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Understanding Oestrogel Side Effects

Oestrogel Pump is a type of Hormone Replacement Therapy (HRT) containing estradiol, a man-made version of the hormone oestrogen. It’s used to treat menopause symptoms, including hot flushes, sleeping difficulties, and anxiety, which happen because of a drop in your Oestrogel levels.

Like all medications, Oestrogel Pump can cause side effects in some people. This article discusses these side effects in more detail and what to do if you get side effects of Oestrogel Pump.

Overview of Oestrogel Side Effects

Oestrogel pump side effects can be split into 3 main categories: common, uncommon, and rare.

Common side effects of Oestrogel Pump include:

  • menstrual changes, such as irregular bleeding
  • vaginal discharge or itching
  • headaches
  • nausea
  • hair loss
  • weight gain

Uncommon side effects of Oestrogel Pump include:

  • changes in mood, such as mood swings or depression
  • a feeling of weakness
  • migraine
  • vaginal yeast infections, such as thrush

Rare side effects of Oestrogel Pump include:

  • severe allergic reaction (anaphylaxis)
  • high blood pressure
  • acne
  • unusual production of breast milk

A complete list of side effects can be found within the patient information leaflet.


Consider rephrasing to "Oestrogel Pump is not suitable for everyone; it should not be used by those who are pregnant or breastfeeding. You should also not use Oestrogel if you have:

  • allergies to any ingredient in the gel
  • known or suspected breast cancer
  • a history of blood clots or a blood clotting disorder
  • unexplained vaginal bleeding

You can still use Oestrogel Pump if you have certain medical conditions, but your doctor will need to know. Tell your doctor before using Oestrogel Pump if you have:

  • diabetes
  • gallstones
  • migraines
  • endometriosis
  • an increased risk of blood clots
  • asthma
  • epilepsy

Never take a new medication without consulting your doctor or a prescriber, who will ensure that Oestrogel is suitable for you.

Specific Concerns

Is Tiredness a Side Effect of Oestrogel?

Some people who take Oestrogel Pump may feel weak or tired. This can also be linked to symptoms of menopause, especially if you find it difficult to sleep.

Can Oestrogel Cause an Upset Stomach?

Oestrogel can cause wind (flatulence), which is an uncommon side effect. Some people have also reported nausea (feeling sick). Speak to your doctor if this does not go away and use Oestrogel after you’ve eaten to minimise these effects.

Duration of Oestrogel Side Effects

The duration of side effects from Oestrogel Pump varies from person to person. Mild side effects usually go away once your body gets used to regular treatment, somewhere between a few days to a few weeks. If your side effects persist, worsen, or impact your daily life, consult your doctor.

If you notice any serious or rare side effects, call 999 or go to A&E straight away.

Managing Oestrogel Side Effects

Below are some practical tips for managing common side effects of Oestrogel Pump:

  • headaches - drink plenty of fluids, get enough rest, and take painkillers
  • breast pain/tenderness - wear a supportive bra
  • vaginal itching - use an over-the-counter cream to reduce discomfort
  • menstrual changes - keep a menstrual diary and discuss these changes with your doctor, and take painkillers for painful periods

If you experience side effects for a prolonged time or aren’t sure how to best manage them, contact your doctor or nearest GP. You can also discuss your side effects with our medical team.


Although Oestrogel Pump can cause side effects, most of these will get better or go away entirely as your body adjusts. Side effects that persist, get worse, or are severe should be addressed straight away. Speak to your doctor, ask a pharmacist, or talk to one of our medical team for help.

Authored & Reviewed By

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 04/09/2023 Reviewed on: 01/11/2023
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