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Sandrena
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Treatment Information
![Mohamed Imran Lakhi]()
Table of contents
What is Sandrena Gel?
Sandrena Gel is a topical Hormone Replacement Therapy (HRT) designed to treat menopause symptoms by replenishing declining oestrogen levels.
It replaces the levels of oestrogen that decrease during menopause.
Available in two strengths: 0.5mg and 1.0mg of estradiol. Each pack contains 28 sachets.
Understanding Menopause Before Treating With Sandrena Gel
Understanding menopause is crucial before starting any treatment. It is a natural phase that ends fertility and menstruation, usually occurring between ages 40 and 50.
Menopause is an inevitable phase for women, signalling the end of menstruation and fertility.
Premature menopause can occur due to surgical removal of the womb (hysterectomy) or ovarian failure.
In the UK, menopause symptoms last for an average of 4 years, but can range between 2 to 10 years.
Symptoms and Causes:
- A decline in the female sex hormone oestrogen causes menopausal symptoms.
- Common Symptoms Include:
- Decreased muscle mass
- Flushing
- Headaches
- Recurrent UTIs
- Vaginal dryness
- And more...
Sandrena Gel Treatment Options:
Sandrena Gel replenishes the body with estradiol, a form of oestrogen. Consult your doctor for appropriate treatment options, including HRT.
- Sandrena Gel replenishes the body with an oestrogen called estradiol.
- There are tests like the SELF Check Menopause Test to confirm menopause.
- Your doctor can discuss Hormone Replacement Therapies (HRT) to treat symptoms.
- A doctor may also prescribe a progestogen alongside an oestrogen to reduce risks like endometrial hyperplasia or endometrial cancer.
How Do I Use Sandrena Gel?
Sandrena Gel is applied directly to the skin of the lower body, such as the thighs.
The active ingredient, estradiol, is absorbed through the skin.
You should apply the gel on alternating sides of your body.
Rub the gel into your skin, ensuring to spread it evenly, and allow the area to dry.
Always wash your hands after applying the gel.
Sandrena Gel Side Effects and Cautions
Before using Sandrena gel, you must carefully read the patient information leaflet. This leaflet contains instructions on how to store and use the gel, as well as important information regarding the safety of Sandrena gel.
If you have any questions or concerns about any of the information presented in the patient information leaflet, feel free to discuss them with our online prescriber by using the “my chats” feature under your Prescription Doctor account.
Who should not use Sandrena Gel?
Sandrena is not suitable for everyone. If you are not sure whether Sandrena is suitable for you, consult your doctor.
Do not use Sandrena if you:
- have or have ever had breast cancer
- have cancer that is sensitive to oestrogens, such as endometrial cancer (cancer of the womb)
- have any unexplained vaginal bleeding
- have untreated endometrial hyperplasia
- have or have ever had a blood clot in the vein (thrombosis)
- have a blood clotting disorder
- have or recently have had a disease relating to blood clots in the arteries (e.g. heart attack, stroke or angina)
- have or have ever had liver disease or abnormal liver function test results that have not returned to normal
- have a rare blood disorder called porphyria
- are allergic to estradiol or any of the other ingredients listed in the patient information leaflet
If you notice any of the above conditions occurring while taking Sandrena, stop using it and speak to your doctor immediately.
Side Effects
All medicines carry the risk of side effects, though not everybody gets them.
It’s important to familiarise yourself with the side effects listed in the patient information leaflet and to remain vigilant of any side effects.
Common side effects may include:
- bleeding or spotting
- breast pain or tenderness
- changes in mood (including depression, nervousness or lethargy)
- changes in weight
- dizziness
- flatulence
- headache
- hot flushes
- itching of the skin, rash, pain, increased sweating, swollen feet and lower legs
- nausea
- stomach ache
- vomiting
This is not a full list of side effects associated with Sandrena gel. A complete list of side effects can be found within the provided patient information leaflet enclosed with the medicine.
If you experience any side effects, regardless of whether they are listed above or in the patient information leaflet, inform your doctor as soon as you can.
Sandrena Gel Allergies
Do not use Sandrena if you are allergic to estradiol or any of the other ingredients listed in the patient information leaflet.
If you experience an allergic reaction after using Sandrena gel:
- Stop using the product
- Speak to your doctor
In the case of severe allergic reaction, such as anaphylaxis, go straight to your nearest accident and emergency department. Remember to take the packaging and any remaining sachets with you so that doctors treating you know exactly what you took.
Sandrena Gel During Pregnancy and Breastfeeding
Do not use Sandrena if you are pregnant or breastfeeding.
If you become pregnant while using Sandrena, stop using the gel immediately and consult your doctor.
Sandrena is not a contraceptive. If fewer than 12 months have elapsed since your last period, or you are under 50 years old, you may still become pregnant. You may still need to use contraception such as condoms to prevent pregnancy.
Other safety information
Inform our online prescriber of all other medicines you are currently using, including medicines prescribed by your doctor, or bought over the counter, as well as any health and herbal supplements you are taking.
