The Best Time of Day to Take Mounjaro
When it comes to weight loss on Mounjaro, consistency is key. Quickly establishing a routine is essential to giving yourself the best chance of achieving the potential 22.5% weight loss that’s possible with the medication. This is because having a steady level of Mounjaro’s active ingredient, tirzepatide, in your body helps maintain the treatment’s effectiveness and reduces the likelihood of side effects developing.
Following the Mounjaro dosage schedule (where possible) is a great starting point for achieving the necessary consistency. However, did you know that it’s also advisable to administer the medication on the same day and at the same time each week? This begs the question, ‘When is the best time of day to take Mounjaro?’
To help you solve this crucial conundrum, we’ve put together this dedicated guide that delves into everything you need to know to decide on the best day and time to suit your commitments. Let’s get started.
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When is the Best Time to Take Mounjaro?
The best time to take Mounjaro is at a time that is most convenient for you and your schedule. The only rule concerning when you should be taking Mounjaro is that it should be on the same day and time each week. This makes sure that you have a stable amount of tirzepatide in your body at all times.
Mounjaro works just as well whether you take it first thing in the morning or last thing at night. So, when you take it doesn’t matter, but being consistent does, and choosing a time that’s convenient for you will make it easier to stick to the dosage schedule.
Should I Take Mounjaro in the Morning or at Night?
You can take Mounjaro in the morning, at lunchtime, in the afternoon, or at night. There is no scientific evidence to show that there is a ‘best time to take Mounjaro’. It’s about finding what works best for you. However, there are certain reasons why some Mounjaro users choose to inject their dose at specific times of the day.
Lots of people choose to inject Mounjaro in the evening when they are at their most relaxed. And, if Mounjaro side effects are an issue, injecting at night means that it may be possible to sleep through them, limiting their impact on your daily life.
However, others prefer to administer their dose first thing in the morning, perhaps on a Monday, to start their week and reduce the likelihood of forgetting their dose.
Whatever time you choose is fine, as long as it is convenient for you and something you can stick to in the long term. Being consistent and building a strong routine that involves taking Mounjaro at the same time each week will support your weight loss journey and reduce the chance of missing doses, which can impact your progress.
Do You Have to Take Mounjaro at the Same Time Every Week?
Yes, taking Mounjaro at the same time each day will promote long-term effectiveness. It’s true that Mounjaro works best alongside a calorie-controlled diet plan, and pairing it with exercise is also beneficial; however, consistently injecting at the same time each week is just as important.
Why? Administering Mounjaro in this way ensures a consistent level of tirzepatide in your body. This is important because Mounjaro works by mimicking two important digestive hormones that regulate your appetite. They do this by binding to the glucagon-like-peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors. So, injecting Mounjaro too late may mean there isn't enough tirzepatide in your system to effectively suppress your appetite, causing you to eat more and undo all your hard work.
Mounjaro
- Approved Weight Loss Treatment
- Suitable for adults with a BMI of +30kg/m²
- Pre-filled injection pen
Likewise, injecting too early can increase the risk of side effects, like feeling or being sick, constipation or diarrhoea, which may cause you to question your treatment and increase the chances of you stopping.
But that’s not all. Sometimes life can be hectic, and choosing a specific day and time to administer Mounjaro can help you remember your dose more easily. It won’t take long for this to become a regular habit, much like brushing your teeth.
The Best Time to Take Mounjaro to Avoid Side Effects
Mounjaro side effects are a common occurrence when you first start your treatment or when you titrate (increase) your dose. However, they are usually mild and resolve once your body gets used to the medication. That said, if you do get side effects, they can influence when you inject your dose.
Some people prefer to inject Mounjaro in the morning as this allows them to monitor their side effects, like tiredness or feeling sick, and adjust their daily activities accordingly. While others opt for the evening because they are more likely to sleep through mild side effects, limiting the impact on their day-to-day life.
Let’s not forget the weekend, though. For those of us with busy working weeks or intense childcare schedules, the weekend can be a good time to help you maintain a consistent schedule and manage any potential side effects without impacting the rest of the week.
How to Choose the Best Time to Take Mounjaro
Although there is no clinical evidence that there is a best time to take Mounjaro, there are several factors that can influence when the best time is for you. These can include:
- Side effects: You may choose to inject in the morning to monitor your body’s response, or in the evening to limit the impact of side effects on your daily routine.
- Social and work schedules: Choose a time when you won’t be affected by a social or work schedule. For example, if you have an aerobics class on a Tuesday evening or you work a 9 to 5 job on weekdays, it’s probably best to avoid these times. Instead, choose a time when you will feel relaxed and have no prior plans.
