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We deliver medications between Monday and Saturday. You can upgrade to Saturday delivery on Friday.

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You should receive a tracking number with your order which you can use this number to track your parcel online. This should give you a clear indication of where your parcel is. If you haven’t received your parcel in the time frame given by our couriers, contact your local depot to find out where it is. You can also contact our support team who will do this for you.

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You can pay for your order using credit, debit card and bank transfer.

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Treatment Information

Table of contents

Get Sandrena Gel Sachets Online

Sandrena Gel is a topical HRT that is used to treat the symptoms of menopause symptoms. It is used to replace the levels of oestrogen that tail off during menopause.

Sandrena is available in two strengths - 0.5mg and 1.0mg of estradiol. Each pack contains 28 sachets.

With Prescription Doctor, you can order Sandrena Gel Sachets online from a GPhC registered pharmacy. If your order is approved before 3pm on a weekday, our pharmacy can send it the same day for next-day delivery.

What is menopause?

Menopause is an inevitability for women. Usually occurring between the ages of 40 and 50, menopause signals the end of menstruation and fertility.

In some cases, premature menopause can be brought on by the surgical removal of the womb (hysterectomy) or ovarian failure.

Menopause symptoms last for between 2 to 10 years. In the UK menopause lasts for about 4 years on average.

A decline in the female sex hormone oestrogen (estrogen) is the cause of menopausal symptoms. This hormone is produced in the ovaries and has various effects on the body.

Low oestrogen levels cause symptoms such as:

  • Decreased muscle mass
  • Flushing
  • Headaches
  • Low sex drive
  • Memory problems
  • Muscle and joint pain
  • Night sweats
  • Palpitations
  • Recurrent UTIs
  • Sleep disturbances
  • Vaginal dryness

These symptoms can disrupt daily life and cause distress. If you are experiencing these symptoms and believe you are going through the menopause, speak to your doctor.

Sandrena gel replenishes the body with an oestrogen called estradiol. The estradiol is absorbed through the skin where it acts in the body in place of oestrogen.

There are tests to determine whether you are going through menopause. The SELFCheck Menopause Test is a quick and simple home test that can give you a result within a few minutes.

Your doctor can discuss hormonal replacement therapies (HRT) with you to treat the symptoms of menopause. Menopause treatments typically focus on replenishing the levels of the hormone that is in decline. For instance, Sandrena increases the levels of oestrogen in the body.

A doctor may prescribe a progestogen alongside an oestrogen to reduce the risk of endometrial hyperplasia or endometrial cancer while using Sandrena.

How Do I Use Sandrena Gel?

Sandrena Gel is applied directly to the skin of the lower body, such as the thighs.

The active ingredient, estradiol, is absorbed through the skin.

You should apply the gel on alternating sides of your body.

Rub the gel into your skin, ensuring to spread it evenly, and allow the area to dry.

Always wash your hands after applying the gel.

Side Effects and Cautions

Before using Sandrena gel, you must carefully read the patient information leaflet. This leaflet contains instructions on how to store and use the gel, as well as important information regarding the safety of Sandrena gel.

If you have any questions or concerns about any of the information presented in the patient information leaflet, feel free to discuss them with our online prescriber by using the “my chats” feature under your Prescription Doctor account.

Who should not use Sandrena Gel?

Sandrena is not suitable for everyone. If you are not sure whether Sandrena is suitable for you, consult your doctor.

Do not use Sandrena if you:

  • have or have ever had breast cancer
  • have cancer that is sensitive to oestrogens, such as endometrial cancer (cancer of the womb)
  • have any unexplained vaginal bleeding
  • have untreated endometrial hyperplasia
  • have or have ever had a blood clot in the vein (thrombosis)
  • have a blood clotting disorder
  • have or recently have had a disease relating to blood clots in the arteries (e.g. heart attack, stroke or angina)
  • have or have ever had liver disease or abnormal liver function test results that have not returned to normal
  • have a rare blood disorder called porphyria
  • are allergic to estradiol or any of the other ingredients listed in the patient information leaflet

If you notice any of the above conditions occurring while taking Sandrena, stop using it and speak to your doctor immediately.

Side effects

All medicines carry the risk of side effects, though not everybody gets them.

It’s important to familiarise yourself with the side effects listed in the patient information leaflet and to remain vigilant of any side effects.

