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Epiduo
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Treatment Information
![Mohamed Imran Lakhi]()
Table of contents
- What is Epiduo?
- What causes acne?
- How does Epiduo work for acne?
- How do I use Epiduo Gel?
- Epiduo side effects and cautions
- Frequently asked questions
Ordering Epiduo online for acne
You can request Epiduo Gel acne treatment online from our UK-registered online pharmacy and prescriber service. After completing your online consultation, one of our UK-registered prescribers will review your order. If approved by 3 pm, our pharmacy team will dispense and dispatch your medication to your chosen address.
What is Epiduo?
Epiduo is a topical acne treatment which contains a chemical compound (retinoid) called adapalene and benzoyl peroxide, known as the active ingredients.
The treatment is available as an off-white opaque gel. Epiduo only needs to be applied to the skin once a day.
How does Epiduo work for acne?
Epiduo combines both a retinoid and a peeling agent, which work together to clear acne.
The retinoid (adapalene) unblocks the pores to prevent acne from forming under the skin, reducing redness and inflammation of the affected area.
Benzoyl peroxide (keratolytic peeling agent) has antimicrobial properties which kill bacteria under the acne spots. It also helps to remove dead skin cells, keratin and sebum from the skin.
When used consistently, Epiduo is an effective acne treatment suitable for people who have tried adapalene and benzoyl peroxide agents on their own but have not had good results.
How do I use Epiduo Gel?
Epiduo is applied topically to the affected areas once a day, typically at night before bed.
Use the treatment regularly at the same time each day for the best results. Using more Epiduo will not improve your acne any faster.
Before you apply Epiduo, wash the affected areas of the skin with warm water and mild soap. Pat the skin dry before applying the treatment.
Using only a pea-sized amount, apply a thin layer of Epiduo gel to the affected areas of the skin once a day.
Always wash your hands after applying the treatment.
If you accidentally apply too much of the gel, wipe away the excess with a clean tissue and discard it safely.
Please understand that using more Epiduo than prescribed by your doctor will not clear your acne faster, but it may increase your risk of experiencing side effects.
Do not apply Epiduo to broken skin.
Take care when applying Epiduo to areas around the eyes, nose and mouth. If you get some Epiduo in your eyes, rinse your eyes with water. If you experience irritation long after rinsing it, contact your doctor immediately.
Epiduo comes in a tube with a screw-on top. Roll the tube from the bottom rather than squeezing it from the side to prevent the gel from getting trapped in the tube as you use Epiduo.
If you are unsure how to use Epiduo, ask a doctor or pharmacist for advice.
Alternatives to Epiduo Gel
The following alternative treatments are available from Prescription Doctor:
- Differin Gel (Adapalene)
- Duac Gel (Topical antibiotic & benzoyl peroxide)
- Lymecycline (Oral antibiotic)
- Zineryt (Topical antibiotic)
- Acnecide (Benzoyl peroxide)
Epiduo side effects and cautions
All medications carry risks of side effects, though not everybody experiences them.
Read the patient information leaflet for Epiduo for information regarding the product's usage and safety.
During the first week of treatment, your risk of side effects increases as your skin adjusts to the medication.
Before taking your first dose, you may wish to perform a patch test. Clean an area of your skin with warm soapy water and pat dry. Apply a small amount to clear skin, and leave for 24 hours. If you experience an allergic reaction, consult your doctor immediately.
Side effects of Epiduo
Common side effects (may affect up to 1 in 10 people) of using Epiduo include:
- Dry skin
- Local skin rash
- Burning sensation
- Irritation of the skin
- Redness
- Scaling
Uncommon side effects (may affect up to 1 in 100 people) of using Epiduo include:
- Itching of the skin (pruritus)
- Sunburn
This is not an exhaustive list of side effects. Further information regarding the safety of Epiduo, including a complete list of side effects, can be found within the patient information leaflet enclosed with your medication.
If you experience any side effects, whether listed above or in the patient information leaflet, report them to your doctor, ask a pharmacist or dial NHS 111 for advice.
Allergies
Do not use Epiduo if you're allergic to adapalene, benzoyl peroxide, or other ingredients listed in the patient information leaflet.
