Ozempic has been hailed for its ability to make you feel full, reducing your calorie intake, and lowering your blood sugar levels. Collectively, these things can aid weight loss in type 2 diabetic patients. Here we’ll discuss how Ozempic works and decipher the science behind its effectiveness.
Ozempic contains semaglutide, the same active ingredient as the weight loss injection Wegovy. Because Ozempic isn’t licensed as a weight loss medication in the UK, so instead you’ll need to buy Wegovy.
Ozempic is a brand name for the active ingredient, semaglutide which belongs to a class of medications called glucagon-like peptide-1 (GLP-1) agonists, also known as incretin mimetics or GLP-1 receptor agonists.
There are several different GLP-1 agonists available in the UK for weight loss, such as Wegovy, Mounjaro, and Saxenda. Ozempic, on the other hand, is licensed to treat type 2 diabetes in the UK and not weight loss, although some private weight loss clinics may prescribe it ‘off-label’ – prescribing a medication for a different purpose than what it has been approved for.
Ozempic is licensed to treat type 2 diabetes in the UK, not for weight loss. Wegovy is an alternative to Ozempic for weight loss that’s available privately and on the NHS.
Ozempic can help manage blood sugar levels if you have type 2 diabetes. It is injected weekly and can be taken either on its own or with other diabetes medications, such as metformin.
Ozempic works in the same way as Wegovy, except the highest maintenance dose of Wegovy is higher than the Ozempic maintenance dose. That means Wegovy has better weight loss results than Ozempic.
Ozempic contains the active ingredient semaglutide which works by mimicking the effects of GLP-1, a hormone that’s naturally produced by your stomach when you eat. By doing so, semaglutide works to lower your appetite, slow down the time it takes for food to move through your digestive system, and stimulate the release of insulin.
Semaglutide acts like GLP-1 by binding to the receptors in the brain that regulate appetite, particularly after you have eaten. When bound to these receptors, your brain gets the message you are full, so you’ll stop eating. It can also activate nerve cells that reduce hunger and cravings while preventing the release of chemicals that make you want to eat. Because Wegovy also contains semaglutide, it also suppresses your appetite, reducing hunger, and causing you to eat less.
Alongside suppressing your appetite to stop you from consuming excess calories, semaglutide (Ozempic & Wegovy) also slows down digestion.
When food is digested and your stomach is empty, hormones are released that signal to the brain that you feel hungry, topping up your energy levels. It usually takes around 4 hours for your stomach to empty fully after a meal, but semaglutide can slow gastric emptying down, so you feel fuller for longer.
When you eat, the body breaks down food into glucose or sugar. To help your cells absorb the sugar from the blood and use it for energy, the pancreas releases insulin. When the body’s energy demands are met, insulin levels increase to deal with the rapid rise in blood sugar, signalling to the brain that we’re full.
Semaglutide mimics this signal as blood sugar levels rise, so that your pancreas releases insulin in response. This not only aids with weight loss because it can reduce the amount you eat, but it also helps to manage type 2 diabetes, which is what Ozempic is licensed for in the UK.
The active ingredient in Ozempic, semaglutide, can help you lose weight, however, Wegovy is more effective and available as a weight-loss injection. Studies show that Wegovy can help you lose 15% of your body weight at the maximum dose over 68 weeks.
No, Ozempic is not licensed for use as a weight loss injection in the UK. Instead, Wegovy is available for weight loss in the UK. Like Ozempic, Wegovy contains the active ingredient, semaglutide, at a slightly higher dose, so is approved for effective weight loss.
You can buy Wegovy online from Prescription Doctor following a short online health consultation with one of our clinicians. Once they have approved that Wegovy is safe and suitable for you, we can send your order for next-day delivery, If your order is approved by 3 pm.
Ozempic is a once-weekly injection that’s approved for treating type 2 diabetes in the UK. It contains the same active ingredient as the weight loss injection, Wegovy, called semaglutide.
Semaglutide mimics the effects of GLP-1, a digestive hormone that signals to the brain when you feel full, slows down digestion and lowers your blood sugar levels. If you are interested in Ozempic for weight loss, you’ll need to consider its alternative, Wegovy.
Sources
BMJ, 2023. Appetite-suppressant semaglutide is to be made available to treat obesity in England.
Diabetes, Obesity & Metabolism, 2022. Semaglutide delays 4-hour gastric emptying in women with polycystic ovary syndrome and obesity.
emc, 2024. Wegovy 2.4 mg, FlexTouch solution for injection in pre-filled pen.
MHRA, 2014. Off-label or unlicensed use of medicines: prescribers’ responsibilities.
NICE, 2024. Diabetes - Type 2: What is it?
Springer Nature, 2021. Weight Loss and Maintenance Related to the Mechanism of Action of Glucagon-Like Peptide 1 Receptor Agonists.
The Royal Society, 2006. Pancreatic signals control food intake; insulin, glucagon and amylin.
Additional Resources
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