Wegovy Weight Loss: Week by Week Guide

Choosing the right medication to support you on your weight loss journey is key to you achieving your goals, and Wegovy is one of the options available to you. When making this important decision, understanding how much weight you can lose on Wegovy is likely to be one of the major contributing factors.

The medication works by mimicking a naturally produced digestive hormone, glucagon-like peptide-1 (GLP-1), to help keep you feeling fuller for longer after a meal, thereby slowing down digestion and aiding in weight loss. It is designed for gradual progress and requires sustained, consistent effort to achieve significant changes in your body composition.

So, how does Wegovy weight loss look week by week? Join us as we delve into clinical trial results and outline the results you could achieve in your first three months of treatment and beyond. 

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How Much Weight Can I Expect to Lose on Wegovy Overall?

Wegovy is a potent and popular weight loss injection that can help you lose up to 15% of your starting body weight after 68 weeks on the maximum maintenance dose. Research also shows that Wegovy helps 86% of users shift at least 5% of their body mass in this time. These results are impressive, but everyone’s journey is different.

Your own Wegovy weight loss results will be unique to you and will be determined by several factors, including your age, starting body mass index (BMI), lifestyle changes, and how well your body responds to semaglutide.

Using the latest research, we explore the average Wegovy weight loss week by week to give you a greater understanding of what this GLP-1 agonist can help you achieve and what you can expect in the first 12 weeks of treatment.

Wegovy Weight Loss Timeline: What You Should Expect

Wegovy takes effect after your first injection, with some people noticing changes in appetite and overall well-being within a few days. Provided you adhere to your treatment schedule as closely as possible and incorporate healthy habits into your lifestyle (such as a balanced diet and regular exercise), sustained weight loss should be within reach.

To help you along your way, you should, after a while, begin to spot various signs of weight loss. These can include your clothes becoming baggy and an overall change in appearance. Little things like this can be great for motivation, as you will clearly see that all your hard work is paying off.

Now that we’ve established the basics, let’s examine Wegovy weight loss on a week-by-week basis. 

Wegovy Week 1 Results

Week one of your Wegovy weight loss journey will involve injecting your first of four weekly doses of 0.25 mg of semaglutide. This is a good opportunity for you to monitor how well your body tolerates the medication by looking out for any Wegovy side effects, such as nausea, diarrhoea, constipation, or headaches.

At this point, it is good practice to establish a routine for injecting Wegovy. Choose a day and time that suits you because this will remain the same throughout your treatment. You can inject Wegovy at any time of the day, so long as you are consistent. Some people prefer to take it first thing in the morning, while others opt for just before bed, particularly if they experience side effects. However, the choice is yours.

This may also be the first week that you start implementing the lifestyle changes that will support you in achieving your weight loss goals. It’s a good time to start putting together a diet plan that includes the foods you can eat and identifying those that you should avoid or limit. Our clinicians can help you if you are struggling with lifestyle changes or need additional support with nutrition or exercise.

It’s unlikely that you will notice much weight loss at this stage, but don’t be disheartened; this is just the beginning. Focus on the positives that you are taking steps to improve your lifestyle and lose weight – a positive mindset will do wonders for your progress. 

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Wegovy Week 2 Results

During week two, it is essential to continue monitoring any side effects you experience and report them to your clinician if they are severe or if you are concerned. Most Wegovy side effects are mild and temporary, and can be managed at home in the following ways:

• Headaches: Drink plenty of fluids and take over-the-counter painkillers, such as paracetamol or ibuprofen. 
• Feeling or being sick or diarrhoea: Eat smaller, more frequent meals, avoiding spicy, greasy, and fatty foods. Stay hydrated by drinking plenty of clear fluids and resting until you feel better.
• Constipation: Try increasing the amount of fibre in your diet and drinking more water to help make it easier to pass stools. Engaging in gentle exercise, such as going for a walk, can also help manage uncomfortable symptoms, including bloating.
• Indigestion or acid reflux: Your clinician or a pharmacist can recommend over-the-counter remedies, such as antacids, to help manage these side effects.
• Injection site reactions: If you experience sores or irritation at the injection site, it is essential to rotate the injection site weekly. Discover more in our expert guide.

