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Sandrena

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Sandrena Gel 0.5mg estradiol x28 sachets
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Treatment Information

Table of contents:

What is Sandrena Gel?

Sandrena Gel is a topical Hormone Replacement Therapy (HRT) designed to treat menopause symptoms by replenishing declining oestrogen levels.

It replaces the levels of oestrogen that decrease during menopause.

Available in two strengths: 0.5mg and 1.0mg of estradiol. Each pack contains 28 sachets.

Understanding Menopause Before Treating With Sandrena Gel

Understanding menopause is crucial before starting any treatment. It is a natural phase that marks the end of fertility and menstruation, typically occurring between the ages of 40 and 50.

Menopause is an inevitable phase for women, signalling the end of menstruation and fertility.

Premature menopause can occur due to surgical removal of the womb (hysterectomy) or ovarian failure.

In the UK, menopause symptoms last for an average of 4 years, but can range between 2 and 10 years.

Symptoms and Causes:

  • A decline in the female sex hormone oestrogen causes menopausal symptoms.
  • Common Symptoms Include:
  • Decreased muscle mass
  • Flushing
  • Headaches
  • Recurrent UTIs
  • Vaginal dryness
  • And more...

Sandrena Gel Treatment Options:

Sandrena Gel replenishes the body with estradiol, a form of oestrogen. Consult your doctor for appropriate treatment options, including HRT.

  • Sandrena Gel replenishes the body with an oestrogen called estradiol.
  • There are tests, such as the SELF Check Menopause Test, to confirm menopause.
  • Your doctor can discuss Hormone Replacement Therapies (HRT) to treat symptoms.
  • A doctor may also prescribe a progestogen alongside an oestrogen to reduce risks like endometrial hyperplasia or endometrial cancer.

How Do I Use Sandrena Gel?

Sandrena Gel is applied directly to the skin of the lower body, such as the thighs.

The active ingredient, estradiol, is absorbed through the skin.

Apply the gel to alternating sides of your body.

Rub the gel into your skin, ensuring it is spread evenly, and allow the area to dry.

Always wash your hands after applying the gel.

Sandrena Gel Side Effects and Cautions

Before using Sandrena gel, you must carefully read the patient information leaflet. This leaflet provides instructions on how to store and use the gel, as well as important safety information regarding Sandrena gel.

If you have any questions or concerns about any of the information presented in the patient information leaflet, feel free to discuss them with our online prescriber by using the “my chats” feature under your Prescription Doctor account.

Who should not use Sandrena Gel?

Sandrena is not suitable for everyone. If you are not sure whether Sandrena is suitable for you, consult your doctor.

Do not use Sandrena if you:

  • have or have ever had breast cancer
  • have cancer that is sensitive to oestrogens, such as endometrial cancer (cancer of the womb)
  • have any unexplained vaginal bleeding
  • have untreated endometrial hyperplasia
  • have or have ever had a blood clot in a vein (thrombosis)
  • have a blood clotting disorder
  • have or recently have had a disease relating to blood clots in the arteries (e.g. heart attack, stroke or angina)
  • have or have ever had liver disease or abnormal liver function test results that have not returned to normal
  • have a rare blood disorder called porphyria
  • are allergic to estradiol or any of the other ingredients listed in the patient information leaflet

If you notice any of the above conditions occur while taking Sandrena, stop using it and consult your doctor immediately.

Side Effects

All medicines carry the risk of side effects, although not everyone experiences them.

It’s essential to familiarise yourself with the side effects listed in the patient information leaflet and to remain vigilant for any potential side effects.

Common side effects may include:

  • bleeding or spotting
  • breast pain or tenderness
  • changes in mood (including depression, nervousness or lethargy)
  • changes in weight
  • dizziness
  • flatulence
  • headache
  • hot flushes
  • itching of the skin, rash, pain, increased sweating, swollen feet and lower legs
  • nausea
  • stomach ache
  • vomiting

This is not a full list of side effects associated with Sandrena gel. A complete list of side effects can be found within the provided patient information leaflet enclosed with the medicine.

If you experience any side effects, regardless of whether they are listed above or in the patient information leaflet, please inform your doctor as soon as possible.

