Skinoren Cream

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  2. Fill in our short consultation form.
  3. Choose delivery method and mode of payment.
  4. Our team of expert prescribers will assess whether medication is suitable.
  5. If you get the green light and it is deemed suitable, your order will be processed quickly and efficiently.
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Delivery and Packing
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We deliver medications between Monday and Saturday. You can upgrade to Saturday delivery on Friday.

My Order Hasn’t Arrived What Should I Do?

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You can pay for your order using credit, debit card and bank transfer.

Card Payment: Please notify us that you wish to cancel your order. Your refund will show available In 1 - 3 days.

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Treatment Information

Table of contents:

Skinoren Cream Uses: What is Skinoren Cream Used For?

Skinoren is a skin cream used to treat common acne (acne vulgaris). It's not suitable for any other skin condition, meaning it is not a general-purpose skincare product. This is important because people sometimes look for Skinoren cream for pigmentation.

The reason for this is that azelaic acid (Skinoren's active ingredient) blocks tyrosinase, an enzyme involved in producing melanin, and it acts mainly on overactive pigment cells rather than normal ones. As a result, azelaic acid is used in other settings for conditions like melasma and post-inflammatory hyperpigmentation, which is the darkening that can linger after a spot has healed.

It's also worth noting that skin discolouration is a common side effect of Skinoren 20% cream, whereas loss of skin colour is uncommon, so azelaic acid can affect pigmentation in unwanted ways, too. If pigmentation is your main concern, speak to your prescriber or GP about treatments designed to address it.

How Does Skinoren Cream Work?

Acne develops when dead skin cells and excess oil block your hair follicles. Bacteria feed on the trapped oil and multiply, causing the inflammation behind red, sore spots.

Skinoren azelaic acid tackles this from two directions:

  • Targets Bacteria: Azelaic acid attacks Cutibacterium acnes (formerly known as Propionibacterium acnes), which plays an essential part in causing acne.
  • Helps Unblock Pores: Reduces the growth of the harder outermost skin cells that block your pores and cause blackheads and whiteheads.

One useful characteristic of azelaic acid is that bacteria don't develop resistance to it the way they can with antibiotics, which makes it a sensible option for longer courses of treatment.

How Long Does Skinoren Cream Take to Work?

You should see a distinct improvement after about 4 weeks of regular use. That said, how long you need to use Skinoren varies from person to person and depends on how severe your acne was when you started.

To get the best effect, you'll probably need to use it regularly for several months. The important thing is consistency. Applying it as directed every day is what makes the difference.

If your acne hasn't improved at all after a couple of months, or it gets worse, speak to your prescriber so they can review your treatment.

Skinoren Cream Results

Azelaic acid has been studied extensively as an acne treatment, and it holds up well against the better-known alternatives. For example, a single-blind study comparing 20% azelaic acid cream against 5% benzoyl peroxide gel found azelaic acid to be an effective treatment for papulopustular acne, with very good local tolerance.

Meanwhile, a comprehensive review found that across studies, 15–20% azelaic acid formulations produced clinically meaningful improvements. Reductions in both inflamed and non-inflamed spots were comparable to topical retinoids, and tolerability was better in some situations.

Finally, a combination therapy study showed that azelaic acid works well alongside other topical treatments. Its effect on inflamed spots improved further when combined with benzoyl peroxide, clindamycin, or tretinoin.

It's important to remember that everyone's skin responds differently. Skinoren works best applied consistently over several months rather than expecting rapid results.

How to Use Skinoren Cream

To apply Skinoren cream, follow these steps:

  • Thoroughly wash the whole area you're treating with plain water. If your skin is greasy, use a mild skin cleanser.
  • Dry the affected area thoroughly before applying the cream.
  • Apply a thin layer of Skinoren cream to the affected area. As a guide, if your whole face is affected, use about 2.5cm (roughly 0.5g) of cream each time.
  • Rub the cream in gently until it is evenly distributed.
  • Wash your hands thoroughly to remove any excess cream.

You should apply Skinoren cream once or twice a day, depending on your healthcare provider's instructions. Be sure to use the medication as directed and do not apply more or less than the recommended amount. Do not cover the treated area with a bandage or dressing unless your healthcare provider tells you to.

