Mounjaro Before and After: Weight Loss Success Stories

Weight loss is undoubtedly a personal process. It’s different for everyone, and people have different aims – from gaining confidence to rediscovering old and new activities, playing more with their children or grandchildren, or simply reclaiming overall health.

Mounjaro (tirzepatide) has become something of a lifeline for many individuals seeking to lose weight in the long term. It can offer that all-important boost to your efforts, supporting your weight loss objectives while improving overall health. Indeed, clinical trials have shown that the medication could lead to a loss of 22.5% of your starting body weight at the highest maintenance dose. 

If you’ve been considering adding Mounjaro to your own weight loss regimen, you’ll likely want to know more about how the treatment could benefit you. There’s no better way to do this than by exploring Mounjaro before and after success stories from real people who have used the medication to change their lives for the better. Let’s get started. 

What Is Mounjaro and How Does It Work? A Quick Recap

Let’s very quickly recap Mounjaro and how it works. Originally developed to treat type 2 diabetes, Mounjaro has proven highly effective in helping people lose weight and keep it off for the long term.

It works by mimicking two key hormones – GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) – which play a role in regulating blood sugar levels and satiety (the feeling of fullness after eating).

By activating these receptors, Mounjaro helps reduce hunger, slows the emptying of food from the stomach, and enhances the body's ability to manage glucose levels, ultimately leading to sustained weight loss.

Without further discussion, let’s review ten real Mounjaro weight loss before and after stories and the people behind them.

User 1: 82 Pounds (37.2 kg) Down in 16 Months

• Starting Weight: 254 lbs (115.2 kg)
• Current Weight: 172 lbs (78.0 kg)
• Time Using Mounjaro/Wegovy: 1 year, 4 months
• Dosage: Gradual increases
• Total Weight Loss: 82 lbs (37.2 kg)

Over 16 months, this user lost 82 pounds (37.2 kg), steadily working their way down from 254 lbs to 172 lbs. They started Mounjaro on November 15, 2022, and then switched to Wegovy. With consistent effort, they steadily reached a much healthier weight and maintained their progress for a sizeable duration.

User 2: 203 Pounds (92 kg) Down in Under Two Years

• Starting Weight: 423 lbs (191.9 kg)
• Current Weight: 220 lbs (99.8 kg)
• BMI Change: 51.5 to 26.8
• Time Using Mounjaro: 1 year, 8 months
• Total Weight Loss: 203 lbs (92 kg)

For this user, Mounjaro saw them drop from a BMI of 51.5 – well into the “severely obese” range – to 26.8, an outstanding improvement in less than two years. They improved their diet by incorporating lean protein and vegetables, along with sugar-free gummy bears to help manage cravings.

User 3: 85 Pounds (38.5 kg) Down in 1 Year, 3 Months

• Starting Weight: Not specified
• Current Weight: Not specified
• Time Using Mounjaro: 1 year, 3 months
• Dosage: Max 7.5 mg
• Total Weight Loss: 85 lbs (38.5 kg)

This user started Mounjaro in December 2022 with insulin resistance, high blood pressure, and elevated cholesterol levels. By September 2023, they had lost 50 lbs (22.7 kg). Over the next six months, they lost another 35 lbs (15.9 kg), maintaining their progress since March 2024. Staying at 7.5 mg, they attempted 10 mg but found it intolerable. Now off all other medications, their lab results are within normal limits.

Feel inspired by this Mounjaro before and after success story? Begin your consultation with Prescription Doctor today. 

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User 4: 21 Pounds (9.5 kg) Down in 5 Weeks

• Starting Weight: 23.5 st (329 lbs / 149.2 kg)
• Current Weight: 22 st (308 lbs / 139.7 kg)
• Time Using Mounjaro: 5 weeks
• Dosage: 5 mg
• Total Weight Loss: 21 lbs (9.5 kg)

This user had already begun their weight loss journey before taking Mounjaro, but their progress was vastly accelerated once treatment had started. Indeed, they lost 1.5 stone (21 lbs / 9.5 kg) in just the first five weeks of using the medication.