Sandrena Gel Allergies

Do not use Sandrena if you are allergic to estradiol or any of the other ingredients listed in the patient information leaflet.

If you experience an allergic reaction after using Sandrena gel:

  • Stop using the product
  • Speak to your doctor

In the case of severe allergic reaction, such as anaphylaxis, go straight to your nearest accident and emergency department. Remember to take the packaging and any remaining sachets with you so that doctors treating you know exactly what you took.

Sandrena Gel During Pregnancy and Breastfeeding

Do not use Sandrena if you are pregnant or breastfeeding.

If you become pregnant while using Sandrena, stop using the gel immediately and consult your doctor.

Sandrena is not a contraceptive. If fewer than 12 months have elapsed since your last period, or you are under 50 years old, you may still become pregnant. You may still need to use contraception such as condoms to prevent pregnancy.

Other safety information

Inform our online prescriber of all other medicines you are currently using, including medicines prescribed by your doctor, or bought over the counter, as well as any health and herbal supplements you are taking.

Never use Sandrena Gel past the expiry date printed on the packaging.

Always store Sandrena gel out of sight and out of reach of children and pets.

Store Sandrena gel sachets in the original packaging. They should be stored at room temperature.

Do not store Sandrena above 25°C.

Never throw away medicine via household or water waste. Take any unwanted or expired medicine to your local pharmacy and ask them to dispose of it safely on your behalf. These measures can help to protect the environment.

Where Can I Buy Sandrena Gel Sachets Online?

At Prescription Doctor, we make the process of obtaining Sandrena Gel Sachets straightforward and secure. You can place an order online from a GPhC-registered pharmacy, ensuring that you're receiving a genuine and quality-assured product.

If you complete your order before 3pm on a weekday, our dedicated pharmacy team will dispatch it the same day, offering you the convenience of next-day delivery. This ensures that you can start or continue your hormone replacement therapy without any unnecessary delays.

Frequently Asked Questions About Sandrena Gel

Will Sandrena Impact My Ability to Drive?

No studies have been conducted on whether Sandrena gel will impact your ability to drive or operate machinery.

If you experience any side effects which impair your cognitive ability, such as drowsiness or dizziness, do not drive or operate machinery until you feel better.

Can I Drink Alcohol While Using Sandrena Gel?

It is safe to drink alcohol while using Sandrena gel. Avoid drinking more than 14 units of alcohol per week, as per the government’s guidelines.

What Should I Do If I Forget to Use Sandrena Gel?

If you forget to use Sandrena gel when you should, apply the missed dose as soon as you remember, unless it has been more than 12 hours since your missed dose.

If it has been more than 12 hours since your last dose, skip the missed dose and continue to use Sandrena as you normally would.

Do not use more Sandrena gel to make up for the missed dose.

What Should I Do If I Use More Sandrena Gel?

If you accidentally apply more Sandrena gel than recommended, consult your doctor or a pharmacist.

Using too much Sandrena gel may increase your risk of side effects.

Does Sandrena Gel Cause Cancer?

Sandrena gel, like other oestrogen-based HRTS, may put you at an elevated risk of cancer of the womb or breast cancer. You should discuss your risk of cancer with your doctor.

You can find further information about the risk of cancer associated with HRTs within the patient information leaflet.

Do I Need a Prescription to Buy Sandrena Gel Online?

While we have online prescribers who can issue a private prescription for Sandrena gel, it is important to speak to your doctor before you begin hormone replacement therapy. Your doctor may need to conduct further assessments in person.

How Should I Store Sandrena Gel?

Store Sandrena gel at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets.

Can I Use Sandrena Gel During Pregnancy or Breastfeeding?

Sandrena gel is not recommended for use during pregnancy or breastfeeding. If you are pregnant, planning to become pregnant, or are breastfeeding, consult your doctor before using this medication.

Are There Any Foods or Medications That Interact With Sandrena Gel?

Some medications and foods may interact with Sandrena gel. It's important to inform your doctor about all medications, vitamins, and herbal supplements you are taking. Avoid grapefruit and grapefruit juice, as they may interact with the medication.

Can Men Use Sandrena Gel?

Sandrena gel is primarily formulated for women undergoing hormone replacement therapy. It is not recommended for men unless prescribed by a healthcare provider for specific medical conditions.

