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This is why we also take steps to conceal your prescription products under two layers of packaging.
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Novofem is a prescription HRT tablet used to relieve menopause symptoms, such as:
It comes in a 28-day calendar pack containing two types of tablets. The red tablet contains estradiol, a synthetic form of the female hormone oestrogen. The white tablet contains both estradiol and norethisterone, a synthetic progestogen.
Novofem is prescribed to relieve menopause symptoms in postmenopausal women who still have an intact uterus. It can also be used to help protect against osteoporosis (thinning of the bones) in postmenopausal women at high risk of fractures, where other treatments are not suitable.
The progestogen in Novofem (norethisterone) is included specifically because oestrogen taken alone can thicken the lining of the womb, which increases the risk of womb cancer. Taking progestogen alongside oestrogen reduces this risk. Women who have had a hysterectomy (womb removal) would not typically be prescribed this type of combined HRT.
Novofem is not a contraceptive and will not prevent pregnancy. Women who could still become pregnant should use a reliable form of contraception alongside it.
During menopause, the ovaries gradually produce less oestrogen. This drop in oestrogen is what causes the physical and psychological symptoms associated with the menopause, such as hot flushes, night sweats, mood changes and sleep problems. Novofem works by replacing this lost oestrogen with estradiol, a synthetic form that is chemically identical to the oestrogen the body produces naturally. This helps to restore hormonal balance and relieve symptoms.
However, oestrogen taken alone can cause the lining of the womb (the endometrium) to thicken, which increases the risk of womb cancer if left unregulated. The Million Women Study, which followed over 700,000 postmenopausal women in the UK, found that oestrogen-only HRT was associated with an increased risk of endometrial cancer compared to non-users.
To reduce this risk, Novofem also contains norethisterone, a synthetic progestogen that mimics the effects of progesterone, preventing excessive growth of the womb lining. While it does not prevent the risk entirely, it reduces the risk significantly in women who have not had a hysterectomy (an operation to remove the womb).
Postmenopausal women are also at a greater risk of developing a condition called osteoporosis (thinning of the bones). This is because oestrogen plays an important role in maintaining bone density in women. By restoring oestrogen levels, Novofem helps to slow bone loss and reduce this risk.
Some women notice an improvement in symptoms within the first few weeks of starting Novofem, though it can take up to three months to feel the full benefit. It is also common to experience some side effects, such as headaches or breast tenderness, in the early weeks of treatment. These usually settle as your body adjusts.
If your symptoms have not improved after three months, speak to your prescriber. It may be that the dose or type of HRT needs to be reviewed.
A two-year study published in Gynecological Endocrinology followed over 1,200 postmenopausal women, comparing several sequential HRT treatments for relieving menopause symptoms. One of the treatment cycles tested is very similar to Novofem's formulation: 1mg estradiol for 16 days, followed by 12 days of 1mg estradiol combined with 1mg norethisterone. This cycle was found to be effective in controlling hot flushes and other symptoms of menopause, with a favourable bleeding profile over two years.
This is reflected in Novofem's own product information, which states that relief of postmenopausal symptoms is achieved during the first few weeks of treatment.
Novofem's oestrogen dose also has good evidence for bone health. Randomised, double-blind, placebo-controlled studies found that 1mg estradiol, taken alone, helped prevent bone loss after the menopause, improving bone density by 2.8% in the spine, and 1.6% in the hip by between 1.6% and 2.5%, depending on the area measured, over two years. A separate placebo-controlled trial of 1mg oral estradiol in postmenopausal Chinese women found similar results, with significant increases in bone density at the spine and hip compared with placebo over 12 months.
Take one tablet once a day, at roughly the same time each day. Tablets can be taken with or without food.
Novofem is taken sequentially according to the following schedule:
Days | What to Take |
|---|---|
1-16 | One red tablet daily |
17-28 | One white tablet daily |
Once you finish a pack, start the next one immediately without a break. A withdrawal bleed (similar to a period) will usually occur at the start of each new pack. If you are not switching from another HRT, you can start Novofem on any day that is convenient for you. If you are switching from another HRT, your prescriber will advise you on when to begin.
Your prescriber will aim to prescribe the lowest effective dose for the shortest time needed to manage your symptoms. If you feel the dose is too strong or too weak, speak to your prescriber.
There is no specific recommended time of day to take Novofem. Take it at whatever time is easiest for you to remember, and try to keep to the same time each day.
If you take more tablets than you should, speak to a doctor or pharmacist. Taking too much oestrogen may cause breast tenderness, nausea, vomiting, or irregular vaginal bleeding. Too much progestogen may cause low mood, tiredness, acne, or increased body or facial hair.
If you forget to take your tablet, take it within 12 hours of your usual time. If more than 12 hours have passed, skip the missed tablet and continue as normal the next day. Do not take two tablets to make up for a missed one, as this may increase the likelihood of breakthrough bleeding or spotting.
Like all medicines, Novofem carries some risks and potential side effects, though not everyone will experience them. This section covers the most important things to be aware of before and during treatment.