Alongside a varied exercise regimen that incorporated things like pole fitness, gym sessions, and walking, they completely overhauled their diet. This was helped by the fact that Mounjaro helped them reduce cravings and improve their food choices. 

User 5: One Year, 88 Pounds (39.9 kg) Down

• Starting Weight: 214.8 lbs (97.4 kg)
• Current Weight: 126.8 lbs (57.5 kg)
• Time Using Mounjaro: 1 year
• Dosage: Not specified
• Total Weight Loss: 88 lbs (39.9 kg)

Over the course of a year, this user lost a massive 88 pounds (39.9 kg), reaching their goal weight. They focused on simple, repetitive meals instead of complex meal planning, which had previously made dieting difficult. Staying active by using an exercise bike supported their motivation. 

If these Mounjaro before and after pictures have got you thinking about trying the treatment yourself, you’ll need a prescription from a licensed prescriber. We offer a straightforward online consultation to help you get started with confidence. 

User 6: 47 Pounds (21.4 kg) Down in Just 3 Months

• Starting Weight: 251.6 lbs (114.1 kg)
• Current Weight: 204.5 lbs (92.8 kg)
• Target Weight: 190 lbs (86.2 kg)
• Time Using Mounjaro: 3 months
• Dosage: 5 mg
• Total Weight Loss: 47.1 lbs (21.4 kg)

This former athlete struggled with weight gain post-career, dealing with chronic joint pain, multiple knee surgeries, and gout. In just 90+ days on Mounjaro, they dropped 47 lbs (21.3 kg), going from 251.6 lbs (114.1 kg) to 204.5 lbs (92.8 kg). They revamped their diet and lifestyle, ditching carbs, sugar, and alcohol, focusing on single-ingredient foods – and adding plenty of walking to their routine. An incredibly strong start in a short space of time.

User 7: 34 Pounds (15.4 kg) Down

• Starting Weight: 215 lbs (97.5 kg)
• Current Weight: 181 lbs (82.1 kg)
• Target Weight: 137 lbs (62.1 kg)
• Time Using Mounjaro: Not specified
• Dosage: 7.5 mg
• Total Weight Loss: 34 lbs (15.4 kg)

Since starting Mounjaro, this user lost 34 lbs (15.4 kg), going from 215 lbs (97.5 kg) to 181 lbs (82.1 kg). Their Mounjaro before and after pictures were taken two months postpartum and as part of their most recent update. With steady progress, they were soon ready to start shopping for new clothes.

You can write your own Mounjaro success story by starting our online consultation. Our specialist pharmacists will assess your information to determine whether you’re a good candidate for the medication, and if approved before 3pm on a weekday, your order could be delivered the very next day. 

User 8: 60 Pounds (27 kg) Down and Maintaining

• Starting Weight: Not specified
• Current Weight: Not specified
• Time Using Mounjaro: 2 years
• Dosage: 15 mg for 1.5 years
• Total Weight Loss: 60 lbs (27.2 kg)

After two years on Mounjaro, this user lost 60 pounds (27.2 kg) in the first year and maintained their weight throughout the second. They had been on 15 mg for the past 1.5 years and continued feeling good with their results.

User 9: 95 Pounds (43 kg) Down in Just 6 Months

• Starting Weight: 144 kg (317 lbs)
• Current Weight: 101 kg (222 lbs)
• Time Using Mounjaro: 6 months
• Dosage: Not specified
• Total Weight Loss: 43 kg (95 lbs)

In just 6 months, this user lost 40 kg (88 lbs), dropping from 144 kg to 104 kg. After taking a break from dieting while travelling, they were surprised to find that they had maintained their weight, something that had never happened before. Upon returning home, they got back on track and dropped another 3 kg (6.6 lbs), bringing their total weight loss to a brilliant 43 kg (95 lbs).