Sources

Orion Pharma Limited, 2018. Sandrena 0.5mg Gel: Summary of Product Characteristics

EMC, 2023. Sandrena 1.0 mg Gel: Product Information Leaflet.

NHS, 2023. About Oestrogen Tablets, Patches, Gel and Spray: NHS Official Guide.

NHS, 2023. How and When to Take or Use Oestrogen Tablets, Patches, Gel and Spray: NHS Official Guide.

NICE, 2023. Estradiol: NICE Official Resource.

PubMed, 2023. Effects of Transdermal Oestrogen Therapy in Postmenopausal Women: A Comparative Study.

Additional Resources

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How Long Does It Take for Sandrena Gel to Work?

Sandrena gel is a type of hormone replacement therapy (HRT) which can treat menopause symptoms, such as hot flushes. It contains the active ingredient estradiol (an artificial oestrogen), which replaces the decline in natural oestrogen to alleviate symptoms.If you have been prescribed Sandrena gel or want to know more about how long it takes for Sandrena gel to work, we explore this question in more detail below.Effectiveness of Sandrena Gel for MenopauseSandrena gel is an effective treatment, according to various medical studies. How long Sandrena takes to work will depend on your dosage and symptoms, as this is different for every person.Speed of ActionSandrena gel should start to alleviate symptoms when applied, but it can take a couple of days to a couple of weeks to reach its full effect.How Quickly Does Sandrena Gel Work?Sandrena gel should start to work immediately, but it may take a few days to a few weeks for your symptoms to improve.Treatment DurationYour doctor will only prescribe HRT for as long as you need it, typically around 2 to 3 years. You should continue taking Sandrena gel even if you feel better, as your symptoms may recur when you stop. You’ll have a yearly HRT check-up, during which you can discuss any symptoms with your doctor.How Long Does Sandrena Gel Take to Absorb?Sandrena gel is absorbed through the skin, allowing it to work quickly and enter the bloodstream. It usually takes around 20 to 30 minutes to fully absorb.How Long Does Sandrena Gel Take to Leave the System?It can take approximately 36 hours for half of the active ingredient to be eliminated from your body. This depends on:how long you’ve been taking Sandrena gelyour dosageyour body weightThe effects will start to lessen within a day of your last application unless you continue applying it.Dosage and Factors Affecting EfficacyThere are 3 doses of Sandrena gel: 0.5 mg, 1 mg, and 1.5 mg. You’ll only be prescribed what you need to effectively manage your symptoms, starting at the lowest dose. If you have other health conditions or take certain medications, this could affect how Sandrena gel works, so your doctor will prescribe the dose that best suits your current circumstances.What to Do If You Find the Dose IneffectiveIf you find that your current Sandrena gel dose is not effective, speak to your doctor. They may be able to increase your dose to see if this works.Look out for symptoms such as:high blood pressurechanges in breast tissuemigraine-type headachesThese could be signs of a more serious condition and require immediate medical attention.ConclusionIt generally takes Sandrena gel around 20 to 30 minutes to absorb. It can take a few days to a few weeks to get the best effect from this medication, so continue to take it for at least 1 month.If you have any additional questions or concerns, please consult your healthcare provider for personalised advice.Additional ResourcesHow Sandrena Gel Treats Menopause?What is the Maximum Dose of Sandrena Gel?What Are the Steps for Applying Sandrena Gel?10 Questions About the Menopause AnsweredSourcesEMC, Sandrena 1.0 mg Gel.NHS, About Oestrogen Tablets, Patches, Gel and Spray.NHS, How and When to Take or Use Oestrogen Tablets, Patches, Gel and Spray.NICE, Estradiol.PubMed, Effects of Transdermal Oestrogen Therapy in Postmenopausal Women.
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How Long Does It Take for Sandrena Gel to Work?
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What is the Correct Dosage of Sandrena Gel to Use?