Although any significant weight loss is still unlikely, you may start to notice changes in your appetite. For example, you might feel less hungry or crave less. These are positive signs that Wegovy is working. 

Wegovy Week 3 Results

By week three, the levels of semaglutide in your body become more stable, allowing for a more consistent feeling of fullness. You may even notice that you have lost a few pounds by now, even if you cannot physically see any changes in your weight.

At this point, it’s a really good idea to keep going with your lifestyle changes. Don’t be too hard on yourself if you find them challenging, as it can take 66 days for a lifestyle change to become a healthy habit, but doing it daily will make it easier.  

To help boost your progress, try focusing on small but effective changes, such as increasing your protein intake, exercising regularly, getting sufficient sleep, and managing stress effectively. These strategies can support your results while taking Wegovy. You can enhance your progress with our 5 ways to increase weight loss with Wegovy guide.

Wegovy Week 4 Results

You’ve completed your first month of Wegovy treatment, and it’s time to celebrate. According to research, it’s possible to lose around 2% of your initial body weight in four weeks. However, everyone’s journey is different and tracking your weight isn’t the only way to measure success in the early stages of Wegovy treatment.  

So, rather than focusing on the number on the scales, focus on the small wins, like the fact you’re changing your diet and choosing healthier options or that you’ve stuck to four weeks of increased physical activity.  

Wegovy Month 2 (Weeks 5-8)

If you are comfortable managing the initial strength, your clinician will likely recommend titrating the Wegovy dosage schedule to 0.5 mg per week for the next four weeks. As you increase the strength, you may notice your side effects temporarily return or worsen.

By week 8, the average weight loss with Wegovy is approximately 4%, equivalent to 1% every two weeks. Therefore, it is essential to stay on top of your diet and exercise plan to further enhance your progress.  

Wegovy Month 3 Results (Weeks 9-12)

If you are tolerating Wegovy well, the start of month three should see your dose increase to 1mg per week, which should be accompanied by more significant and noticeable weight loss. You could be on track to lose an average of 6% of your initial body weight by week 12.

A reduction in body mass isn’t the only change you should feel at this point in our journey. Look out for the following signs, which can reiterate the positive steps you are taking to change your life and to reinforce the powerful benefits of Wegovy:

• increased energy levels
• improved sleep
• better mood
• enhanced movement and fitness

Wegovy Weight Loss: Week 13 and Beyond

At this stage, you’re fast approaching the full dose of Wegovy, but for the next four weeks, you’ll inject 1.7mg of semaglutide. If this works well for you, you can choose to stick to this as your maintenance dose or titrate up to the maximum strength of 2.4mg at week 17.

Research shows that by week 16, the average weight loss is approximately 8%, and you may notice improvements in your blood pressure and blood sugar levels. If you are experiencing any prolonged or concerning side effects, it is important to discuss them with your clinician before titrating up any further.

At the highest maintenance dose of Wegovy, it is possible to lose up to 15% of your starting weight after 68 weeks of treatment. That’s why it's vital to continue with the lifestyle modifications you've made to support your ongoing progress.

Part “a” of the graph shows the change in body weight (y-axis) over time (x-axis) for individuals who received either Wegovy (semaglutide) (blue line) or placebo (grey line). Part “b” shows the percentage of participants who had a better than 5% improvement with Wegovy (semaglutide) (blue bar) or placebo (grey bar). Data from the STEP5 Clinical Trial.

How to Lose More Weight on Wegovy

Wegovy is a long-term medication which is intended to support gradual, consistent, and safe weight loss. It’s also important to note that the active ingredient, semaglutide, will not work on its own and requires a sustained effort to change your lifestyle, particularly with regard to your diet and activity levels.

Thankfully, there are several ways to lose more weight on Wegovy, including:

• Follow a healthy, balanced diet
• Be more active
• Manage stress and practice good sleep hygiene
• Make sure you’re on the right dose
• Monitor your progress

If you’ve done all of these things and you’re not getting the desired effects, here are 5 reasons why you aren’t losing weight on Wegovy. It's possible that Wegovy isn’t the right weight loss medication for you, and an alternative, such as Mounjaro or Nevolat, may be more effective. 

