Novofem

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Patient Reviews: How Novofem Has Made a Difference

Treatment Information

Table of contents:

What is Novofem HRT?

Novofem is a prescription HRT tablet used to relieve menopause symptoms, such as:

  • Hot flushes
  • Night sweats
  • Difficulty sleeping
  • Mood swings
  • Vaginal dryness
  • Reduced sex drive (low libido)

It comes in a 28-day calendar pack containing two types of tablets. The red tablet contains estradiol, a synthetic form of the female hormone oestrogen. The white tablet contains both estradiol and norethisterone, a synthetic progestogen.

What is Novofem Used For?

Novofem is prescribed to relieve menopause symptoms in postmenopausal women who still have an intact uterus. It can also be used to help protect against osteoporosis (thinning of the bones) in postmenopausal women at high risk of fractures, where other treatments are not suitable.

The progestogen in Novofem (norethisterone) is included specifically because oestrogen taken alone can thicken the lining of the womb, which increases the risk of womb cancer. Taking progestogen alongside oestrogen reduces this risk. Women who have had a hysterectomy (womb removal) would not typically be prescribed this type of combined HRT.

Novofem is not a contraceptive and will not prevent pregnancy. Women who could still become pregnant should use a reliable form of contraception alongside it.

How Do Novofem Tablets Work?

During menopause, the ovaries gradually produce less oestrogen. This drop in oestrogen is what causes the physical and psychological symptoms associated with the menopause, such as hot flushes, night sweats, mood changes and sleep problems. Novofem works by replacing this lost oestrogen with estradiol, a synthetic form that is chemically identical to the oestrogen the body produces naturally. This helps to restore hormonal balance and relieve symptoms.

However, oestrogen taken alone can cause the lining of the womb (the endometrium) to thicken, which increases the risk of womb cancer if left unregulated. The Million Women Study, which followed over 700,000 postmenopausal women in the UK, found that oestrogen-only HRT was associated with an increased risk of endometrial cancer compared to non-users. 

To reduce this risk, Novofem also contains norethisterone, a synthetic progestogen that mimics the effects of progesterone, preventing excessive growth of the womb lining. While it does not prevent the risk entirely, it reduces the risk significantly in women who have not had a hysterectomy (an operation to remove the womb).

Postmenopausal women are also at a greater risk of developing a condition called osteoporosis (thinning of the bones). This is because oestrogen plays an important role in maintaining bone density in women. By restoring oestrogen levels, Novofem helps to slow bone loss and reduce this risk.

How Long Does Novofem Take to Work?

Some women notice an improvement in symptoms within the first few weeks of starting Novofem, though it can take up to three months to feel the full benefit. It is also common to experience some side effects, such as headaches or breast tenderness, in the early weeks of treatment. These usually settle as your body adjusts.

If your symptoms have not improved after three months, speak to your prescriber. It may be that the dose or type of HRT needs to be reviewed.

How Effective is Novofem?

A two-year study published in Gynecological Endocrinology followed over 1,200 postmenopausal women, comparing several sequential HRT treatments for relieving menopause symptoms. One of the treatment cycles tested is very similar to Novofem's formulation: 1mg estradiol for 16 days, followed by 12 days of 1mg estradiol combined with 1mg norethisterone. This cycle was found to be effective in controlling hot flushes and other symptoms of menopause, with a favourable bleeding profile over two years.

This is reflected in Novofem's own product information, which states that relief of postmenopausal symptoms is achieved during the first few weeks of treatment.

Novofem's oestrogen dose also has good evidence for bone health. Randomised, double-blind, placebo-controlled studies found that 1mg estradiol, taken alone, helped prevent bone loss after the menopause, improving bone density by 2.8% in the spine, and 1.6% in the hip by between 1.6% and 2.5%, depending on the area measured, over two years. A separate placebo-controlled trial of 1mg oral estradiol in postmenopausal Chinese women found similar results, with significant increases in bone density at the spine and hip compared with placebo over 12 months.

How to Take Novofem Tablets

Take one tablet once a day, at roughly the same time each day. Tablets can be taken with or without food.

Novofem is taken sequentially according to the following schedule:

 

Days 

What to Take

1-16

One red tablet daily

17-28

One white tablet daily

 

Once you finish a pack, start the next one immediately without a break. A withdrawal bleed (similar to a period) will usually occur at the start of each new pack. If you are not switching from another HRT, you can start Novofem on any day that is convenient for you. If you are switching from another HRT, your prescriber will advise you on when to begin.

Your prescriber will aim to prescribe the lowest effective dose for the shortest time needed to manage your symptoms. If you feel the dose is too strong or too weak, speak to your prescriber.

What is the Best Time of Day to Take Novofem?