- Meal times: Some people find that injecting Mounjaro just before a light meal can help manage side effects like nausea, while others may prefer to do it after.
- How you feel: Choose a time when you are feeling relaxed and not stressed or rushed to inject your medication.
These are just a few of the considerations to bear in mind when choosing the best day to inject Mounjaro. Don’t forget that Mounjaro is intended to be taken long-term for weight loss, so it is important to pick a day that you can stick to each week without needing to frequently change.
The Best Time of Day to Take Mounjaro: FAQs
Selecting the best time of day to take Mounjaro can lead to further questions about dosage and how to take it. Here we’ve tried to answer some of the most common questions related to when to take Mounjaro to help you get the most out of your treatment.
Is it OK to Miss a Dose of Mounjaro?
Ideally, you should try to avoid missing a dose of Mounjaro whenever possible, but there are times when this may be unavoidable, and it should not disrupt your schedule. You will just need to follow the instructions in the patient information leaflet that accompanies the medication.
If you do miss a Mounjaro dose and it has been:
- 4 days or less since you should have had your injection, take it as soon as you remember and then inject your next dose at your normal time.
- More than 4 days since you should have injected Mounjaro, skip the missed dose and then inject your next dose as usual.
Can I Change the Day I Take Mounjaro?
Yes, it is possible to change the day you take Mounjaro, but you will need to make sure your last dose was administered at least 3 days ago. You can then choose a day that suits you best.
For example, if you usually inject Mounjaro on Monday at 9am and you want to change to Tuesday at 7pm, you’ll need to wait until the following Tuesday (8 days).
Mounjaro
- Approved Weight Loss Treatment
- Suitable for adults with a BMI of +30kg/m²
- Pre-filled injection pen
When you have changed your injection day, it is best to stick to the same day and time each week. Changing your Mounjaro dose frequently may impact its effectiveness. If you’re ever unsure about changing your injection day, it’s a good idea to consult our clinicians beforehand.
Can I Change the Time of My Mounjaro Injection?
Yes, sometimes you may need to change the timing of your injection. For example, adjusting the time may make side effects more manageable. If you are travelling with Mounjaro, your clinician may advise you to slightly adjust the time you take it, rather than skipping a dose or changing your injection day.
Changing the time of day shouldn’t be a problem, but if you are concerned, you should speak to your clinician for further advice.
Why is There a Dosage Schedule for Mounjaro?
The Mounjaro dosage schedule is an important part of your weight loss journey. The active ingredient, tirzepatide, is powerful, so it is essential to gradually build up your tolerance to help your body adjust to Mounjaro and minimise the risk of side effects.
When you first start your treatment, you’ll begin on the lowest 2.5 mg per week dose, which is gradually increased every four weeks until you reach the maximum 15 mg weekly dose. However, this schedule can be tailored to your individual circumstances. So, if you are getting side effects at a specific dose, it is possible to stick to your current strength for longer to give your body more time. You can also remain on a lower dose if you think it is beneficial for you.
Once you have familiarised yourself with the Mounjaro dosage schedule, you can learn more about how much weight you can lose on Mounjaro in our expert guide. Then, check out our before-and-after weight loss success stories for some personal, real-life insights into losing weight with Mounjaro.
Prescription Doctor: Your Expert Weight Loss Guide
Weight loss can sometimes feel like an isolating journey that’s daunting to go through alone. Thankfully, Prescription Doctor is here to help. We’ve developed a comprehensive consultation service that’s designed to support you every step of the way, from providing licensed medication to offering regular check-ups to ensure everything is progressing as it should.
We understand that having as much information as possible about weight loss injections can help you feel confident about your treatment regimen, which is why we’ve put together a library of resources covering a wide range of topics. So, if you’d like to know what you should eat on Mounjaro, the types of exercises to do, what vitamins to take, or even learn about the different injection sites, we have you covered.
You can also compare Mounjaro to the alternative weight loss treatments, including Wegovy and Nevolat, to help you make a more informed treatment choice.
Join the many people who have chosen us as their preferred weight loss partner and become one of the latest Mounjaro success stories today. Start your weight loss consultation now.
Sources
- EMC (2025): Mounjaro KwikPen 2.5mg solution for injection in pre-filled pen.
- NEJM (2021): Tirzepatide Once Weekly for the Treatment of Obesity.
- NHS (2023): Obesity Treatment.
Authored By
Leanne Edermaniger
Medical Content WriterPublished on: 05/09/2025
Reviewed By
Mohamed Imran Lakhi
MPharm - Lead PharmacistReviewed on: 05/09/2025
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