If you have any questions about how to apply Skinoren cream or experience any side effects while using the medication, contact your healthcare provider for guidance.

Skinoren Cream and Sensitive Skin

If your skin is very sensitive, you don't have to jump straight into twice-daily use. The Patient Information Leaflet suggests applying Skinoren once a day, in the evening, for the first week of treatment, then increasing to twice a day once your skin has adjusted.

Some local skin irritation is common when you first start – usually mild, and it typically settles as treatment continues. Easing in this way gives your skin time to get used to the cream and can make the first few weeks considerably more comfortable.

Can You Use Skinoren Long Term?

Skinoren isn't a treatment you use indefinitely. To get the best effect, you'll probably need to use it regularly for several months, but you shouldn't use it for more than 12 months at any one time.

Your prescriber will advise on the right length of treatment for you and will want to review how your skin is responding along the way. If your acne returns after you stop, speak to them about your options rather than restarting on your own.

Where to Apply Skinoren 20% Cream

Skinoren can be applied to acne on your face, chest, and back. The amount you need depends on the size of the area you're treating. Around 2.5cm (roughly 0.5g) covers the whole face, and you should adjust the amount accordingly if you're also treating your chest and back.

Skinoren is for external use on the skin only. Don't let it come into contact with your eyes, mouth, or other mucous membranes. If it does, wash the area immediately with large amounts of cool water. If eye irritation carries on after rinsing, seek medical advice.

Skinoren Cream Side Effects and Cautions

Like all medicines, Skinoren can cause side effects, though not everybody gets them. Most are local skin reactions where you've applied the cream, and they tend to be mild and settle as your skin gets used to treatment.

Potential Skinoren Side Effects

Here is a table of the possible side effects from using Skinoren:

 

Very Common

(may affect more than 1 in 10 people)

Common

(may affect up to 1 in 10 people)

Uncommon

(may affect up to 1 in 100 people)

Rare

(may affect up to 1 in 1,000 people)

  • Burning
  • Itching
  • Abnormal redness
     
  • Scaling
  • Pain 
  • Dryness
  • Skin discolouration 
     
  • Greasy skin
  • Loss of skin colour
  • Tingling
  • Dermatitis
  • Discomfort or swelling at application site
     
  • Cracking of lips
  • Small blisters
  • Eczema
  • Ulceration
  • Warmth at application site
  • Allergic reaction
  • Rash at application site

 

These effects occur at the site of application. There's also a group of side effects reported since Skinoren came to market where the frequency can't be estimated from the available data, including swelling of the skin, eyes, or face (which may occur with hypersensitivity), rash, urticaria (hives), and worsening of asthma.

For a more detailed look at possible Skinoren cream side effects, read the enclosed Patient Information Leaflet. If you encounter any adverse reactions to the treatment, you can also report them to the Yellow Card Scheme.

Skinoren Irritation

Local skin irritation happens fairly often with Skinoren, usually at the start of treatment. In most cases, it's mild and gets better as you continue using the cream.

If irritation becomes troublesome, you have a few options before giving up on the treatment:

  • Reduce the amount of cream you apply each time
  • Apply it only once a day instead of twice
  • Stop treatment temporarily to let your skin settle

If the irritation is still troublesome after trying these, tell your prescriber.

Allergic Reaction

It's essential to stop using Skinoren cream and see your doctor as soon as possible if you think you are having an allergic reaction to the treatment. Signs of an allergic reaction include:

  • Rash or hives (urticaria)
  • Swelling of the skin, eyes, or face
  • Worsening of asthma symptoms if you have asthma

If you experience swelling of your face, lips, tongue, or throat, or have difficulty breathing, call 999 or go to A&E immediately.

Skinoren Cream Interactions and Warnings

Skinoren 20% cream is not suitable for everyone, so it's important to speak to a clinician or doctor before starting treatment. You should not use the medication if you are allergic to azelaic acid or any of the other ingredients. It has also been rarely reported that using Skinoren can worsen some asthma symptoms.

Skinoren Cream and Other Medications

No interaction studies have been performed for Skinoren, and no specific medicine interactions are listed in the Patient Information Leaflet. Nevertheless, it's still important to tell your prescriber or pharmacist about any medicines or skin treatments you're using, including other acne products, so they can check that everything works together sensibly.

