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How Long Does It Take For Trisequens To Work?

If you're grappling with menopause symptoms, you may have heard of Trisequens, a hormone replacement therapy (HRT) containing estradiol and norethisterone acetate. But the question on your mind might be: How long does it take for Trisequens to work? This article delves into the speed of action, treatment duration, and long-term considerations for Trisequens. Read on to find out when you can expect relief from your menopause symptoms.

Speed of Action

Trisequens begins to alleviate menopause symptoms within a few weeks reaching maximum effectiveness over a few months. Consistent daily intake at the same time enhances its efficacy.

How Quickly Does Trisequens Work?

You may start to notice improvements in your menopause symptoms after a few weeks of taking Trisequens, but it can take a few months to reach maximum effectiveness.

How Long Does Trisequens Take to Absorb

Trisequens absorption time is usually a few hours. The absorption rate does not affect Trisequens’ efficacy, as the medication needs to build up in your system to fully alleviate symptoms.

Treatment Duration

You can take HRT like Trisequens for as long as you need, which is usually around 2 to 5 years

How Long Trisequens Takes to Leave the System

Trisequens’ half-life (how long it takes for half of the medication to leave your body) is different for each active ingredient:

  • estradiol - 18 hours
  • norethisterone acetate - 10 hours

This means it will stay effective until your next dose is due.

Treatment Duration for Different Groups

If you’re taking Trisequens to reduce osteoporosis risk, you’ll need to take it for at least 5 years. If you’ve had surgery to remove your ovaries or early menopause, the treatment duration isn't counted until you reach 50.

Long-term Use

Like all medications, Trisequens can come with some risks when taken for a long time, but for most women, the benefits outweigh these risks.

How Long Can You Take Trisequens For?

The recommended treatment duration for Trisequens is around 2 to 5 years, but it can be taken for longer. You can always restart HRT again if you find your symptoms return after stopping.

Risks and Benefits of Long-term Use

Long-term HRT use can come with some risks, such as:

  • breast cancer
  • ovarian cancer
  • blood clots
  • heart disease
  • stroke
  • memory loss (after the age of 65)

These risks are rare and will decrease after you stop HRT.

Your doctor will make sure Trisequens is a low-risk medication for you before prescribing it. You should also have an annual HRT check-up and will be invited for mammogram screenings.

Dosage and Factors Affecting Efficacy

You’ll always be prescribed the lowest dose of Trisequens for the least time, to reduce any long-term risks. Your age should not affect how well Trisequens works. Other health conditions or medications could impact the effectiveness of Trisequens and your doctor will adjust your dose accordingly.

Taking Trisequens at the same time each day will improve its effectiveness.

What to Do If You Find the Dose Ineffective

If you find that your current dose of Trisequens is not alleviating your symptoms and you’ve been taking it for 3 months, speak to your doctor. They may adjust your dose or try a different medication.


It usually takes a few months for Trisequens to work and reach its maximum effectiveness. You can take Trisequens for as long as you need to, and taking it at the same time can improve how well it works.

If you need more information on the timing and dosage of Trisequens, speak to your doctor or one of our prescribers. You can also find more information on HRT treatments or Trisequens on our website.

Authored & Reviewed By

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 25/09/2023 Reviewed on: 01/11/2023
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