The most common side effects of Novofem are headache and breast tenderness. A full list of side effects by frequency is set out in the table below.
Very Common (may affect more than 1 in 10 people) | Common (may affect up to 1 in 10 people) | Uncommon (may affect up to 1 in 100 people) | Rare (may affect up to 1 in 1,000 people) |
|---|---|---|---|
| Breast tenderness Headache | Abdominal pain | Changes in libido | Acne |
It’s important to note that the above is not an exhaustive list of potential Novofem side effects. More information is provided within the Patient Information Leaflet.
If you notice any of the following adverse effects after you’ve started taking Novofem tablets, stop treatment immediately and seek medical attention:
You should also follow this course of action if you become pregnant while taking Novofem sequential HRT.
The following conditions are reported more often in women using HRT than in women who do not. Your prescriber will discuss these risks with you before starting treatment, and will review them with you at least once a year.
Allergic reactions to Novofem are uncommon but can occur. Signs may include hives, itching, swelling, difficulty breathing, a drop in blood pressure, dizziness, or sweating. These could indicate a serious allergic reaction (anaphylaxis). If you experience any of these symptoms, stop taking Novofem and seek immediate medical attention.
If you are due to have an operation, tell your surgeon that you are taking Novofem. You may need to stop taking it four to six weeks before the procedure to reduce the risk of blood clots. Your prescriber will advise you when it is safe to restart.
Do not take Novofem if any of the following apply to you. If you are unsure about any of these points, speak to your doctor before taking it.
Tell your prescriber if you have ever had any of the following conditions before starting Novofem, as they may return or worsen during treatment:
This is not a full list of precautions. Read the Patient Information Leaflet carefully before starting treatment, and speak to your prescriber if you have any concerns about your medical history.
Some medicines can interfere with how Novofem works, which may lead to irregular bleeding. These include:
Novofem may also affect other medicines, particularly the epilepsy medicine lamotrigine, where it may increase the frequency of seizures. The medication could also interact with the immunosuppressive treatment cyclosporine if used at the same time. Additionally, medicines containing the antifungal ketoconazole could increase the effects of Novofem HRT.
Tell your prescriber or pharmacist about all medicines you are taking, including those bought without a prescription and any herbal remedies. If you need a blood test, let your doctor or the laboratory know that you are taking Novofem, as it can affect certain test results.
Novofem is for use in postmenopausal women only and should not be taken during pregnancy or while breastfeeding. If you become pregnant while taking Novofem, stop taking it immediately and contact your doctor.
Novofem contains 1mg of estradiol, which is considered a standard starting dose for HRT rather than a low dose. Lower-dose preparations containing 0.5mg of estradiol are available and may be more suitable for some women, particularly those over 60. Your prescriber will recommend the lowest dose that effectively manages your symptoms.
Weight gain is listed as a common side effect of Novofem, affecting up to 1 in 10 people. Weight loss is not an expected effect of treatment. If you notice significant changes in your weight after starting Novofem, mention this to your prescriber at your next review.
A withdrawal bleed, similar to a period, usually occurs at the start of each new pack, a few days after finishing the white tablets. Some irregular bleeding or spotting is common in the first few months of treatment and usually settles over time.
If bleeding continues beyond six months, starts unexpectedly after six months of treatment, or continues after stopping Novofem, speak to your doctor promptly.
Most women will have a monthly withdrawal bleed while taking Novofem, though this varies. In a post-marketing study, regular withdrawal bleeding occurred in 91% of women taking Novofem over six months. If your bleeding pattern changes unexpectedly, speak to your prescriber.
It is advisable to speak to your prescriber before stopping Novofem. They can explain what to expect when stopping and discuss alternatives if needed. Some women find their menopause symptoms return when they stop HRT, and your prescriber can help you manage this.
Store Novofem below 25°C, away from direct light, and keep it in the original outer carton. Do not refrigerate. Keep it out of the sight and reach of children, and do not use it after the expiry date printed on the packaging.
Yes, you can buy Novofem online from a licensed and trusted pharmacy such as Prescription Doctor. Simply complete a brief questionnaire, and our experienced clinicians will determine whether the treatment is suitable for your circumstances. There’s no need for an appointment, so you can start a consultation at any time.
If approved, our General Pharmaceutical Council-registered pharmacy will dispatch your medication to your chosen UK address in plain packaging for complete discretion. Orders approved before 3pm on a weekday are also eligible for next-day delivery, giving you swift access to the treatment you need.
Product Name: Novofem
Manufacturer: Novo Nordisk
Active Ingredient(s): Estradiol and norethisterone acetate
Administration: Oral
Presentation: Tablets in a calendar pack
Available Strength: 1mg of estradiol (red tablets), 1mg of estradiol and 1mg of norethisterone acetate (white tablets)
Exemption: Prescription only
Application: Postmenopausal women with at least 6 months since their last natural period
Description: A combined hormonal treatment for the menopause
Drug Class: Hormone replacement therapy (HRT)
Alcohol Consumption: No influence
When Pregnant: Do not take Novofem
When Breastfeeding: Do not take Novofem
Price: 39.99 GBP
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