Benadryl Allergy

In Stock
Dosage
8mg
One a day 10mg
+
Package Type
12 Capsules
£5.99
14 Tabletrs
£7.70
+
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Treatment Information

Table of contents:

What is Benadryl Allergy?

Benadryl Allergy is a range of medicines that relieve symptoms of hay fever and other conditions, such as pet and dust allergies. Each contains an antihistamine and helps with symptoms such as sneezing, a runny nose, and watery eyes.

At Prescription Doctor, we offer two types of Benadryl Allergy products:

  • Benadryl Allergy One a Day: Contains 10 mg of cetirizine dihydrochloride
  • Benadryl Allergy Relief: Contains 8 mg of acrivastine

Both Benadryl Allergy Relief and Benadryl Allergy One a Day can also be used to treat the symptoms of urticaria (also known as hives), where the skin looks blotchy with white raised bumps (wheals) surrounded by redness.

How Does Benadryl Allergy Work?

When the body detects something harmful, such as an infection, it produces chemicals called histamines, which cause blood vessels to expand and the skin to swell, helping it protect itself. If you're allergic to something otherwise harmless, such as pollen, animal hair, or dust, your body may mistake it for a threat and release histamine, which binds to receptors throughout the body and causes symptoms like sneezing, a blocked nose, skin rashes, and watery eyes.

The active ingredients in Benadryl Allergy One a Day and Benadryl Allergy Relief are classified as selective H1 receptor antagonists, which means they specifically target the receptors that histamine binds to. Both cetirizine and acrivastine work by binding to these receptors, thereby preventing histamine from doing so and causing unwanted symptoms.

Unlike some antihistamines such as cinnarizine (found in the travel sickness medicine Stugeron) and diphenhydramine (the ingredient in Nytol sleep aids), cetirizine and acrivastine are non-drowsy and are less likely to make you feel sleepy.

How Long Does Benadryl Allergy Take to Work?

Benadryl Allergy One a Day and Benadryl Allergy Relief are fast-acting treatments for hay fever and other allergic reactions. You should start to feel better within 1 to 2 hours of taking acrivastine (Allergy Relief) and within an hour of using cetirizine (One a Day).

How Effective is Benadryl Allergy?

Both Benadryl Allergy Relief and Benadryl Allergy One a Day have been clinically proven to be effective against hay fever symptoms and other allergic reactions. Each active ingredient (acrivastine) and (cetirizine) has been noted to improve quality of life and work quickly to relieve ailments.

An analysis of four clinical trials found that cetirizine 5 mg and 10 mg provided significant symptomatic relief in adults with a history of perennial allergic rhinitis (PAR) when compared to a placebo. Compared with baseline, participants in the cetirizine group experienced a 23% to 52% improvement in symptoms after one week of therapy. Meanwhile, a reappraisal described cetirizine as clinically efficacious in allergic rhinitis and chronic spontaneous urticaria and as a first-choice antihistamine.

As for acrivastine, a randomised, double-blind trial found that 38% of participants taking 8 mg of acrivastine achieved a 50% reduction in allergic rhinoconjunctivitis symptoms within 60 minutes, compared with 17% using a placebo. The median time for a 50% reduction was 80 minutes for the acrivastine group and more than 120 minutes for placebo. A review of its pharmacological properties also described the medication as having a rapid onset of action, making it particularly useful for 'on demand' therapy.

How to Take Benadryl Allergy Tablets

Benadryl Allergy One a Day and Benadryl Allergy Relief are for oral use only. Swallow them whole with a glass of water, and take them with or without food. It's essential that you do not take more than the stated dose for each product.

The table below outlines the dosage requirements for both Benadryl Allergy Relief and Benadryl Allergy One a Day:

 

Medication

Dosage

Requirements

Benadryl Allergy One a Day

1 tablet once a day

Do not take more than 1 tablet in 24 hours

Benadryl Allergy Relief

1 capsule up to 3 times a day

Do not take more than 3 doses in 24 hours

 

If your hay fever or allergy symptoms persist or worsen, speak to your clinician for advice.

If You Forget to Take Benadryl Allergy

If you forget to take Benadryl Allergy tablets, take the next dose as needed, as long as you do not exceed the maximum dosage within a 24-hour period. Do not take a double dose to make up for one you have missed.