Feel inspired by this impressive Mounjaro weight loss before and after success story? Request a consultation today. 

User 10: An Outstanding Start in 6 Months

• Starting Weight: 250 lbs (113.4 kg)
• Current Weight: 213 lbs (96.6 kg)
• Time Using Mounjaro: 6 months
• Dosage: Not specified
• Total Weight Loss: 37 lbs (17 kg)

Over 6 months on Mounjaro, this user lost 37 pounds (17 kg), going from 250 lbs (113.4 kg) to 213 lbs (96.6 kg). Before starting, they struggled with pain, mobility issues, IBS, and GERD. Now, they can move more easily, run up and down stairs, and experience significant improvements in their skin, mood, and overall health.

Mounjaro Before and After: 1 Month Snapshot

The above Mounjaro before and after pictures have certainly provided a snapshot into the impact the medication can have over a long period of time, but what can you expect in the short-term? Are you likely to notice any signs of weight loss? How much bodyweight might you be able to lose?

In this section, we’ll delve into what weight loss on Mounjaro could be like in one month. It’s important to note, however, that the following information covers a typical user’s experience, so yours may be different.

Week 1

Your first week on Mounjaro will typically be spent adjusting to your new lifestyle and routine. You’ll most likely begin on the lowest dose of 2.5 mg of tirzepatide and stay there for at least four weeks. This is to give your body the chance to adjust to the medication and reduce the potential impact of side effects.

Any weight loss achieved during this time will likely come from lost water weight and probably won’t amount to too much. This is perfectly normal, so there’s no need to worry about what the scales are saying right now.

What you should be able to notice instead is a reduction in appetite and food consumption. You might also feel fuller for longer and be less interested in snacking. All of this makes sticking to a calorie-controlled diet much easier. 

Week 2

The second dose of Mounjaro needs to be taken on the same day and time as your previous one, though ideally at a different injection site. Weight loss during this week is still not likely to be huge, as clinical trials have proven that people lose an average of less than 1% per week of their starting body weight in the early stages.

You may find that fatty and sugary foods become less attractive and portion control gets easier. As you start to eat less, you may also find that you’re drinking less water as well. Staying hydrated is crucial to dealing with side effects such as nausea and headaches, so make a conscious effort to keep drinking. 

Week 3

At this point in your Mounjaro journey, any weight lost should come from fat rather than just losing water — a clear sign that things are going in the right direction. Any side effects you’ve experienced up to now are likely to have eased significantly, making treatment much more manageable.

While the scales might not show much movement, you could start noticing other improvements, such as increased mobility or a change in how your clothes feel. Managing your appetite, portion sizes, and cravings should all have become much easier by now, too. 

Week 4

Congratulations, you’ve made it to one month on Mounjaro. The injection you administer this week may also be the last at the starting dose of 2.5 mg, provided you’ve been tolerating the medication well up to this point. If you feel that you need to stay at this strength for a bit longer, that’s completely fine. Remember that everything should be done at your own pace.

Typically, the first month of Mounjaro (or any other weight loss treatment for that matter) is the hardest, as you and your body get used to a major upheaval in routine. Having now made it through this formative phase, you should feel much more confident and ready to experience significant results.  

Mounjaro Before and After: First Month Results

After completing your first month on Mounjaro, you’re likely to have lost an average of 4% of your starting body weight. Your exact results will depend on a number of factors, such as how well you’re following your diet and exercise plan.

If you’d like to find out more information about what your first month on Mounjaro could look like, please check out our in-depth guide. 

Mounjaro 1 Month Tips

When starting out on your Mounjaro journey, things may seem daunting at first. However, getting in the right mindset and following these simple tricks should help make things easier.

