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How To Apply Sandrena Gel?

This article aims to provide comprehensive guidance on how and where to apply Sandrena gel, a hormone replacement therapy (HRT) containing synthetic oestrogen (estradiol).

Understanding the correct application is crucial for maximising its benefits and minimising potential side effects. Proper application not only enhances its effectiveness in alleviating menopausal symptoms like hot flushes but also ensures you get the most out of your treatment. Below, we look at how and where to apply Sandrena gel.

Usage and Application of Sandrena Gel

Sandrena gel typically comes in 2 sachet strengths:

  • 0.5 mg gel, which is a 0.5 g sachet
  • 1 mg gel, which is a 1 g sachet

Your doctor will prescribe the lowest amount needed to alleviate your menopausal symptoms, starting at 0.5 mg, and increasing to 1 mg if required. You can take a maximum daily dose of 1.5 mg.

How to Apply Sandrena Gel?

To apply Sandrena gel, follow these instructions or check your patient information leaflet. Only apply it on dry and clean skin and never swallow it.

Here are the steps to ensure proper application:

  1. Wash your hands and chosen area of skin thoroughly.
  2. Using the right amount of sachets, spread the gel on an area around 1 to 2 times as large as your hand.
  3. Let it dry for 3 to 5 minutes.
  4. Wash your hands again, avoiding contact with the eyes.
  5. Avoid washing the area for an hour, or longer if you can. Don’t let anyone else touch the skin until you’ve cleaned it or the gel has completely dried.

Should you Rub Sandrena Gel in?

Yes, Sandrena gel should be rubbed in gently.

When to Apply Sandrena Gel?

Proper application of Sandrena gel enhances its therapeutic benefits while minimising the potential for adverse side effects.

When is the Best Time to Apply Sandrena Gel?

Optimal Timing: It doesn’t matter what time of day you apply Sandrena gel, although it’s best to stick to the same time each day.

How Often Should Sandrena Gel Be Applied?

You should only apply Sandrena gel once per day. Applying it more than once won’t make it more effective, but could cause side effects such as anxiety, tender breasts, nausea, vomiting, and bloating.

Optimal Areas for Applying Sandrena Gel

For optimal effectiveness, Sandrena gel should be applied to the lower body or thighs. To ensure even distribution and absorption, it's advisable to alternate the side of your body where you apply the gel each day.

Areas to Avoid When Applying Sandrena Gel

While Sandrena gel is beneficial for treating menopausal symptoms, there are specific areas where it should not be applied:

  • Breasts: Applying the gel here could lead to unwanted side effects.
  • Irritated or Broken Skin: The gel may exacerbate irritation or interfere with the healing process.
  • Face: This area is particularly sensitive and not recommended for application.

Does Sandrena Gel Go on Inner or Outer Thighs?

The gel can be applied on the inner or outer thighs, as long as you avoid the genital area.

Special Considerations

Sandrena gel may interact with some medications, especially those for treating epilepsy, tuberculosis, HIV, and Hepatitis C. This could cause irregular bleeding, so speak to your doctor about any current medications before using Sandrena gel for the first time.


If you are due to have surgery, you may need to stop taking Sandrena gel 4 to 6 weeks before, as it could increase the risk of blood clots. Let your surgeon know and ask your doctor when you can start using Sandrena gel again.

Pregnancy, breastfeeding, and periods

Do not use Sandrena gel if you are:

  • pregnant
  • planning to become pregnant
  • breastfeeding

Wait for your period to end before using Sandrena gel if you’re changing from another form of HRT where you have a period.


Sandrena gel should be rubbed gently into the lower body or thighs, once per day. It can be used at any time, but try to stick to the same time each day.

If you have menopause symptoms that are impacting your life, speak to your doctor or one of our prescribers about a personalised HRT plan. You can also find out more information on HRT treatments or Sandrena gel on our website.

Authored & Reviewed By

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 19/09/2023 Reviewed on: 01/11/2023
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