Considering Sandrena gel for your menopause symptoms like hot flushes? This HRT contains the active ingredient estradiol.This article will clarify the correct dosage of Sandrena gel to use for effective treatment and minimal side effects. So, what is the right amount of Sandrena gel for you? Let's find out.Optimal Usage of Sandrena GelHow much Sandrena gel you should use depends on your prescription . You are likely to start at the lowest dose of 0.5 mg, which your doctor can increase to 1.0 mg if needed. The maximum daily dose of Sandrena gel is 1.5 mg.There are 2 sachet options available for Sandrena gel:0.5 mg (0.5 g sachet) or;1 mg (1 g sachet)How Can a 1.5 mg Daily Dose be Achieved with Sandrena Gel?You can make a daily dose of 1.5 mg of Sandrena gel in 2 ways:a 1 g sachet and a 0.5 g sachet3 x 0.5 g sachetsCan You Use Too Much Sandrena Gel?It’s unlikely to overdose on Sandrena gel, as it can be easily washed off. Speak to your doctor or pharmacist if you use more than the recommended amount.Exceeding the prescribed dosage of Sandrena gel can lead to a range of adverse symptoms, including bloating, irritability/anxiety, tender breasts, nausea or vomiting, and withdrawal bleeding.Missed Dose of Sandrena GelIf you miss a dose of Sandrena gel, you can:apply the dose as long as it’s less than 12 hours lateskip the dose if it’s more than 12 hours late, then continue treatment as normalMissing a dose may cause breakthrough bleeding, like a period.Dosage Specifics0.5 mg of Sandrena gel may be enough to ease your symptoms, and your doctor will always try to give you the lowest dose possible to reduce side effects. If you don’t think your dose is high enough or your symptoms are not getting better after a few weeks, speak to your doctor.When is the Best Time to Use Sandrena Gel?You can use Sandrena gel at any time, but try to stick to the same time each day.How Much Sandrena is Equivalent to Oestrogel?1.5 mg of Sandrena gel is equal to 2 pumps of Oestrogel.Other ConsiderationsPregnant or breastfeeding women should not use Sandrena gel. Certain medical conditions may recur or worsen, so inform your doctor if you have been diagnosed with any condition or are currently undergoing a diagnosis.Some medications may affect how Sandrena gel works, or vice versa, so your doctor may reduce your dose if you take certain medications.You can use HRT at any age, but only if you have been through menopause.ConclusionHow much Sandrena gel you should use depends on what you’ve been prescribed to manage your symptoms. This may change if you take certain medications or have another medical condition. You’ll usually be prescribed the lowest dose of 0.5 mg, which can be increased if necessary.If you have menopause symptoms that are impacting your life, speak to your doctor or one of our prescribers about a personalised HRT plan. You can also find out more information on HRT treatments or Sandrena gel on our website.Additional ResourcesHow Sandrena Gel Treats Menopause?How Long Does It Take For Sandrena Gel To Work?How To Use Sandrena Gel?10 Questions About the Menopause AnsweredSourcesEMC, Sandrena 1.0 mg Gel.NHS, About Oestrogen Tablets, Patches, Gel and Spray.NHS, How and When to Take or Use Oestrogen Tablets, Patches, Gel and Spray.NICE, Estradiol.
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What is the Correct Dosage of Sandrena Gel to Use?
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When and How To Apply Sandrena Gel?