If You Take Too Many Benadryl Allergy Tablets

If you take more Benadryl Allergy tablets than you should, contact a doctor or visit your nearest accident and emergency department. Take the Patient Information Leaflet for your medication with you, along with any remaining tablets.

Benadryl Allergy Side Effects and Cautions

As with most medications, Benadryl Allergy One a Day and Benadryl Allergy Relief can cause side effects, though not everyone will experience them. Because they contain different active ingredients, each treatment has a different side effect profile.

If you experience any adverse reactions when taking Benadryl Allergy tablets, you can report them to your clinician or use the MHRA's Yellow Card scheme. Doing this could help provide more information about the treatment's safety.

Side Effects of Benadryl Allergy One a Day

The table below outlines some of the adverse reactions that can occur when taking Benadryl Allergy One a Day:

 

Common

(affects 1 to 10 users in 100)

Uncommon

(affects 1 to 10 users in 1,000)

Rare

(affects 1 to 10 users in 10,000)

  • Headache
  • Dizziness
  • Drowsiness
  • Restlessness
  • Dry mouth
  • Sore throat
  • Abdominal pain
  • Upset stomach
  • Diarrhoea
  • Nausea
  • Runny nose
  • Agitation
  • Unusual weakness
  • Feeling of general discomfort
  • Pins and needles
  • Aggression
  • Depression
  • Weight gain
  • Tremors
  • Muscle spasms
  • Tics
  • Sleeplessness

If you experience any of the following, stop taking the medication and seek immediate medical help:

  • Sudden onset of fever, reddening of the skin, many small pustules
  • Sudden signs of allergy such as rash, itching or hives, swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing, or trouble breathing
  • Bruising or bleeding more easily than normal
  • Convulsions or hallucinations
  • Loss of consciousness

If you develop these adverse reactions, stop taking the treatment and consult your clinician:

More information about possible side effects of Benadryl Allergy One a Day can be found within the Patient Information Leaflet that comes with the medication.

Side Effects of Benadryl Allergy Relief

The table below outlines possible adverse reactions when using Benadryl Allergy Relief:

 

Very Common

(may affect more than 1 in 10 people)

Common

(may affect up to 1 in 10 people)

  • Drowsiness
  • Dry mouth
  • Dizziness

 

If you notice swelling of the face, lips, mouth, tongue or throat that may cause difficulty in swallowing or breathing, stop taking the medicine and seek immediate medical help. If you develop a rash or other allergic reactions, cease treatment and talk to your clinician for advice.

For more information regarding the side effects of Benadryl Allergy Relief, read the Patient Information Leaflet enclosed with the medication.

Benadryl Allergy Warnings and Interactions

Although Benadryl Allergy Relief and Benadryl Allergy One a Day are effective treatments for hay fever and allergy symptoms, they may not be suitable for everyone. The table below shows circumstances where you should not take the medications:

 

Benadryl Allergy Relief

Benadryl Allergy One a Day

  • If you have ever had a bad reaction to any of the medication's ingredients
  • If you have ever had a bad reaction to the antihistamine triprolidine
  • If you have severe kidney disease
  • When drinking grapefruit juice
  • If you are aged over 65
  • If you have ever had a bad reaction to cetirizine dihydrochloride or any other ingredient
  • If you have ever had a bad reaction to hydroxyzine or piperazine derivatives
  • If you have serious kidney problems

 

If you're unsure about whether any of the above applies to you, speak to your clinician before starting the medication.

Precautions Before Taking Benadryl Allergy

Seek medical advice from your doctor or clinician before you take Benadryl Allergy tablets if any of the following criteria apply to you:

 

Benadryl Allergy Relief

Benadryl Allergy One a Day

  • You have kidney problems
  • You are taking sedatives or tranquillisers for anxiety or sleep disorders
  • You are taking ketoconazole for fungal infections
  • You are taking erythromycin for bacterial infections
  • You have an intolerance to some sugars, as this treatment contains lactose
  • You are epileptic or at risk of convulsions
  • You have kidney problems
  • You have difficulty passing urine
  • You have been told you are intolerant to some sugars, as this treatment contains lactose

 

Pregnancy and Breastfeeding Advice

If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your clinician or doctor before taking Benadryl Allergy. Do not take Benadryl Allergy One a Day 10 mg tablets during breastfeeding because cetirizine can pass into breast milk.

Frequently Asked Questions About Benadryl Allergy

What is Benadryl Allergy Used For?