There is no specific recommended time of day to take Novofem. Take it at whatever time is easiest for you to remember, and try to keep to the same time each day.

What If I Take Too Many Novofem Tablets?

If you take more tablets than you should, speak to a doctor or pharmacist. Taking too much oestrogen may cause breast tenderness, nausea, vomiting, or irregular vaginal bleeding. Too much progestogen may cause low mood, tiredness, acne, or increased body or facial hair.

Novofem Missed Tablet Guidance

If you forget to take your tablet, take it within 12 hours of your usual time. If more than 12 hours have passed, skip the missed tablet and continue as normal the next day. Do not take two tablets to make up for a missed one, as this may increase the likelihood of breakthrough bleeding or spotting.

Novofem Side Effects and Cautions

Like all medicines, Novofem carries some risks and potential side effects, though not everyone will experience them. This section covers the most important things to be aware of before and during treatment.

Novofem HRT Side Effects

The most common side effects of Novofem are headache and breast tenderness. A full list of side effects by frequency is set out in the table below.

Very Common

(may affect more than 1 in 10 people)

Common

(may affect up to 1 in 10 people)

Uncommon

(may affect up to 1 in 100 people)

Rare

(may affect up to 1 in 1,000 people)

Breast tenderness
Headache

Abdominal pain
Aggravation of uterine fibroids
Dizziness
Flatulence
Fungal vaginal infection
Indigestion
Nausea
Itching
Oedema
Vaginal bleeding
Weight gain

Changes in libido
Gallstones
Hair loss
Migraine
Muscle cramps
Vomiting

Acne
Allergic reactions
Bloating
Diarrhoea
Nervousness
Uterine fibroid
Vertigo

 

It’s important to note that the above is not an exhaustive list of potential Novofem side effects. More information is provided within the Patient Information Leaflet. 

When to Stop Novofem HRT

If you notice any of the following adverse effects after you’ve started taking Novofem tablets, stop treatment immediately and seek medical attention:

  • Yellowing of the skin or whites of the eyes (jaundice), as these may be signs of a liver disease
  • Swollen face, tongue and/or difficulty swallowing or hives, together with breathing difficulties. These could be symptoms of an angioedema
  • Migraine-like headaches that happen for the first time
  • Signs of a blood clot (see the ‘serious risks’ section below)
  • A large rise in blood pressure (with symptoms such as tiredness, dizziness, or headaches)

You should also follow this course of action if you become pregnant while taking Novofem sequential HRT. 

Serious Risks Associated with HRT

The following conditions are reported more often in women using HRT than in women who do not. Your prescriber will discuss these risks with you before starting treatment, and will review them with you at least once a year.

  • Breast cancer: The risk increases with duration of use and becomes apparent within around three years of starting. After stopping, the risk reduces over time but may persist for ten or more years in women who used HRT for more than five years.
  • Endometrial cancer: Oestrogen taken without progestogen increases the risk of womb cancer. Novofem includes norethisterone to reduce this risk. Report any unexpected vaginal bleeding to your prescriber promptly.
  • Ovarian cancer: A slightly increased risk has been associated with HRT use, though ovarian cancer is much rarer than breast cancer.
  • Blood clots (venous thromboembolism): The risk is around 1.3 to 3 times higher in HRT users, particularly in the first year. Seek urgent medical attention if you notice painful swelling or redness in the legs, sudden chest pain, or difficulty breathing.
  • Heart disease: Women over 60 using combined HRT may have a slightly higher risk of heart disease than non-users.
  • Stroke: The risk is around 1.5 times higher in HRT users than non-users and increases with age.
  • Memory loss: There is some evidence of a higher risk in women who begin HRT after the age of 65.

Hypersensitivity and Allergies

Allergic reactions to Novofem are uncommon but can occur. Signs may include hives, itching, swelling, difficulty breathing, a drop in blood pressure, dizziness, or sweating. These could indicate a serious allergic reaction (anaphylaxis). If you experience any of these symptoms, stop taking Novofem and seek immediate medical attention.

If You Need to Have Surgery

If you are due to have an operation, tell your surgeon that you are taking Novofem. You may need to stop taking it four to six weeks before the procedure to reduce the risk of blood clots. Your prescriber will advise you when it is safe to restart.

Novofem HRT Warnings and Interactions

Do not take Novofem if any of the following apply to you. If you are unsure about any of these points, speak to your doctor before taking it.