Common side effects may include:

  • bleeding or spotting
  • breast pain or tenderness
  • changes in mood (including depression, nervousness or lethargy)
  • changes in weight
  • dizziness
  • flatulence
  • headache
  • hot flushes
  • itching of the skin, rash, pain, increased sweating, swollen feet and lower legs
  • nausea
  • stomach ache
  • vomiting

This is not a full list of side effects associated with Sandrena gel. A complete list of side effects can be found within the provided patient information leaflet enclosed with the medicine.

If you experience any side effects, regardless of whether they are listed above or in the patient information leaflet, inform your doctor as soon as you can.


Do not use Sandrena if you are allergic to estradiol or any of the other ingredients listed in the patient information leaflet.

If you experience an allergic reaction after using Sandrena gel:

  • Stop using the product
  • Speak to your doctor

In the case of severe allergic reaction, such as anaphylaxis, go straight to your nearest accident and emergency department. Remember to take the packaging and any remaining sachets with you so that doctors treating you know exactly what you took.

Pregnancy and breastfeeding

Do not use Sandrena if you are pregnant or breastfeeding.

If you become pregnant while using Sandrena, stop using the gel immediately and consult your doctor.

Sandrena is not a contraceptive. If fewer than 12 months have elapsed since your last period, or you are under 50 years old, you may still become pregnant. You may still need to use contraception such as condoms to prevent pregnancy.

Other safety information

Inform our online prescriber of all other medicines you are currently using, including medicines prescribed by your doctor, or bought over the counter, as well as any health and herbal supplements you are taking.

Never use Sandrena Gel past the expiry date printed on the packaging.

Always store Sandrena gel out of sight and reach from children and pets.

Store Sandrena gel sachets in the original packaging. They should be stored at room temperature.

Do not store Sandrena about 25°C.

Never throw away medicine via household or water waste. Take any unwanted or expired medicine to your local pharmacy and ask them to dispose of it safely on your behalf. These measures can help to protect the environment.

Frequently Asked Questions

Will Sandrena impact my ability to drive?

No studies have been conducted on whether Sandrena gel will impact your ability to drive or operate machinery.

If you experience any side effects which impair your cognitive ability, such as drowsiness or dizziness, do not drive or operate machinery until you feel better.

Can I drink alcohol while using Sandrena gel?

It is safe to drink alcohol while using Sandrena gel. Avoid drinking more than 14 units of alcohol per week, as per the government’s guidelines.

What should I do if I forget to use Sandrena gel when I should?

If you forget to use Sandrena gel when you should, apply the missed dose when you remember unless 12 hours have elapsed since your missed dose.

If it has been more than 12 hours since your last dose, skip the missed dose and continue to use Sandrena as you normally would.

Do not use more Sandrena gel to make up for the missed dose.

What should I do if I use more Sandrena gel than I should?

If you accidentally apply more Sandrena gel than you should, speak to your doctor or a pharmacist.

Using too much Sandrena gel may increase your risk of side effects.

Does Sandrena gel cause cancer?

Sandrena gel, like other oestrogen-based HRTS, may put you at an elevated risk of cancer of the womb or breast cancer. You should discuss your risk of cancer with your doctor.

You can find further information about the risk of cancer associated with HRTs within the patient information leaflet.

Do I need a prescription to buy Sandrena gel online?

While we have online prescribers who can issue a private prescription for Sandrena gel, it is important to speak to your doctor before you begin hormone replacement therapy. Your doctor may need to conduct further assessments in person.


Orion Pharma Limited, 2018. Sandrena 0.5mg Gel: Summary of Product Characteristics

Mohamed Imran Lakhi
This content has been written and checked for quality and accuracy by Mohamed Imran Lakhi Content Administrator Updated on: 02/06/2023 Next review: 02/12/2023

Treatment information

  • Product Name: Sandrena
  • Manufacturer: Orion Pharma Limited
  • Active Ingredient(s): Estradiol
  • Administration: Topical
  • Presentation: Gel
  • Available Strength: 0.5mg, 0.1mg
  • Exemption: Prescription Only
  • Dosage: Apply the gel once a day to the skin on your lower body or thighs.
  • Description: Sandrena gel is a topical HRT menopause treatment
  • Drug Class: Hormonal replacement therapy (HRT)
  • Alcohol Consumption: No influence
  • When Pregnant: Do not use while pregnant. Speak to your doctor for further information.
  • When Breastfeeding: Do not use while breastfeeding. Speak to your doctor for further information.
  • Related Drug: Oestrogel
  • Price: 24.99 GBP
Click here to view the Sandrena - Patient Information Leaflet

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