Sandrena gel is a topical hormone replacement therapy (HRT) that is used to treat the symptoms of menopause. It can be hard to understand how to apply Sandrena gel correctly, especially if you have been prescribed it for the first time. However, it is essential to use this gel correctly to maximise its effectiveness while reducing the chances of side effects.This article provides a guide for the accurate application of Sandrena gel, a common HRT that contains synthetic oestrogen (estradiol) used to alleviate symptoms that occur after menopause.Understanding Sandrena Gel Dosage and Sachet SizesSachets of Sandrena gel commonly come in two sizes:0.5 g of gel containing 0.5 mg of estradiol1g of gel containing 1 mg of estradiolYour doctor can prescribe a daily dose of Sandrena gel at 0.5 mg, 1 mg, or 1.5 mg. Typically, your doctor will begin treatment at 0.5 mg and increase the dosage as required. It is essential to use only the dosage prescribed by your doctor.How to Apply Sandrena Gel for Best ResultsTo maximise absorption and therefore obtain the best results, apply Sandren gel as outlined below, or follow the instructions in your patient leaflet. There is no optimal time for applying Sandrena gel. However, it’s best to choose the same time each day and pick a time that allows you to follow the application steps properly.Before applying the gel, ensure the area of skin where you will apply it is clean and dry. This should be on your upper thighs or lower body.Useful tips to apply Sandrena Gel are as follows:Ensure your hands are clean and dry before handling the gel.Double-check the sachets to ensure you are applying the correct dosage.Spread the gel over an area roughly twice the size of your hand and gently rub it into your skin.Let the gel dry. This should take a few minutes.Wash your hands, and be especially careful not to touch your eyes with the gel.Do not clean the area where you applied the gel for at least one hour after application.Don’t let others touch the area until it is dry or you have cleaned it.You should never swallow Sandrena gel. If you swallow it by accident, do not worry; however, please contact your doctor.How Often Should Sandrena Gel Be Applied?You will be prescribed a daily dosage of Sandrena gel. Therefore, it should be applied once per day. If you accidentally apply too much, it is unlikely to cause an issue; however, if you are concerned, please consult your doctor for advice. Consistently using too high a dose may lead to side effects such as tender breasts, anxiety, bloating, and nausea. These should disappear once the dosage is reduced.Choosing the Best Area of Skin to Apply Sandrena GelFor maximum effectiveness, Sandrena should be applied to the upper thighs and lower body. It doesn’t matter whether you apply Sandrena gel to the inner or outer thigh. However, it is important to avoid the genitals and alternate between different sides of your body each day. Do not use the same area of skin two days in a row, and alternate between different sides of your body each day. This will help with absorption.It’s essential to apply Sandrena gel to the lower body. Applying it elsewhere increases the risk of side effects. Specific areas to avoid include:BreastsFaceIrritated skinIs Sandrena Gel Right For You?There are instances where you should not use Sandrena gel and should consult your healthcare provider. These include:Sandrena Gel Interactions with Other DrugsSandrena can affect treatments for other diseases like epilepsy, tuberculosis, HIV, and hepatitis C. You should always talk to your doctor about your current medication before using Sandrena gel.Sandrena Gel Complications Around SurgeryIt is essential to tell your surgeon that you are taking Sandrena gel as soon as possible. The gel has the potential to cause blood clots, which can become a complication during surgery. You may need to stop taking Sandrena gel for a month or more before your surgery, and you should only restart it after surgery, following further consultation with your surgeon.Avoid Sandrena Gel if Pregnant, Breastfeeding, or MenstruatingSandrena gel is only prescribed for post-menopausal women. If you become pregnant while using Sandrena, stop immediately and consult your doctor. Furthermore, Sandrena is not a contraceptive. So, if it has been less than twelve months since your last menstrual period and you are under fifty years old, you may still need to use contraception to avoid pregnancy.ConclusionCorrect application of Sandrena gel is essential to ensure its effectiveness and reduce side effects. You must follow the dosage outlined by your doctor and the guidelines described here or in the Sandrena gel patient leaflet.If you have menopause symptoms that are impacting your life, speak to your doctor or one of our prescribers about a personalised HRT plan. You can find more information on HRT treatments or Sandrena gel on our website.Additional ResourcesHow Sandrena Gel Treats Menopause?How Long Does It Take For Sandrena Gel To Work?How Much Sandrena Gel Should Be Used?10 Questions About the Menopause AnsweredSourcesEMC, Sandrena Gel EMC.NHS, About Oestrogen Tablets, Patches, Gel and Spray.NHS, How and When to Take or Use Oestrogen Tablets, Patches, Gel and Spray.NICE, Estradiol.
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When and How To Apply Sandrena Gel?
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10 Questions About the Menopause Answered