  • Have excessive thickening of the endometrium (Endometrial hyperplasia) that is not being treated
  • Have a blood-clotting disorder
  • Have ever had a blood clot in a vein, such as in the legs or lungs
  • Have had a disease caused by blood clots in the arteries, such as a heart attack, stroke, or angina
  • Have, had, or suspect you may have breast cancer
  • Have, had, or suspect you might have endometrial cancer or any other oestrogen-dependent cancer
  • Have had a liver disease where your liver function tests have not returned to normal
  • Have a rare inherited blood condition called porphyria
  • Have a known allergy to estradiol, norethisterone acetate, or any other ingredient in Novofem
  • Have unexplained vaginal bleeding

Novofem Precautions

Tell your prescriber if you have ever had any of the following conditions before starting Novofem, as they may return or worsen during treatment:

  • Fibroids (non-cancerous growths in the womb)
  • Endometriosis (womb lining growing outside the womb)
  • High blood pressure
  • Diabetes
  • Gallstones
  • Migraines or severe headaches
  • Epilepsy
  • Asthma
  • Lactose intolerance: Novofem tablets contain lactose. Speak to your doctor before taking Novofem if you have an intolerance to some sugars.

This is not a full list of precautions. Read the Patient Information Leaflet carefully before starting treatment, and speak to your prescriber if you have any concerns about your medical history.

Novofem Interactions

Some medicines can interfere with how Novofem works, which may lead to irregular bleeding. These include:

  • Epilepsy medicines (such as phenobarbital, phenytoin, and carbamazepine)
  • Tuberculosis medicines (such as rifampicin and rifabutin)
  • HIV medicines (such as nevirapine, efavirenz, ritonavir, and nelfinavir)
  • Hepatitis C medicines (such as telaprevir)
  • Herbal remedies containing St John's Wort

Novofem may also affect other medicines, particularly the epilepsy medicine lamotrigine, where it may increase the frequency of seizures. The medication could also interact with the immunosuppressive treatment cyclosporine if used at the same time. Additionally, medicines containing the antifungal ketoconazole could increase the effects of Novofem HRT.

Tell your prescriber or pharmacist about all medicines you are taking, including those bought without a prescription and any herbal remedies. If you need a blood test, let your doctor or the laboratory know that you are taking Novofem, as it can affect certain test results.

Pregnancy and Breastfeeding

Novofem is for use in postmenopausal women only and should not be taken during pregnancy or while breastfeeding. If you become pregnant while taking Novofem, stop taking it immediately and contact your doctor.

Frequently Asked Questions About Novofem Tablets

Is Novofem a Low Dose HRT?

Novofem contains 1mg of estradiol, which is considered a standard starting dose for HRT rather than a low dose. Lower-dose preparations containing 0.5mg of estradiol are available and may be more suitable for some women, particularly those over 60. Your prescriber will recommend the lowest dose that effectively manages your symptoms.

Does Novofem Cause Weight Loss?

Weight gain is listed as a common side effect of Novofem, affecting up to 1 in 10 people. Weight loss is not an expected effect of treatment. If you notice significant changes in your weight after starting Novofem, mention this to your prescriber at your next review.

When Does a Period Start on Novofem?

A withdrawal bleed, similar to a period, usually occurs at the start of each new pack, a few days after finishing the white tablets. Some irregular bleeding or spotting is common in the first few months of treatment and usually settles over time.

If bleeding continues beyond six months, starts unexpectedly after six months of treatment, or continues after stopping Novofem, speak to your doctor promptly.

Will I Always Have a Period on Novofem?

Most women will have a monthly withdrawal bleed while taking Novofem, though this varies. In a post-marketing study, regular withdrawal bleeding occurred in 91% of women taking Novofem over six months. If your bleeding pattern changes unexpectedly, speak to your prescriber.

Can I Just Stop Taking Novofem?

It is advisable to speak to your prescriber before stopping Novofem. They can explain what to expect when stopping and discuss alternatives if needed. Some women find their menopause symptoms return when they stop HRT, and your prescriber can help you manage this.

How Do I Store Novofem Tablets?

Store Novofem below 25°C, away from direct light, and keep it in the original outer carton. Do not refrigerate. Keep it out of the sight and reach of children, and do not use it after the expiry date printed on the packaging.

Can You Buy Novofem Online?

Yes, you can buy Novofem online from a licensed and trusted pharmacy such as Prescription Doctor. Simply complete a brief questionnaire, and our experienced clinicians will determine whether the treatment is suitable for your circumstances. There’s no need for an appointment, so you can start a consultation at any time.

If approved, our General Pharmaceutical Council-registered pharmacy will dispatch your medication to your chosen UK address in plain packaging for complete discretion. Orders approved before 3pm on a weekday are also eligible for next-day delivery, giving you swift access to the treatment you need.

