Differin (Adapalene)

What is Differin?

Differin is a topical retinoid treatment for acne, available as either a gel or a cream. Both contain the same active ingredient, adapalene 0.1%, and work in the same way. Differin gel is a smooth, opaque white gel, best suited for people with more oily skin. Differin cream is a glossy white cream better suited for individuals with drier skin. Ultimately, your choice of gel vs. cream comes down to personal preference.

The medication is licensed in the UK for mild-to-moderate acne and is classified as a prescription-only medicine, so it can't be bought over the counter.

Understanding Acne

Most people deal with acne at some point during their lives. It's the most common skin condition in the UK, and while it often starts during the teenage years, it doesn't always stop there – it's thought to affect around 12% of adult women and 3% of adult men over 25.

At its core, acne is a blocked-pore problem. Dead skin cells and a protein called keratin clump together inside the pore, trapping sebum – the oily substance your skin naturally produces. A bacterium called Cutibacterium acnes (C. acnes) thrives on this trapped sebum. As it multiplies, it releases irritants that trigger redness, swelling, and the spots you see on the surface.

Androgens, particularly testosterone, drive sebum production, which explains why breakouts spike during puberty and, for women, can worsen around certain points in the menstrual cycle, in early pregnancy, or with conditions like PCOS. Genetics, certain cosmetics, some medications, and smoking can all play a part, too.

How Does Differin Work for Acne?

Adapalene belongs to a class of medicines called retinoids. It tackles acne in two key ways:

• Keeping pores clear: Adapalene influences how skin cells mature and shed inside the follicle, stopping them from clumping together and forming blockages. This comedolytic (the breakdown of whiteheads and blackheads) action addresses the root cause of how spots form rather than just treating them once they've appeared.
• Calming inflammation: It also has a direct anti-inflammatory effect, reducing the redness and soreness associated with inflamed breakouts.

One thing Differin doesn't do is reduce oil production itself. It works by keeping pores open and reducing irritation, so sebum can flow freely rather than get trapped.

Where Does Differin Fit in Acne Treatment?

A fixed-dose combination of adapalene and benzoyl peroxide (such as Epiduo) is among the first-recommended options for acne of any severity. Importantly, when using Differin alongside another suitable acne treatment product, apply the other products in the morning and Differin at night.

Once your skin has cleared after a full treatment course, adapalene on its own (i.e., Differin) may be considered a maintenance option to help prevent breakouts from returning. This tends to suit situations where ongoing treatment is appropriate, but a combination product isn't the right fit.

Your prescriber can advise on whether Differin alone or another option works better for your situation.

How Long Does Differin Take to Work?

Patience is important. Differin needs around 12 weeks of consistent use before you can properly judge how well it's working. Your prescriber should review your progress at the three-month mark. If your acne hasn't improved after 3 months, or gets worse at any point during treatment, seek advice from your prescriber.

How Effective is Differin for Acne?

Numerous high-quality clinical studies have researched the safety and efficacy of adapalene. As such, it is a trusted first-line treatment option for individuals struggling with acne.

A meta-analysis (a review of multiple independent studies) of 5 large studies with over 900 patients over 12 weeks showed that adapalene 0.1% gel was as effective as tretinoin (another well-established acne treatment), with adapalene having a faster onset of action and less frequently reported irritation.

Studies have also confirmed adapalene's usefulness as a maintenance therapy to control acne after the initial treatment phase. One study of 253 patients showed ongoing clinical benefit with continued treatment compared with vehicle (the same gel, but without the active medication).

Other studies have confirmed that using adapalene alongside benzoyl peroxide (a common combination acne treatment regimen) is safe, well tolerated, and effective.

Overall, clinical evidence supports adapalene as a strong first-line treatment option for active flare-ups and maintenance therapy.

How to Use Differin Adapalene Gel

Use Differin once a day before bed (unless your prescriber advises otherwise). More information is available in the Patient Information Leaflet that comes with the medication. You should follow these steps when applying adapalene gel or cream:

1. Wash the area you're treating with a mild, non-irritating cleanser and warm water. Pat your skin completely dry.
2. Squeeze a thin film of the gel or cream onto your fingertips and spread a thin, even layer across the affected area. Rub it in gently.
3. Wash your hands when you're done.

Wait until Differin has been absorbed before applying moisturiser or cosmetics (check with your prescriber which products are suitable and when to apply them). Stick to non-comedogenic products that won't clog pores or over-dry your skin.

Keep Differin away from your eyes, lips, nostrils, and any other sensitive areas. If it gets somewhere it shouldn't, rinse it off right away with warm water. Don't use it on broken skin, sunburnt areas, or eczema-affected skin. Differin isn't intended for large areas of severe acne. If you use too much, wipe off the excess with a tissue.

Discuss your acne treatment progress with your doctor after 3 months. They may suggest continued maintenance treatment or a change in your medication.

Combining Differin with Other Acne Products

You can safely use Differin alongside topical treatments containing benzoyl peroxide, erythromycin, or clindamycin. Use these products in the morning and Differin at night. Always check with your prescriber before using Differin with another acne treatment, skincare product, or cosmetic item.

Don't use Differin with other retinoid products, whether topical or oral. Doubling up on retinoids can cause irritation and other side effects.