• Set Realistic Goals: Avoid pressuring yourself to lose a significant amount of weight in a short period. Setting realistic goals will give you a better chance of making it through the early stages, when weight loss is typically minimal. 
• Play the Long Game: Losing weight on Mounjaro isn’t a quick fix; instead, it takes time and effort to achieve meaningful results. Be prepared to be in it for the long haul. 
• Establish Your Routine: Mounjaro works best when it is taken on the same day, at the same time. Creating a routine that suits your lifestyle at an early stage will enable you to stay on track and keep disruption to a minimum. Commit yourself to real change and reap the benefits. 
• Make the Change: Significant weight loss doesn’t just come from taking Mounjaro alone. It has to be done in conjunction with a healthy diet and regular exercise. 
• Go at Your Own Pace: Everyone’s weight loss journey is different. Don’t compare yourself to other people or clinical trial results. Trust in the process and you’ll get there. 
• Keep Moving Forward: Weight loss happens in stages. Sometimes you will experience a significant shift, while other times there may be a plateau. Whatever you’re going through, keep the faith with the process, and you will get there in the end.

Sticking to these tips and tricks should help you navigate through your first few weeks on Mounjaro and set you up for future success. 

Mounjaro Before and After: Beyond Month 1

It’s important to remember that Mounjaro is intended as a long-term weight loss solution, rather than a miracle cure. Results are meant to build up over time, meaning what you’ll lose after month three, for example, should be quite a bit more than during the first four weeks.

As you progress through the weeks and months of the Mounjaro dosage schedule, you’ll notice the amount of weight you lose will increase, but you’ll also notice positive changes in other areas of your life, too, including finding daily tasks easier, naturally choosing healthier foods, and a boost in confidence.

Mounjaro Before and After 3 Months Results 

At this stage in your treatment, if everything has gone to plan, you should be on the 10mg weekly Mounjaro dose. The average weight loss over 3 months in clinical trials at this point is around 8%, but don’t worry if you are below (or above) this amount, because your weight loss journey and how your body responds to tirzepatide are unique to you.

The significant weight loss to date will be due to the combination of Mounjaro and the formation of healthy lifestyle habits, such as eating the right foods, avoiding unhealthy foods, and exercising more regularly. Continuing these changes is key to your continued weight loss success.

Mounjaro Before and After 6 Months Results 

After 6 months on Mounjaro, clinical trials report an average weight loss of 12-15%. By this point, you should be on the highest Mounjaro dose, which has the greatest potential for weight loss.

After 36 weeks (9 months), further trials show that the average weight loss is almost 21% and that waist circumference is reduced by 4.3 cm. However, weight loss isn’t the only notable change after 6 months on Mounjaro. Users also report:

• Appetite reductions
• Reduced “food noise”
• Improved blood pressure
• Improved blood glucose levels

At this stage, Mounjaro’s effects will be well established, and you should be finding that following a diet and exercise plan is becoming easier.  

Mounjaro Before and After 1 Year & Beyond

So, what are your long-term weight loss prospects on Mounjaro? Well, aside from the aforementioned reliance on diet and exercise, another key factor is the maintenance dose you end up sticking to. Although the maximum dose is 15 mg of tirzepatide, you can actually stop titrating your dose at 5 mg and 10 mg as well. Exactly where you stop can depend on how well you’re coping with side effects and if you’re satisfied with your pace of weight loss thus far.

After 72 weeks of Mounjaro treatment, one clinical trial noted that the amount of weight lost on each maintenance dose was as follows:

• 16% of their starting body weight on 5 mg each week
• 21.4% of starting body weight when taking 10 mg per week
• 22.5% of their starting body weight on 15 mg each week

Almost all participants in the study experienced a weight loss of at least 5% of their starting weight, regardless of the dose they finished on.  

Mounjaro Before and After: Beyond Weight Loss

What life looks like after Mounjaro isn’t just about having a slimmer body. If you’ve established healthy habits, like a balanced diet and regular exercise, maintaining your results after stopping the medication will be easier. But many people find that the most valuable changes that have occurred extend beyond the number on the scale.