Menopause is a fact of life that many don't think about until they have to. Women in their reproductive years are often more concerned about birth control and STDs.Men don't experience menopause, although they do undergo similar age-related changes.In recent years, more women have started discussing menopause. Although they are more open about it, some are still left with questions.1.) What is the menopause?The menopause occurs in a woman after age-related declines in hormones cause her to stop menstruating. The main hormones that decline during menopause are oestrogen, progesterone and testosterone.A woman is considered to be fully in menopause after 12 months without menstruation. After this time, pregnancy is unlikely.2.) What age does the menopause hit?On average, women experience the menopause between the ages of 45 and 55. A woman may begin to experience fewer periods as she approaches menopause, or she may stop menstruating suddenly.One in 100 women hit menopause before age 40 - this is called premature menopause and is usually caused by ovarian failure, damage to the ovaries or surgical removal of the ovaries.3.) How long does the menopause last?On average, the menopause lasts about four years. The time leading up to menopause is called perimenopause, and the time after menopause is called post-menopause.Symptoms begin to develop during perimenopause and ease off during post-menopause.4.) What are the symptoms of the menopause?Some common symptoms are:changes in moodchillsdry skinhot flashesirregular periodsloss of breast fullnessnight sweatssleep problemsslow metabolism and weight gainthinning hairvaginal dryness5.) How is the menopause diagnosed?Doctors typically diagnose the menopause based on the description of the symptoms, though some women experience few symptoms.There are also home menopause test kits which can tell you if you are menopausal.6.) When is it safe to stop using contraceptive pills?The combined contraceptive pill can mask symptoms of the menopause, making it difficult to diagnose. Thus, it is recommended to stop taking combined contraceptive pills before the age of 50 and switch to another form of contraception, such as the progestogen-only pill, also known as the mini pill.Of course, condoms are the only contraceptive method which can prevent sexually transmitted diseases (STDs). They can be used after the menopause.7.) Can the menopause affect hair and skin?Yes. During the menopause, androgen levels increase. Androgens, such as testosterone, determine male characteristics, including facial and body hair. As a consequence, some women may notice an increase in unwanted facial and body hair.The drop in oestrogen and progesterone slows down hair growth, causing hair on the scalp to appear thin.Since the body stops making as much collagen during menopause, the skin loses elasticity and becomes dry. This can create sagging skin around the cheeks and jawline, as well as increase the appearance of wrinkles around the eyes.8.) Is it possible to delay the menopause?One study published in the Journal of Epidemiology and Community Health found that women who eat a diet rich in fish, legumes, beans, B12, and zinc reach menopause later than women whose diet contains simple carbohydrates, such as refined rice and pasta.Another US study showed that women who ate more low-fat milk products delayed menopause by over three and a half years. It's thought that enzymes in the cow milk could boost oestrogen levels.However, the findings of both studies only demonstrated a possible relationship between the factors, not a probable cause. That is to say that while diet may have an effect on the age at which women experience the menopause, there are several other factors to consider that could influence the cessation of the menstrual cycle, the primary indicator of menopause.9.) How does a partial hysterectomy affect the menopause?A partial hysterectomy removes just the womb, but the cervix and ovaries remain intact.Evidence indicates that women who undergo a partial hysterectomy are at an increased risk of ovarian failure and, hence, early menopause.It is not known if this is caused by the hysterectomy itself or another pre-existing cause.10.) Is there a cure for menopause?While there is no cure for the menopause, there are a variety of treatments to manage the symptoms.If you experience uncomfortable symptoms, there are treatments available to help manage them and bring relief.Hormone replacement therapy (HRT) is a common menopause treatment that's available online.After the menopause transition is complete, most symptoms either disappear or subside to a more manageable level. Women no longer have to worry about birth control or monthly menstrual cycles.They are now free to enjoy life on their own terms.
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10 Questions About the Menopause Answered

Treatment information

  • Product Name: Sandrena
  • Manufacturer: Orion Pharma Limited
  • Active Ingredient(s): Estradiol
  • Administration: Topical
  • Presentation: Gel
  • Available Strength: 0.5mg, 0.1mg
  • Exemption: Prescription Only
  • Dosage: Apply the gel once a day to the skin on your lower body or thighs.
  • Description: Sandrena gel is a topical HRT menopause treatment
  • Drug Class: Hormonal replacement therapy (HRT)
  • Alcohol Consumption: No influence
  • When Pregnant: Do not use while pregnant. Speak to your doctor for further information.
  • When Breastfeeding: Do not use while breastfeeding. Speak to your doctor for further information.
  • Related Drug: Oestrogel
  • Price: 24.99 GBP
  • https://www.prescriptiondoctor.com/storage/product_images_th/sandrena.jpg
Click here to view the Sandrena - Patient Information Leaflet

Authored & Reviewed By

Mohamed Imran Lakhi

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 27/05/2022 Reviewed on: 13/03/2024

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