results found...

How Long Does It Take For Sandrena Gel To Work?

Sandrena gel is a type of hormone replacement therapy (HRT), which can treat menopause symptoms, such as hot flushes. It contains the active ingredient estradiol (an artificial oestrogen), which replaces the decline in natural oestrogen to alleviate symptoms.

If you have been prescribed Sandrena gel or want to know more about how long it takes for Sandrena gel to work, we explore this question in more detail below.

Effectiveness of Sandrena Gel for Menopause

Sandrena gel is an effective treatment, according to various medical studies. How long Sandrena takes to work will depend on your dosage and symptoms, as this is different for every person.

Speed of Action

Sandrena gel should start to alleviate symptoms when you apply it, but it can take a couple of days to a couple of weeks to reach its full effect.

How Quickly Does Sandrena Gel Work?

Sandrena gel should start to work straight away, but it may take a few days to a few weeks before your symptoms get better.

Treatment Duration

Your doctor will only prescribe HRT for as long as you need it, which is usually around 2 to 3 years. You should keep taking Sandrena gel even if you feel better, as your symptoms may come back when you stop. You’ll have a yearly HRT check-up where you can discuss symptoms with your doctor.

How Long Does Sandrena Gel Take to Absorb?

Sandrena gel is absorbed through the skin, which means it works quickly to get into your bloodstream. It usually takes around 20 to 30 minutes to fully absorb.

How Long for Sandrena Gel to Leave System?

It can take around 36 hours for half of the active ingredient to leave your body. This depends on:

  • how long you’ve been taking Sandrena gel
  • your dosage
  • your body weight

The effects will start to lessen within a day of your last application unless you continue applying it.

Dosage and Factors Affecting Efficacy

There are 3 doses of Sandrena gel: 0.5 mg, 1 mg, and 1.5 mg. You’ll only be prescribed what you need to effectively manage your symptoms, starting at the lowest dose. If you have other health conditions or take certain medications, this could affect how Sandrena gel works, so your doctor will prescribe the dose that best suits your current circumstances.

What to Do If You Find the Dose Ineffective

If you find that your current Sandrena gel dose is not effective, speak to your doctor. They may be able to increase your dose to see if this works.

Look out for symptoms such as:

  • high blood pressure
  • changes in breast tissue
  • migraine-type headaches

These could be signs of a more serious condition and require immediate medical attention.


It generally takes Sandrena gel around 20 to 30 minutes to absorb. It can take a few days to a few weeks to get the best effect from this medication, so continue to take it for at least 1 month.

If you have additional queries or worries, consult your healthcare provider for tailored advice.

Authored & Reviewed By

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 18/09/2023 Reviewed on: 01/11/2023
Customer Service