Additional Resources

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10 Questions About the Menopause Answered

Menopause is a fact of life that many don't think about until they have to. Women in their reproductive years are often more concerned about birth control and STDs.Men don't experience menopause, although they do undergo similar age-related changes.In recent years, more women have started discussing menopause. Although they are more open about it, some are still left with questions.1.) What is the menopause?The menopause occurs in a woman after age-related declines in hormones cause her to stop menstruating. The main hormones that decline during menopause are oestrogen, progesterone and testosterone.A woman is considered to be fully in menopause after 12 months without menstruation. After this time, pregnancy is unlikely.2.) What age does the menopause hit?On average, women experience the menopause between the ages of 45 and 55. A woman may begin to experience fewer periods as she approaches menopause, or she may stop menstruating suddenly.One in 100 women hit menopause before age 40 - this is called premature menopause and is usually caused by ovarian failure, damage to the ovaries or surgical removal of the ovaries.3.) How long does the menopause last?On average, the menopause lasts about four years. The time leading up to menopause is called perimenopause, and the time after menopause is called post-menopause.Symptoms begin to develop during perimenopause and ease off during post-menopause.4.) What are the symptoms of the menopause?Some common symptoms are:changes in moodchillsdry skinhot flashesirregular periodsloss of breast fullnessnight sweatssleep problemsslow metabolism and weight gainthinning hairvaginal dryness5.) How is the menopause diagnosed?Doctors typically diagnose the menopause based on the description of the symptoms, though some women experience few symptoms.There are also home menopause test kits which can tell you if you are menopausal.6.) When is it safe to stop using contraceptive pills?The combined contraceptive pill can mask symptoms of the menopause, making it difficult to diagnose. Thus, it is recommended to stop taking combined contraceptive pills before the age of 50 and switch to another form of contraception, such as the progestogen-only pill, also known as the mini pill.Of course, condoms are the only contraceptive method which can prevent sexually transmitted diseases (STDs). They can be used after the menopause.7.) Can the menopause affect hair and skin?Yes. During the menopause, androgen levels increase. Androgens, such as testosterone, determine male characteristics, including facial and body hair. As a consequence, some women may notice an increase in unwanted facial and body hair.The drop in oestrogen and progesterone slows down hair growth, causing hair on the scalp to appear thin.Since the body stops making as much collagen during menopause, the skin loses elasticity and becomes dry. This can create sagging skin around the cheeks and jawline, as well as increase the appearance of wrinkles around the eyes.8.) Is it possible to delay the menopause?One study published in the Journal of Epidemiology and Community Health found that women who eat a diet rich in fish, legumes, beans, B12, and zinc reach menopause later than women whose diet contains simple carbohydrates, such as refined rice and pasta.Another US study showed that women who ate more low-fat milk products delayed menopause by over three and a half years. It's thought that enzymes in the cow milk could boost oestrogen levels.However, the findings of both studies only demonstrated a possible relationship between the factors, not a probable cause. That is to say that while diet may have an effect on the age at which women experience the menopause, there are several other factors to consider that could influence the cessation of the menstrual cycle, the primary indicator of menopause.9.) How does a partial hysterectomy affect the menopause?A partial hysterectomy removes just the womb, but the cervix and ovaries remain intact.Evidence indicates that women who undergo a partial hysterectomy are at an increased risk of ovarian failure and, hence, early menopause.It is not known if this is caused by the hysterectomy itself or another pre-existing cause.10.) Is there a cure for menopause?While there is no cure for the menopause, there are a variety of treatments to manage the symptoms.If you experience uncomfortable symptoms, there are treatments available to help manage them and bring relief.Hormone replacement therapy (HRT) is a common menopause treatment that's available online.After the menopause transition is complete, most symptoms either disappear or subside to a more manageable level. Women no longer have to worry about birth control or monthly menstrual cycles.They are now free to enjoy life on their own terms.
Read more →
10 Questions About the Menopause Answered
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What are the 34 symptoms of the menopause?