Wegovy

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• Approved Weight Loss treatment
• Weekly injection
• Reduces risk of heart attack & stroke

• Discreet delivery next working day
• Online prescription - No doctor visit

Prices from £139.99 Review More Prices

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Wegovy Weight Loss FAQs

Whether you’re considering which weight loss medication is best for you or you’re already a few weeks into your Wegovy journey, it’s natural to have questions about Wegovy weight loss and how much weight you can expect to lose week by week. Here, we answer some common Wegovy FAQs to help you make a more informed decision. 

Does Wegovy Interfere with Other Medications?

Yes, Wegovy can interact with certain medications, which is why it is essential to inform your clinician about any other treatments you may be taking. One example is that Wegovy can lower blood sugar levels, meaning using it in conjunction with other medications that decrease glucose could lead to hypoglycaemia.

Because semaglutide slows down gastric emptying, it can affect the absorption of oral medications. This is important to note if you’re taking the contraceptive pill, as you may need to use a barrier method, like condoms, to prevent pregnancy. Wegovy side effects, such as vomiting or diarrhoea, can also impact absorption, so it’s essential to monitor this and contact your clinician if you think your treatment isn’t working as it should.

When discussing the medication you’re taking, be as thorough as possible. This means including everything you’ve been prescribed, bought over the counter, and even herbal remedies.

Do You Lose More Weight on a Higher Dose of Wegovy?

Yes, the average Wegovy weight loss of 15% is achieved with the highest weekly dose of 2.4 mg. However, it is still possible to lose weight on the lower strengths, with an average weight loss of 2% after four weeks. Nevertheless, if you don’t reach the higher doses, you are unlikely to achieve the optimal benefits.

Your clinician will monitor your progress and how well your body responds to Wegovy as you titrate up the dosage schedule. 

How Long Should You Take Wegovy?

Wegovy has been approved for long-term use to treat obese and overweight adults. Your clinician will monitor your progress, but it can be taken for as long as it remains beneficial for weight loss and isn’t causing you any severe or unmanageable side effects. 

How Long Before Wegovy Side Effects Start?

Wegovy side effects can affect anyone who takes the medication, although not everyone will get them. In most cases, side effects will occur within the first few weeks of treatment, are often mild, and should get better on their own. They may also return when your dose increases.

If you get side effects that you are struggling to manage or that are affecting your daily life, you may need to consider an alternative weight loss medication. At Prescription Doctor, our clinician can help you switch from Wegovy to Mounjaro, Nevolat, or any other available treatment if appropriate. 

Essential Support with Wegovy Weight Loss

If you’re ready to take the next step on your Wegovy weight loss journey, you need a supportive partner to guide you along the way. That’s where the Prescription Doctor comes in. Since 2013, we’ve been supporting people like you to transform their lives. Our pharmacy is registered with the General Pharmaceutical Council (GPhC), ensuring you receive the highest possible standards of care.

Our clinicians can provide you with tailored weight loss advice, including a 7-day diet plan (alongside vegan options), guidance on how to inject Wegovy, or help you choose the most suitable medication based on your individual circumstances. Because weight loss is a highly personal experience, we also ensure that your injection pens are delivered discreetly in plain packaging, protecting your privacy. Additionally, orders approved before 3pm on a weekday are available for next-day delivery.

Our service doesn’t just stop there, however, as we’re here to support you throughout your entire journey. Our clinicians will regularly check in with you to monitor progress and ensure everything is working as smoothly as possible.

Are you ready to become the next Wegovy success story? Start your weight loss consultation with Prescription Doctor today. 

Authored By

Leanne Edermaniger

Medical Content Writer

Leanne is a science and health content writer focusing on human health and biology while utilising her solid academic background.

Published on: 31/05/2024 Re-Published on: 25/07/2025

Reviewed By

Mohamed Imran Lakhi

MPharm - Lead Pharmacist

Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Reviewed on: 25/07/2025