Enhanced Mobility

Weight loss reduces strain on your joints, lowers pain, and increases your energy levels, all of which improve your range of motion and mobility, making exercise easier and relieving chronic pain. Some research has shown that GLP-1 medications, like Wegovy and Mounjaro, can reduce pain in rheumatoid arthritis patients, improving their quality of life.

Increased Energy

With reduced weight, many Mounjaro users also report no longer feeling fatigued after daily activities or exercise. They note that they have increased stamina and find physical tasks, like climbing stairs, easier than before. 

Better Health

Mounjaro has many metabolic health benefits, and clinical trial data often demonstrate improvements in several markers, including blood sugar levels, blood pressure, and even belly fat. One study found that the average reduction in total body fat mass was 33.9% with tirzepatide, while another concluded that tirzepatide was linked to a lower risk of cardiovascular death.  

Increased Control

Mounjaro can give you the boost you need to better control your eating habits by regulating your appetite and blood sugar levels. For example, Mounjaro makes it easier to stick to a reduced-calorie diet and commit to regular exercise, helping you build more sustainable habits you can continue even after you stop taking Mounjaro. 

Boosted Confidence

By taking control of your health and adopting a healthier lifestyle, Mounjaro can boost your confidence, reduce anxiety, and improve mental clarity. 

Key Considerations 

Mounjaro will not work on its own. It works best with a commitment to making simple yet effective lifestyle choices to yield the best results. When you choose Mounjaro as your preferred weight loss treatment, there are several things you must consider. Understanding these factors is the key to your ongoing success.  

Some of the key considerations for taking Mounjaro are:

• Weight loss results will vary: Many of the reported losses in clinical trials are averages, so you may lose more or less weight. It just depends on how your body responds to the medication. You can enhance your progress by making positive lifestyle changes, being patient with yourself, and celebrating the small wins.
• Lifestyle changes are non-negotiable: That’s right, you will need to change your lifestyle by sticking to a diet plan and increasing your activity levels if you want Mounjaro to be successful. 
• It’s a long-term commitment: Weight loss doesn't happen overnight, and Mounjaro isn't a quick-fix solution. Many studies have lasted 72 to 104 weeks, so you must be prepared to stick with it for a long time. You will hit obstacles along the way, such as weight loss plateaus, which will require you to adapt your approach. 
• Cost: Mounjaro is not cheap, and you should prepare for the potential long-term costs to ensure it is affordable for you. There are alternatives available, and our clinician can help you switch from Mounjaro to Wegovy if that is a more viable option.
• Side effects are possible: The most common gastrointestinal side effects, like feeling or being sick, constipation, diarrhoea, and sulphur burps, are mild but can be unpleasant. They are most common when you first start treatment and when your Mounjaro dose increases, but there are things you can do to help manage them, like staying hydrated, getting rest, and eating smaller, more frequent meals. For most people, these side effects improve as their bodies get used to the medication. 

Essential Weight Loss Support from Prescription Doctor

These Mounjaro before and after success stories truly highlight the impressive weight loss transformations that are possible when taking the medication. However, it’s important to note that the treatment is not a miracle cure — you’ve got to be prepared to commit to lifestyle changes such as a healthy diet and regular exercise to reap the full benefits.

If all of this sounds daunting, the good news is that you don’t have to do it alone. Prescription Doctor is here to help. We offer a comprehensive weight loss consultation service that’s designed to support you every step of the way. From a smooth and straightforward consultation process to regularly checking in to monitor progress, we are here to help.

We stock the full range of Mounjaro doses – 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15mg – so you can start at the right level and adjust as needed over time. In addition, we offer a wealth of information about subjects such as how to use the Mounjaro Kwikpen, the side effects you may experience, and essential tips and tricks for success. Our clinicians are also on hand to assist with any queries you may have about treatment.

Ready to get started? Begin your Mounjaro consultation today. 

Authored & Reviewed By

Mohamed Imran Lakhi

MPharm - Lead Pharmacist

Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 07/02/2025 Re-Published on: 21/08/2025 Reviewed on: 21/08/2025