Menopause is a pivotal event in women’s lives, due to its wide-reaching impact and the significant changes involved. If you’re approaching menopause or would like to better understand what to expect, researching potential symptoms is crucial. While not everyone might experience the same things, it’s still worth finding out as much information as possible.In this article, we’ll answer important questions such as “Am I going through menopause?” and “What are the 34 symptoms of menopause?”, as well as discuss some early signs to be aware of and explore the different medications you can take. Let’s begin.  [medical_form product_id="471" text="START YOUR MENOPAUSE CONSULTATION TODAY" type="button"] What Does Menopause Mean?Menopause is a natural part of the female ageing process and describes the stage in a woman’s life when her periods stop. This change is permanent, and women can no longer get pregnant after menopause. The time leading up to menopause is called perimenopause, or the menopausal transition.Some women experience a variety of menopausal symptoms, while others have mild symptoms or none at all. Many people consider the perimenopausal stage part of menopause, but true menopause isn’t confirmed until at least one year has passed since a woman’s last period.At What Age Does Menopause Begin?Menopause usually begins between the ages of 45 and 55. However, it can happen earlier than this and may not be age-related. Premature menopause, defined as occurring before the age of 40, and early menopause, which affects women from 40 to 44, have several possible causes.For example, some women experience early menopause because of surgeries that remove the womb (hysterectomy) or ovaries (oophorectomy). Early menopause may also be triggered by chemotherapy or genetic factors. Other potential contributors to premature and early menopause include:SmokingHigh blood pressureThyroid disease  What are the 1st Signs of Menopause?Menopause symptoms can vary significantly between women, making it harder to establish when the menopausal transition has begun. However, the early signs of menopause commonly include:Changes in the regularity of periodsHot flashesNight sweatsBladder incontinenceSleep problemsVaginal drynessMood changesBrain fogNot all women experience menopause symptoms, but around 75% have them to some degree. For some women, these symptoms are mild and can be managed with small lifestyle adjustments, while for others, they are more severe. The symptoms of menopause last an average of 7 years, though they can continue for over 10 years in some women.What are the 34 Symptoms of Menopause?The symptoms of menopause are diverse, and not every woman has the same experience. There are around 34 menopause symptoms, ranging from physical issues (like hot flashes and headaches) to emotional and cognitive problems (such as mood swings and memory loss). {add_product_block(471)} 1. Hot FlashesHot flashes, the most common type of menopause vasomotor symptom, are sudden, short bursts of heat that cause redness and flushing around the face, neck and chest. This can be very uncomfortable, and some women find hot flashes disrupt their daily lives. For some people, small changes in their daily routine can help manage hot flashes. However, others may require hormonal or non-hormonal medications to reduce their symptoms.2. Period ChangesChanges in periods are a common sign of perimenopause and a result of fluctuating hormone levels. As women enter the menopausal transition, their ovaries start producing different amounts of oestrogen and progesterone, which play key roles in regulating menstruation.Your periods may become less regular, with cycles that are heavier, lighter, longer, or shorter than they used to be. Some women have periods that occur very close together, while others may skip a few months. Irregular periods continue for 2-8 years before stopping altogether.  3. Night SweatsHot flashes that happen at night are called night sweats. Some women with night sweats wake frequently, which can significantly disrupt sleep. It may be possible to manage night sweats with small dietary and lifestyle changes, or with prescription hormonal or non-hormonal medication.4. Poor Sleep QualityPoor sleep quality is a common issue for women experiencing menopausal transition. Many symptoms, such as night sweats and mood changes, can interrupt sleep and contribute to chronic sleep problems, like insomnia. Developing healthier sleep habits may help to improve sleep quality, as can medications like melatonin.5. Heart Palpitations Heart palpitations (which are rapid, irregular, or exaggerated heartbeats) affect up to 42% of perimenopausal women and 54% of postmenopausal women. This is another example of a vasomotor symptom, and studies have shown that cognitive behavioural therapy (CBT) can improve palpitations, night sweats, and hot flashes. Maintaining a healthy diet, frequent exercise, managing anxiety, and avoiding alcohol may also help to reduce heart palpitations.6. HeadachesHeadaches and migraines can change in severity and frequency during menopause. For some women, migraine symptoms worsen during the menopausal transition, possibly as a result of fluctuating oestrogen levels. Other types of headaches (like cluster and tension headaches) may also increase during menopause.   