Never use Sandrena Gel past the expiry date printed on the packaging.
Always store Sandrena gel out of sight and reach from children and pets.
Store Sandrena gel sachets in the original packaging. They should be stored at room temperature.
Do not store Sandrena about 25°C.
Never throw away medicine via household or water waste. Take any unwanted or expired medicine to your local pharmacy and ask them to dispose of it safely on your behalf. These measures can help to protect the environment.
Where Can I Buy Sandrena Gel Sachets Online?
At Prescription Doctor, we make the process of obtaining Sandrena Gel Sachets straightforward and secure. You can place an order online from a GPhC-registered pharmacy, ensuring that you're receiving a genuine and quality-assured product.
If you complete your order before 3pm on a weekday, our dedicated pharmacy team will dispatch it the very same day, offering you the convenience of next-day delivery. This ensures that you can start or continue your hormone replacement therapy without any unnecessary delays.
Frequently Asked Questions About Sandrena Gel
Will Sandrena Impact My Ability to Drive?
No studies have been conducted on whether Sandrena gel will impact your ability to drive or operate machinery.
If you experience any side effects which impair your cognitive ability, such as drowsiness or dizziness, do not drive or operate machinery until you feel better.
Can I Drink Alcohol While Using Sandrena Gel?
It is safe to drink alcohol while using Sandrena gel. Avoid drinking more than 14 units of alcohol per week, as per the government’s guidelines.
What Should I Do If I Forget to Use Sandrena Gel?
If you forget to use Sandrena gel when you should, apply the missed dose when you remember unless 12 hours have elapsed since your missed dose.
If it has been more than 12 hours since your last dose, skip the missed dose and continue to use Sandrena as you normally would.
Do not use more Sandrena gel to make up for the missed dose.
What Should I Do If I Use More Sandrena Gel?
If you accidentally apply more Sandrena gel than you should, speak to your doctor or a pharmacist.
Using too much Sandrena gel may increase your risk of side effects.
Does Sandrena Gel Cause Cancer?
Sandrena gel, like other oestrogen-based HRTS, may put you at an elevated risk of cancer of the womb or breast cancer. You should discuss your risk of cancer with your doctor.
You can find further information about the risk of cancer associated with HRTs within the patient information leaflet.
Do I Need a Prescription to Buy Sandrena Gel Online?
While we have online prescribers who can issue a private prescription for Sandrena gel, it is important to speak to your doctor before you begin hormone replacement therapy. Your doctor may need to conduct further assessments in person.
How Should I Store Sandrena Gel?
Store Sandrena gel at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets.
Can I Use Sandrena Gel During Pregnancy or Breastfeeding?
Sandrena gel is not recommended for use during pregnancy or breastfeeding. If you are pregnant, planning to become pregnant, or are breastfeeding, consult your doctor before using this medication.
Are There Any Foods or Medications That Interact With Sandrena Gel?
Some medications and foods may interact with Sandrena gel. It's important to inform your doctor about all medications, vitamins, and herbal supplements you are taking. Avoid grapefruit and grapefruit juice, as they may interact with the medication.
Can Men Use Sandrena Gel?
Sandrena gel is primarily formulated for women undergoing hormone replacement therapy. It is not recommended for men unless prescribed by a healthcare provider for specific medical conditions.
Additional Resources
Sources
Orion Pharma Limited, 2018. Sandrena 0.5mg Gel: Summary of Product Characteristics
EMC, 2023. Sandrena 1.0 mg Gel: Product Information Leaflet.
NHS, 2023. About Oestrogen Tablets, Patches, Gel and Spray: NHS Official Guide.
NHS, 2023. How and When to Take or Use Oestrogen Tablets, Patches, Gel and Spray: NHS Official Guide.
NICE, 2023. Estradiol: NICE Official Resource.
PubMed, 2023. Effects of Transdermal Oestrogen Therapy in Postmenopausal Women: A Comparative Study.
Authored & Reviewed By
Mohamed Imran Lakhi
MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.
Published on: 27/05/2022 Reviewed on: 26/10/2023
Published on: 27/05/2022 Reviewed on: 26/10/2023
Treatment information
- Product Name: Sandrena
- Manufacturer: Orion Pharma Limited
- Active Ingredient(s): Estradiol
- Administration: Topical
- Presentation: Gel
- Available Strength: 0.5mg, 0.1mg
- Exemption: Prescription Only
- Dosage: Apply the gel once a day to the skin on your lower body or thighs.
- Description: Sandrena gel is a topical HRT menopause treatment
- Drug Class: Hormonal replacement therapy (HRT)
- Alcohol Consumption: No influence
- When Pregnant: Do not use while pregnant. Speak to your doctor for further information.
- When Breastfeeding: Do not use while breastfeeding. Speak to your doctor for further information.
- Related Drug: Oestrogel
- Price: 24.99 GBP
Click here to view the Sandrena - Patient Information Leaflet
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