Benadryl Allergy tablets are an antihistamine used to treat perennial and seasonal allergic rhinitis (including hay fever, dust mite allergies, and pet allergies). You can also use them for the treatment of allergic skin rashes, such as hives or urticaria.

Does Benadryl Affect Allergy Testing?

Yes, Benadryl Allergy tablets can affect allergy testing, so stop taking them before your test. It's recommended that you stop treatment 3 days before a skin allergy test, though some clinics advise longer. Consult with your clinic for more information.

Can You Use Benadryl Allergy for Rashes?

Yes, Benadryl Allergy tablets can be used to treat allergic skin rashes. These include urticaria, also known as hives, which causes the skin to look blotchy with white raised wheals that are surrounded by redness.

Is Benadryl Allergy an Antihistamine?

Yes, Benadryl Allergy tablets contain an antihistamine as an active ingredient. Benadryl Allergy One a Day has 10 mg of cetirizine dihydrochloride, while Benadryl Allergy Relief contains 8 mg of acrivastine.

Does Benadryl Allergy Make You Sleepy?

In most cases, Benadryl Allergy tablets do not cause drowsiness, though there are exceptions. Drowsiness or tiredness are listed as a common side effect of Benadryl Allergy One a Day, potentially affecting 1 to 10 users in 100. Meanwhile, drowsiness is listed as a very common side effect of Benadryl Allergy Relief, potentially affecting more than 1 in 10 people.

Can You Take Benadryl Allergy with Other Allergy Meds?

Yes, you can take Benadryl Allergy One a Day and Benadryl Allergy Relief with other hay fever treatments such as steroid nasal sprays and allergy eye drops. You should not use them alongside other antihistamines unless advised by a clinician.

Can I Drink Alcohol While Taking Benadryl Allergy?

As with all antihistamines, it is advised to avoid drinking alcohol while using Benadryl Allergy One a Day and Benadryl Allergy Relief tablets. Drinking alcohol while taking Benadryl can increase your risk of side effects such as dizziness, drowsiness and nausea.

Can I Drive or Operate Machines with Benadryl Allergy?

Always exercise caution when driving or operating machinery while taking Benadryl Allergy tablets. If the product makes you feel drowsy or dizzy, do not drive or use machines until you feel safe to do so.

Can You Buy Benadryl Allergy Over the Counter?

Yes, both Benadryl Allergy Relief and Benadryl Allergy One a Day tablets are available over the counter with no need for a prescription. You will still need to answer a few brief questions to ensure that the medication is suitable for your circumstances.

Can You Buy Benadryl Allergy Online?

Yes, you can buy Benadryl Allergy tablets online from trusted pharmacies such as Prescription Doctor. Simply complete a short medical questionnaire, and our clinicians will review your information to determine suitability. If approved, we dispatch your order from our General Pharmaceutical Council-registered pharmacy in plain packaging.

How Do I Store Benadryl Allergy Tablets?

Benadryl Allergy One a Day does not have any special storage conditions. Benadryl Allergy Relief must be kept dry and stored in the original packaging, below 30°C. Always store Benadryl Allergy tablets out of the sight and reach of children and do not use beyond the expiry date listed on the pack.

Treatment information

  • Product Names: Benadryl Allergy Relief & Benadryl Allergy One a Day
  • Manufacturer: McNeil Products Ltd
  • Active Ingredient(s): Acrivastine & Cetirizine dihydrochloride
  • Administration: Oral
  • Presentation: Film-coated tablets and capsules 
  • Available Strength: 8 mg & 10 mg 
  • Exemption: Available without prescription 
  • Dosage: Take 1 tablet daily (One a Day) or take 1-3 capsules daily (Allergy Relief) 
  • Description: Benadryl Allergy is an antihistamine used to treat symptoms of hay fever and other allergies 
  • Drug Class: Antihistamine
  • Alcohol Consumption: Do not drink alcohol while taking Benadryl.
  • When Pregnant: Speak to a clinician or doctor before starting treatment
  • When Breastfeeding: Speak to a clinician or doctor before starting treatment
  • Price: 5.99 GBPhttps://www.prescriptiondoctor.com/storage/product_images_th/benadryl.jpg
Click here to view the Benadryl Allergy - Patient Information Leaflet

Authored & Reviewed By

Mohamed Imran Lakhi

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 24/04/2020 Re-Published on: 10/09/2026 Reviewed on: 10/09/2026

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