7. Mood SwingsMenopause is often associated with sudden mood swings, which can cause intense and unpredictable shifts in emotional state. Other mental health problems that can flare up during menopause include anxiety, depression, and stress. Alterations to mental well-being can happen because of changing hormone levels, but can also be exacerbated by sleep problems.8. Vaginal DrynessHormone fluctuations during the menopausal transition can bring about physical changes in the vagina. The inner lining of the vagina can become thinner, causing symptoms like vaginal dryness, burning, itching, and irritation. Genitourinary symptoms (i.e., symptoms affecting the genitals and urinary tract) affect an estimated 50-75% of women going through menopause.9. Memory LossMany menopausal women experience memory issues and brain fog, possibly because of declining oestrogen levels. This affects several aspects of cognitive function, including working memory, attention, processing speed, and verbal memory. Fortunately, many women find their memory problems improve after menopause, once their hormone levels stop fluctuating.10. TirednessSleep problems and hormonal fluctuations during the menopausal transition leave many women feeling fatigued. One study found that 46.5% of perimenopausal women and 85.3% of post-menopausal women felt physically and mentally exhausted, compared with just 19.7% of pre-menopausal women.  11. Loss of Sex DriveLoss of sex drive is common during menopause, as declining hormone levels can reduce libido. It may take longer to become aroused, and vaginal dryness can make sex uncomfortable or even painful. Other menopause symptoms, like poor sleep quality and mood changes, can also contribute to a lack of interest in sex.12. DepressionMenopause can increase your risk of depression, with one large study reporting rates of 35.6% among menopausal women. Doctors think this is due to changes in hormone levels, which have been associated with depression, irritability, and anxiety. Women who experience vasomotor symptoms (like hot flashes and sleep problems) are more likely to develop depression during menopause.13. AnxietyThe fluctuating hormone levels that characterise menopause may affect serotonin and Gamma-Aminobutyric Acid (GABA) signalling in the brain. This can contribute to mood changes during menopause, including depression and anxiety. Other menopause symptoms, like lack of sleep, can further exacerbate anxiety.14. Weight GainMany women gain weight during the menopausal transition. Weight gain often begins a few years before menopause and continues at about 1.5 pounds per year. However, hormonal changes alone don’t cause weight gain, and it’s usually due to a combination of factors, including ageing, lifestyle, and genetics. If you'd like to know more about losing weight during the menopause, please read our dedicated article.   15. Joint PainsJoint pain affects more than half of women going through menopause, as declining oestrogen levels can increase inflammation in the joints. Low oestrogen levels can also weaken muscle and bone, increasing the risk of osteoarthritis. You may be able to improve joint health and limit pain with low-impact exercise, strength training, and daily stretching.16. Poor ConcentrationPoor concentration, or ‘brain fog,’ affects many women experiencing menopausal transition. Oestrogen has neuroprotective effects, so declining levels may contribute to cognitive issues. Other menopause symptoms, like poor sleep quality and depression, can also impair concentration.17. Hair LossMenopause can cause changes to hair, as low oestrogen levels can impact the health of hair follicles. This may lead to thinning, loss of volume, and changes in hair texture. This phenomenon, called female pattern hair loss, may affect up to 56% of post-menopausal women.18. DizzinessDizziness is one of the most common symptoms of menopause, with 35.7% of women experiencing this symptom weekly. This may be linked to other menopause symptoms, such as anxiety and hot flashes. 19. Urinary Tract InfectionsUrinary tract infections are common among women in all life stages, but their prevalence increases after menopause. This may be because lower oestrogen levels impact the health and function of the vaginal mucosal wall. Thinning of the vaginal wall, impaired immune function and changes in the vaginal microbiota can all increase the risk of UTIs.  20. BloatingMany women experience digestive symptoms during menopause, including acid reflux, abdominal pain, bloating, constipation, and diarrhoea. Bloating is the most common of these symptoms, affecting an estimated 77% of menopausal women. Bloating is caused by a build-up of gas and is often linked to hormonal changes.21. Taste ChangesMenopause can alter taste perception, with some women reporting a reduction in the intensity of sweet and bitter flavours. This effect may have multiple causes, but it is linked to hormonal fluctuations and decreased salivary production during menopause.22. Urinary IncontinenceUrinary incontinence affects over 50% of post-menopausal women and is the most common symptom of Genitourinary Syndrome of Menopause (GSM), a cluster of conditions affecting the genitals and urinary tract. Declining estrogen levels can weaken urogenital tissues, including those supporting the bladder, and lead to urinary urgency and incontinence.23. Digestive IssuesDigestive problems such as diarrhoea, constipation, nausea, vomiting, abdominal pain, bloating, heartburn, and faecal incontinence may be more prevalent among menopausal women than pre-menopausal women. Oestrogen and progesterone play key roles in gastrointestinal health, so declining hormone levels may contribute to digestive issues in menopausal women.24. Muscle StrainMenopause has a profound effect on musculoskeletal health, and more than 70% of menopausal women report musculoskeletal symptoms like muscle strain. Researchers believe that reduced oestrogen levels can lead to a loss of muscle and bone mass, contributing to conditions that affect these tissues. {add_product_block(304)} 25. Dry & Itchy SkinHormonal changes during menopause can make skin thinner and drier.  