kliofem?

Always follow the dosage prescribed by a healthcare professional.

Kliofem should be taken once daily at the same time each day.

Kliofem can be taken with or without food.

Swallow the tablets whole with a glass of water.

Do not crush or chew Kliofem tablets.

What should I do if I forget to take Kliofem when I should?

If you miss a dose, take it as soon as you remember.

If you miss a dose, and it has been 12 hours since your last dose, or if it is nearly time for your next dose, skip the missed tablet and take the next tablet as normal.

Do not take more than the prescribed dose of Kliofem. If you accidentally take more Kliofem than prescribed, seek immediate medical attention.

Side effects and cautions of Kliofem

Before you take Kliofem, you must read the enclosed patient information leaflet.

You can view the patient information leaflet for Kliofem online.

If you have any concerns or questions regarding any of the information detailed within the patient information leaflet, speak to your doctor or ask a pharmacist.

Who should not use Kliofem?

Kliofem should not be used by women who:

  • Had a disease caused by a blood clot in the past such as a heart attack, stroke or angina
  • Have a blood clotting disorder
  • Have a rare blood condition called porphyria (inherited)
  • Have any unexplained vaginal bleeding
  • Have excessive thickness of the endometrium (endometrial hyperplasia)
  • Have or had any blood clots in the veins (deep vein thrombosis or pulmonary embolism)
  • Have or had liver disease
  • Have, had or suspect they have breast cancer
  • Have, had, or suspected cancer of the womb lining (endometrial cancer)

Side effects

All medications carry the risk of side effects, though not everyone experiences them. Before taking your medication, it is important to familiarise yourself with the possible risks associated with your treatment by reading the patient information leaflet. This document can be found enclosed in your treatment.

Possible side effects of Kliofem may include:

  • Breast pain or tenderness
  • Changes in sex drive (libido)
  • Dizziness
  • Fluid retention
  • Gallbladder disease
  • Headaches or migraine
  • Increased risk of blood clots
  • Indigestion
  • Inflammation of the pancreas (pancreatitis)
  • Menstrual bleeding or spotting
  • Mood swings
  • Nausea
  • Tiredness
  • Vaginal thrush
  • Weight changes

This is not a complete list of side effects associated with Kliofem. Further information regarding the safety of Kliofem can be found in the patient information leaflet.

If you experience any side effects after taking Kliofem - regardless of whether they are listed above or in the patient information leaflet - report them to your doctor.


Do not take Kliofem if you are allergic to any of the ingredients.

Kliofem contains lactose. Speak to your doctor before taking Kliofem if you are sensitive to some sugars.

If you experience an allergic reaction to Kliofem, stop taking it and seek medical attention immediately. Go straight to your nearest A&E department. Remember to take the packaging and any remaining tablets with you, so that doctors treating you know exactly what you have taken.

Pregnancy and breastfeeding

Kliofem should not be used by women who are pregnant or breastfeeding. If you discover you are pregnant while taking Kliofem, stop treatment immediately and consult a doctor.

Kliofem is not a form of contraception. If it has been less than 12 months since your last period, or you are under the age of 50, you may need to use additional contraception - such as condoms - to prevent pregnancy.

Other safety information

Always read the patient information leaflet before you start taking Kliofem.

Use our online medical form to list all the medication you are taking, including those prescribed by your doctor, or bought over the counter. This is important information for our online prescribers.

Do not take Kliofem past the expiry date printed on the packaging.

Never dispose of medicines via household or water waste, as this can damage the environment. Instead, take any unwanted or expired medication to your local pharmacy and ask them to dispose them safely for you.

Always store Kliofem out of sight and reach from children and pets.

Never share your tablets with anybody else - even if they are experiencing the same symptoms or have been diagnosed with the same condition as you.

Staying safe with Prescription Doctor

In order for our doctors to issue a prescription, you will need to fill out a short medical form so that our prescribers can determine whether the treatment you requested is right for you.

If the doctor approves your order, a prescription will be issued and sent to our dispensing pharmacy, who will process your order.

If your order is processed before 3 pm, it will be dispatched in discreet packaging for next-day tracked delivery.

Treatment information

  • Product Name: Kliofem
  • Manufacturer: Novo Nordisk
  • Active Ingredient(s): Estradiol and Norethisterone
  • Administration: Oral
  • Presentation: Tablets
  • Available Strength: 2 mg Estradiol, 1 mg Norethisterone
  • Exemption: Prescription Only
  • Application: Postmenopausal women
  • Dosage: Take one tablet daily
  • Description: Kliofem is a continuous combined HRT for postmenopausal women
  • Drug Class: Hormones replacement therapy (HRT)
  • Alcohol Consumption: No influence
  • When Pregnant: Do not take Kliofem
  • When Breastfeeding: Do not take Kliofem
  • Price: 39.99 GBP
Click here to view the Kliofem - Patient Information Leaflet

Authored & Reviewed By

Mohamed Imran Lakhi

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 28/02/2019 Reviewed on: 13/03/2024

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