Protecting Your Skin from the Sun

Adapalene can make your skin more sensitive to sunlight and UV light. While you're using Differin:

• Minimise sun exposure and avoid sunbeds
• Apply a broad-spectrum sunscreen (SPF 30 or higher) every day
• Wear protective clothing when you're spending time outdoors

This applies year-round, not just in summer. If you still experience sunlight sensitivity whilst using this product, speak to your clinician.

If You Forget to Use Differin

Don't worry if you forget to use Differin gel or cream at the right time. Restart your treatment the next time you remember. You should still try to use Differin before bed, and do not use it at the same time as other acne treatment products in the morning.

You may notice your acne worsens if you regularly miss doses.

If You Use Too Much Differin

Using more Differin than you should will not clear your acne any quicker, but your skin may become irritated and red. You may also experience peeling and discomfort. If you accidentally squeeze too much cream or gel out of the tube, wipe off the excess and wash your hands.

Differin Side Effects and Cautions

Clinical studies show that Differin is usually well tolerated. However, like any medication, side effects have been reported in some people who use it. Review the following safety information to ensure that Differin is right for you.

Differin Cream and Differin Gel Side Effects

Side effects from Differin use usually occur at the application site. This is because very little of the medication is absorbed systemically into the rest of the body. A detailed breakdown of Differin Gel and Differin Cream side effects is available in the Patient Information Leaflet that comes with the medication.

If you experience side effects from Differin use, speak to your doctor or pharmacist. You can also report side effects using the MHRA's Yellow Card Scheme.

Serious Differin Side Effects

Stop using Differin and seek medical help straight away if you develop any of the following:

• Swelling of the face, lips, tongue, or throat
• Difficulty breathing or swallowing
• A widespread rash, hives, or intense itching
• Dizziness or feeling faint

These can be signs of a serious allergic reaction (angioedema or anaphylaxis) and need urgent attention.

Application site burns have also been reported. These were mostly superficial, but second-degree or severe burns have also been reported. If this occurs, wash your face with water repeatedly and seek medical assistance.

Differin Warnings and Interactions

Although Differin gel and cream are effective treatments for acne, they are not suitable for everyone. You should not use the medication if you:

• Are allergic to adapalene or any of the other ingredients listed in the medication
• Are pregnant or planning to become pregnant

If you are unsure whether Differin is right for you, speak to your prescriber.

Precautions for Using Differin

Before using Differin cream or gel for the first time, review the following safety advice:

• Do not use Differin on skin with cuts, scrapes, sunburn, or that is affected by eczema
• Avoid contact with eyes, mouth, angles of the nose, or other sensitive areas of the body. If contact occurs, wash immediately with warm water
• Avoid exposure to strong sunlight and UV light
• If you experience sensitivity or irritation, stop using Differin and tell your prescriber. They may recommend stopping treatment or using the product less often once symptoms have subsided
• Differin is for external use only

Differin and Other Medicines

Tell your prescriber if you are taking or have recently taken any other prescribed medicines, over-the-counter medications, herbal remedies, or supplements. If you use other acne treatments, check with your prescriber to make sure they're suitable. Use these products in the morning, while applying Differin before bed. You must not use another retinoid product (cream or oral) whilst using Differin. You may use cosmetics alongside Differin treatment, but they must not cause blackheads or dry skin.

Pregnancy and Breastfeeding

Don't use Differin if you're pregnant or planning to become pregnant. If you find out you're pregnant while using Differin, stop straight away and speak to your doctor.

Use Differin with caution while breastfeeding. Avoid applying it to your chest to prevent direct skin contact with your child. If you're unsure, speak to your prescriber.

Where Can You Buy Differin Gel and Cream

You can buy Differin only from licensed pharmacies and online pharmacy providers. It is a prescription medication, meaning your symptoms and medical history will have to be reviewed by an appropriately trained prescriber before you can buy it. At Prescription Doctor, our expert clinicians will review your confidential online consultation to determine whether Differin is right for you.

When buying medication online, it's essential to choose a reputable pharmacy you can trust. The General Pharmaceutical Council keeps an up-to-date register of licensed pharmacies.

Can You Buy Differin Over the Counter?

You cannot purchase Differin cream or Differin gel over the counter. In the UK, Differin is classified as a prescription-only medication (POM). As such, a trained prescriber must review your symptoms and medical history. This ensures it is the right treatment option to effectively meet your needs.

Is Differin Available on the NHS?

Adapalene is available on the NHS. When seeing an NHS GP, you may be prescribed Differin or a generic brand alternative containing the same active medication. In England, the standard prescription charge applies to all NHS prescriptions unless you have a valid exemption or pay via a prepayment scheme.

Can You Buy Differin Online?

Yes, you can buy Differin cream and gel online from trusted pharmacies such as Prescription Doctor. We've made it our mission to simplify the process of getting the medication you require, so you can order your treatment anytime from home. There's no need for an appointment, just a brief questionnaire so our experienced clinicians can determine whether the treatment is suitable for your circumstances.

Once approved, your order will be dispatched from our General Pharmaceutical Council-registered pharmacy in plain packaging for complete discretion. Orders approved before 3pm on a weekday are also eligible for next-day delivery to your designated UK address.

Frequently Asked Questions About Differin