This is because oestrogen supports skin health, and declining levels can contribute to dryness, which leaves skin feeling tight, flaky, and itchy.26. Change in Body OdourMany women find that their body odour gets stronger during menopause. This may be because a drop in oestrogen levels leaves the body with a relatively higher testosterone level, which can alter the skin's bacterial population. It may attract more bacteria, making sweat smell even stronger. Hot flashes and night sweats can also increase the number of bacteria in the armpits, further contributing to body odour.27. Brittle NailsChanges in oestrogen levels during menopause can affect nail health, making nails more brittle. This is because drops in oestrogen weaken the keratin layers in fingernails, causing them to break more easily. Dehydration can further weaken keratin and contribute to nail breakage, peeling, cracks and splits.28. AllergiesHormonal fluctuations women experience during menopause may contribute to the development of allergies. A reduction in oestrogen levels during menopause can also exacerbate asthma symptoms or lead to the development of asthma in women who didn’t previously have the condition.  29. Electric Shocks Under the SkinDeclining hormone levels during menopause can cause neurological symptoms and odd sensations. These can manifest as electric-shock sensations, which feel like sudden jolts or zaps under the skin. Many women also report experiencing paresthesia, or pins and needles.30. Breast TendernessBreast pain, or mastalgia, affects up to 70% of women and is a common symptom of menopause. Hormonal changes can cause breasts to feel more tender than usual, and they may feel lumpier than they did before. These symptoms often resolve after menopause, when hormone levels drop.31. TinnitusAlmost one-third of women experience new or worsening tinnitus during menopause, and doctors believe declining oestrogen levels are the cause. Oestrogen supports ear health, so having less of it can contribute to tinnitus. Other symptoms like anxiety, lack of sleep, and depression can also make tinnitus worse during menopause.32. Tingling Sensation in ExtremitiesHormonal changes during menopause can manifest as neurological symptoms, including paresthesia - an abnormal tingling or prickling sensation also known as ‘pins and needles.’ Many women experience this sensation in their hands and feet during menopause, though it is usually short-lived.33. OsteoporosisOsteoporosis is a serious medical condition that weakens bones to the point that they become fragile and break easily. The risk of osteoporosis increases with age, but menopausal women are more likely to develop the disease than men. This is because bone mass decreases around menopause, and women may lose up to 10% of their bone density in the 5 years after their periods stop. {add_product_block(453)} 34. Bleeding GumsFluctuating hormone levels can contribute to oral health problems, including dry mouth (xerostomia), gum disease, burning mouth syndrome (BMS), and changes in taste perception. Gum disease can cause gums to bleed, especially when brushing or flossing.How to Manage the Symptoms of MenopauseMost symptoms of menopause are related to natural ageing and the low levels of sex hormones (oestrogen, progesterone and testosterone) a woman produces, as she reaches the menopause period of her life. However, there are several ways you can manage some of these symptoms during menopause, and they include:Hormone replacement therapy (HRT)Medications like antidepressants can help with mood and depression Using lubricants for vaginal dryness Taking calcium and vitamin D supplements to help with weak bones.Lifestyle changes like exercising and eating a healthy diet  A few years post menopause, most symptoms should reduce and eventually stop. However, you should speak to your GP about troublesome issues and discuss treatments to manage menopausal symptoms.What Medication Can I Take for the Menopause?Menopause can produce a wide variety of symptoms affecting many aspects of physical and mental health. Some women go through menopause with no noticeable symptoms, while others have mild symptoms that they can manage with simple lifestyle adjustments. However, a number of women experience severe symptoms that disrupt their daily lives and require medication to reduce their impact.Oestrogel: Oestrogel is a topical hormone replacement therapy (HRT) that contains estradiol (i.e., oestrogen) as its active ingredient. This can counter the drop in hormone levels associated with menopause and help to alleviate symptoms like headaches, hot flashes, mood swings, heart palpitations, and more.Utrogestan: Utrogestan is a form of progesterone HRT. It should be used alongside an oestrogen-based HRT and can help to improve menopause symptoms by compensating for declining hormone levels.Estradot: Estradot is an HRT transdermal patch that contains estradiol, the primary form of oestrogen. The patches can be worn twice weekly to relieve hot flashes and night sweats, mood swings, vaginal dryness, and sleep problems.Evorel: Evorel HRT patches contain synthetic hormones that mimic the effects of oestrogen and progesterone. Users can apply the patches twice a week to rebalance hormones and improve menopause symptoms.Bijuve: Bijuve is an HRT medication containing both oestrogen and progesterone. These daily capsules supplement low hormone levels in menopause to relieve symptoms, including hot flushes, irritability, joint pains, and more.The hormonal changes brought about by menopause can manifest in diverse symptoms affecting many aspects of women’s physical, mental, and cognitive health. Prescription Doctor has a wide range of medications that can help to improve symptoms