Be particularly cautious about layering Skinoren with other topical acne treatments, as using several products with drying or irritant effects at once can leave your skin sore.

Pregnancy and Breastfeeding

There's limited experience with using azelaic acid during pregnancy. If you're pregnant, breastfeeding, think you may be pregnant, or are planning a baby, ask your prescriber or pharmacist for advice before using Skinoren.

If you do use Skinoren cream while breastfeeding, infants must not come into contact with treated skin or the breast. Don't apply the cream to your chest area.

Frequently Asked Questions About Skinoren Cream

Can You Use Skinoren For Rosacea?

Skinoren 20% cream is licensed to treat acne, and the Patient Information Leaflet says it shouldn't be used for any other skin condition. Azelaic acid is used in rosacea treatment in other formulations and strengths, but that's a separate product with its own licence.

If you think you have rosacea rather than acne, speak to your prescriber, as the two conditions can look similar but need different treatment.

Does Skinoren Cause Purging?

Skinoren doesn't cause purging as some acne treatments do, but local irritation, redness, and scaling are common in the first few weeks. Acne itself is also listed as an uncommon side effect. Any early flare usually settles as your skin adjusts. If it doesn't, reduce how often you apply it or speak to your prescriber.

Can You Use Skinoren Long Term?

You can use Skinoren for several months, which is often what's needed to get the full benefit. However, you shouldn't use it for more than 12 months at any one time. Your prescriber will advise on the right duration for your skin.

Is Skinoren a Steroid Cream?

No, Skinoren is not a steroid cream. It contains azelaic acid (a dicarboxylic acid, not a steroid) and works by targeting acne-causing bacteria and clearing blocked pores that cause blackheads and whiteheads. Unlike steroid creams, Skinoren can be used for longer periods of time without the risk of side effects such as skin thinning.

Can You Buy Skinoren Over the Counter?

No, you cannot buy Skinoren over the counter as it is classified as a prescription-only medicine (POM) in the UK. Therefore, you'll need a prescription from a qualified healthcare professional before you can get it. This is to ensure the product is safe and suitable for your circumstances.

Can You Buy Skinoren Online?

Yes, you can buy Skinoren cream online from Prescription Doctor after completing a quick online consultation. One of our prescribers will review your answers, and if Skinoren is suitable, your order will be dispatched from our UK-registered pharmacy to your designated address. Orders approved before 3pm on a weekday are also eligible for next-day delivery.

How Do I Store Skinoren Cream?

Store Skinoren below 30°C and keep it out of the sight and reach of children. Don't use it after the expiry date printed on the box. Once you've opened the tube, it has a 6-month shelf life.

Treatment information

Product Name: Skinoren 20% Cream
Active Ingredient(s): Azelaic acid
Manufacturer: LEO Laboratories Limited
Administration: Topical
Presentation: Cream
Available Strength: 20% azelaic acid
Exemption: Prescription-only medication
Application: Men and women over 18 with acne vulgaris
Dosage: Apply to affected areas twice daily, morning and evening. If your skin is very sensitive, apply once daily in the evening for the first week, then increase to twice daily.
Description: Skinoren 20% Cream is a topical acne treatment containing azelaic acid. It targets acne-causing bacteria and reduces the build-up of skin cells that block pores.
Drug Class: Dicarboxylic acid / topical anti-acne preparation
Alcohol Consumption: No specific alcohol restrictions are stated in the Skinoren Patient Information Leaflet or the SmPC.
When Pregnant: Tell our prescribers if you are pregnant, planning a pregnancy, or think you may be pregnant.
When Breastfeeding: Tell our prescribers if you are breastfeeding. Infants must not come into contact with treated skin or the breast.
Prices From: 15.99 GBP

Click here to view the Skinoren Cream - Patient Information Leaflet

Authored By

Sam

Sam Jeans

Medical Content Writer
Sam has been a freelance writer since 2015, with extensive experience in the medical, scientific, and technology fields. He holds an MSc in International Development and Social Anthropology, bringing

Published on: 19/10/2022 Re-Published on: 23/07/2026

Reviewed By

Mohamed Imran Lakhi

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Reviewed on: 23/07/2026

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