If you experience the signs and symptoms of an allergic reaction, stop using Epiduo and inform your doctor immediately. For severe allergic reactions such as suspected anaphylaxis, go straight to your nearest accident and emergency department. Remember to take the packaging and any remaining medication with you so that the doctors know what you have taken.
Signs of an allergic reaction include:
- Chest tightening
- Dry, red and cracked skin
- Itchy, red, watery eyes
- Raised, itchy, red rash (hives)
- Swelling of the lips, tongue, eyes or face
- Tummy pain, nausea, vomiting or diarrhoea
- Wheezing
Pregnancy and breastfeeding
Do not use Epiduo if you are pregnant, think you might be pregnant or plan on becoming pregnant. Speak to your doctor for further advice.
If you become pregnant while using Epiduo, inform your doctor as soon as possible.
Epiduo can be used by breastfeeding women, though you should avoid your child coming into contact with the treatment. For this reason, breastfeeding mothers should not apply Epiduo to their chests.
For more about the safety of Epiduo during pregnancy or while breastfeeding, speak to your doctor or pharmacist.
Epiduo clinical trial
Galderma Laboratorium GmbH, the manufactures of Epiduo, carried out a study to assess the long-term efficacy and safety of Epiduo (alone or in combination with other drugs) under daily clinical practice conditions in patients with moderate to severe inflammatory acne. Find out more about the study at clinicaltrials.gov.
Frequently asked questions
What should I do if I forget to use Epiduo?
If you forget to use Epiduo gel when you should, use it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and take the next dose at the usual time.
Do not use more Epiduo gel to make up for the missed application.
Will Epiduo affect my ability to drive or operate machinery?
Epiduo should not impact your ability to drive or operate machinery.
Can I drink alcohol while using Epiduo Gel?
Yes, you can drink alcohol in moderation while using Epiduo gel. Always adhere to the recommended limit of 14 units of alcohol per week.
Will Epiduo Gel affect my contraceptive pill?
Epiduo gel should not impact your contraceptive pill. For further information about using Epiduo while taking other medicines, speak to your doctor or a pharmacist.
Can I use a moisturiser with Epiduo Gel?
You can use Moisturisers while using Epiduo. Wait for the area of the skin to dry before applying a moisturiser.
Can I apply makeup while using Epiduo?
Before applying makeup, ensure the treated area is dry. If you apply makeup in the morning, use Epiduo before bedtime. Avoid makeup which dehydrates your skin or clogs your pores.
Can I use other acne treatments with Epiduo gel?
Do not use other products which contain adapalene or benzoyl peroxide while using Epiduo. Avoid using peels which contain salicylic acid or glycolic acid while using Epiduo gel, as this can cause further irritation or adverse effects. Before using any other acne treatment with Epiduo gel, speak to your doctor.
Additional resources
Natural ways to control your acne.
Control your hormones, control your acne
References
NHS, 2019. Acne: Overview, causes, diagnosis, treatment, complications.
British Association of Dermatologists (BAD), 2020. Acne.
Galderma, 2020. Epiduo 0.1%/2.5% Gel: Summary of Product Characteristics
Authored & Reviewed By
Mohamed Imran Lakhi
MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.
Published on: 11/09/2018 Reviewed on: 26/10/2023
Published on: 11/09/2018 Reviewed on: 26/10/2023
Treatment information
- Product Name: Epiduo
- Active Ingredient(s): Adapalene and Benzoyl Peroxide
- Manufacturer: Galderma
- Administration: Apply to affected area
- Presentation: Gel
- Available Strength: 45g Adapalene (0.1%) and Benzoyl Peroxide (2.5%)
- Exemption: Prescription Only Medicine
- Application: Men and women over 18 with acne
- Dosage: Apply once daily to affected area
- Description: Topical treatment for acne
- Drug Class: Retinoid
- Alcohol Consumption: Avoid excessive alcohol consumption
- When Pregnant: Do not use when pregnant. Speak to your doctor for more advice.
- When Breastfeeding: Safe to use when breastfeeding. Do not apply to chest area. Speak to your doctor for more advice.
- Price: 29.99 GBP
Click here to view the Epiduo - Patient Information Leaflet
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