and quality of life by mitigating the effects of low oestrogen and progesterone levels.Support at Every StepIf you think you may be going through menopause or require some more advice, Prescription Doctor is here to help. Our dedicated team is available to support you at every stage, to help make the process as stress-free as possible.We strive to facilitate access to healthcare and give patients more control over how they obtain treatment. With us, there’s no need for face-to-face appointments that can take several days to arrange. Instead, you can fill out our online consultation form from your own home at any time. This makes obtaining a menopause test kit or ordering medication much more straightforward.Once the form has been completed, our specialist clinicians will review your information and determine whether your order is suitable for your circumstances. All orders approved before 3pm on a weekday are eligible for next-day delivery, while everything we dispatch is stored in plain packaging for complete discretion.To find out more about how Prescription Doctor can help you, or to request treatment, complete our consultation form today.  SourcesNIH (2024): What Is Menopause?PubMed (2023): Age at Natural Menopause and Influencing Factors in Women Attending the Gynaecological Outpatient Clinic at a Tertiary Care Hospital. PubMed (2025): Trends in age at natural menopause and menarche and related factors in Iran: results from a population-based study. NHS (2022): Menopause. BBC News (2024): What is the menopause and what are the main symptoms?NIH (2023): Menopause. NHS: Menopause for partners. NIH (2021): Hot Flashes: What Can I Do?Office on Women’s Health (2025): Menopause basics. Mayo Clinic (2024): Menopause. NIH (2021): Sleep Problems and Menopause: What Can I Do?PubMed (2022): Correlates of palpitations during menopause: A scoping review. British Heart Foundation (2023): Menopause and your heart. NHS Inform (2022): Menopause and your mental wellbeing. PubMed (2018): The Dynamics of Stress and Fatigue across Menopause: Attractors, Coupling and Resilience. PubMed (2025): Cognitive Function in Peri- and Postmenopausal Women: Implications for Considering Iron Supplementation. BUPA (2025): Does the menopause cause memory loss? Office on Women’s Health (2025): Menopause and sexuality. ScienceDirect (2024): Global prevalence of depression in menopausal women: A systematic review and meta-analysis. PubMed (2023): Does menopause elevate the risk for developing depression and anxiety? Results from a systematic review. Mayo Clinic (2023): The reality of menopause weight gain. PubMed (2023): Arthralgia of menopause - A retrospective review. BUPA (2024): Are muscle aches and joint pains linked to the menopause?PubMed (2021): Menopause and cognitive impairment: A narrative review of current knowledge. PubMed (2023): The Menopausal Transition: Is the Hair Follicle “Going through Menopause”?NICE (2021): Female pattern hair loss (female androgenetic alopecia). PubMed (2018): Dizziness in peri- and postmenopausal women is associated with anxiety: a cross-sectional study. NHS (2022): Menopause Symptoms. PubMed (2025): Urinary tract infections after menopause. Women’s Health Concern (2025): Digestive health and menopause. PubMed (2024): Taste Changes and Salivary Flow Rate Disparities in Premenopausal and Postmenopausal Women: Exploring the Zinc Connection. PubMed (2019): Urinary incontinence in postmenopausal women – causes, symptoms, treatment. PubMed (2024): The Link Between Menopause and Urinary Incontinence: A Systematic Review. PubMed (2025): The volume and characteristics of research on gastrointestinal symptoms in ‘natural’ peri- and postmenopause: A scoping review. PubMed (2024): The musculoskeletal syndrome of menopause. NIH (2025): Skin Care and Ageing. PubMed (2019): Estrogen-deficient skin: The role of topical therapy. Harvard Health Publishing (2023): Why has my natural scent changed during perimenopause?Shropshire Council: Menopause symptoms and practical tips to manage them. PubMed (2024): The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults. PubMed (2015): Estrogen Signalling Modulates Allergic Inflammation and Contributes to Sex Differences in Asthma. PubMed (2023): Perimenopause as a neurological transition state. NIH (2025): Mastalgia. NIH (2024): Understanding Breast Changes and Conditions. UCI Health (2025): The surprising link between menopause and tinnitus. Tinnitus UK: Tinnitus and menopause. The Menopause Charity (2024): Join the dots: A-Z symptoms list.NIH (2022): Osteoporosis.  Victoria State Government: Menopause and osteoporosis. PubMed (2024): Menopause and Oral Health: Clinical Implications and Preventive Strategies. 
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What are the 34 symptoms of the menopause?

Treatment information

Product Name: Novofem
Manufacturer: Novo Nordisk
Active Ingredient(s): Estradiol and norethisterone acetate
Administration: Oral
Presentation: Tablets in a calendar pack
Available Strength: 1mg of estradiol (red tablets), 1mg of estradiol and 1mg of norethisterone acetate (white tablets)
Exemption: Prescription only
Application: Postmenopausal women with at least 6 months since their last natural period
Description: A combined hormonal treatment for the menopause
Drug Class: Hormone replacement therapy (HRT)
Alcohol Consumption: No influence
When Pregnant: Do not take Novofem
When Breastfeeding: Do not take Novofem
Price: 39.99 GBP

Click here to view the Novofem - Patient Information Leaflet

Authored & Reviewed By

Mohamed Imran Lakhi

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 28/02/2019 Re-Published on: 03/07/2026 Reviewed on: 03/07/2026

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