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Naproxen 250mg & 500mg Tablets

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Naproxen 500mg Gastro-resistant 56 tablets
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  5. If you get the green light and it is deemed suitable, your order will be processed quickly and efficiently.
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We deliver medications between Monday and Saturday. You can upgrade to Saturday delivery on Friday.

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Patient Reviews: How Naproxen 250mg & 500mg Tablets Has Made a Difference

Treatment Information

Table of contents:

Buy Naproxen 500mg Online

You can buy Naproxen 500mg online from Prescription Doctor.

Our online pharmacy prescription service makes it easy and convenient for you to receive treatment delivered directly to your door.

All medicines are MHRA-approved and dispatched from a UK-registered pharmacy.

How Does Naproxen Work?

Naproxen works by blocking the production of certain prostaglandins (a group of lipids with hormone-like actions that your body makes primarily at sites of tissue damage or infection). These chemicals in the body cause inflammation and pain.

It is used to reduce pain, swelling and inflammation from a variety of conditions, including arthritis, plantar fasciitis, gout and menstrual cramps. It can also be used to reduce fever and as a pain reliever for mild to moderate headaches.

Naproxen works by blocking the action of certain natural substances in the body that cause pain and inflammation. It does this by inhibiting the synthesis of prostaglandins, substances that play a role in pain and inflammation.

Naproxen helps to reduce pain, swelling and tenderness associated with arthritis, strains, sprains, and other minor injuries.

How long does Naproxen take to work?

The effects of Naproxen should be noticeable after an hour of taking it. However, it may take up to 3 consecutive days of taking Naproxen to reach peak effectiveness.

If you feel you need to take Naproxen for longer or you don't notice an improvement in your symptoms, speak to one of our online doctors.

Naproxen Prices

StrengthQuantityPrice
250mg56 tablets£18.99
250mg112 tablets£38.99
500mg28 tablets£13.99
500mg56 tablets£18.99
500mg112 tablets£38.99
250mg GR56 tablets£18.99
500mg GR28 tablets£22.99

How Do I Take Naproxen?

Naproxen tablets are taken twice daily with food to help prevent stomachache.

You should take Naproxen around the same time every day.

Taking Naproxen alongside breakfast and your evening meal can help you take them consistently and reduce the risk of side effects, such as a stomachache.

Naproxen tablets should be swallowed whole with a glass of water.

You should take the smallest quantity of Naproxen for the shortest time. Our online doctor will prescribe the most suitable dose for you during your consultation.

Can I take Naproxen with other medicines?

You should not take Naproxen with other anti-inflammatory medicines, such as Ibuprofen. 

But you can take Naproxen with paracetamol.

If you are unsure about what medications you can take Naproxen with, consult your doctor or pharmacist.

What should I do if I forget to take Naproxen?

If you forget to take Naproxen, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue taking Naproxen as usual.

Do not take a double dose of Naproxen to make up for a missed dose.

What should I do if I accidentally take too much Naproxen?

If you accidentally take too many Naproxen tablets, seek immediate medical attention.

Go directly to your nearest accident and emergency department. Remember to take the packaging and remaining medicine with you so that doctors treating you know precisely what and how much you took.

Side effects and cautions

Naproxen has the potential to cause side effects. Moreover, Naproxen may not be suitable for you or your condition. When you order Naproxen online from Prescription Doctor, our online doctors will review your medical questionnaire to ensure it is safe for you.

Before taking Naproxen, please read the enclosed patient information leaflet. This leaflet provides essential instructions on how to use and store Naproxen, as well as other important safety information.

Who should not take Naproxen?

Naproxen is not suitable for everyone. If you are unsure whether it is safe for you, consult your doctor before taking Naproxen.

Do not take Naproxen if you:

  • are allergic to aspirin or other NSAIDs
  • are allergic to Naproxen or any of the other ingredients listed in the patient information leaflet
  • are breastfeeding
  • are in the last three months of pregnancy
  • had two or more instances of peptic ulcers, bleeding or perforation of the stomach
  • have or had stomach ulcers, duodenum ulcers, bleeding of the stomach or intestines
  • have severe liver, kidney or heart failure

If you are not sure whether any of the above apply to you, speak to your doctor.

Side effects of Naproxen

All medicines carry the risk of side effects, though not everybody who takes Naproxen will experience them. It's essential to familiarise yourself with the list of associated side effects and to remain vigilant about these side effects throughout your course of treatment.

Common side effects of Naproxen:

  • Changes in vision
  • Confusion
  • Dizziness
  • Drowsiness
  • Headache
  • Rash
  • Ringing in the ears
  • Tiredness

Uncommon side effects of Naproxen:

  • Abnormal dreams
  • Depression
  • Difficulty concentrating
  • Difficulty sleeping
  • Forgetfulness
  • Irregular heartbeat (palpitations)
  • Sensitivity of the skin to light (may cause blistering)

This is not an exhaustive list of side effects. Further information regarding the safety of Naproxen, including a complete list of side effects, can be found within the patient information leaflet enclosed within the packaging of your medication.

If you experience any side effects after taking Naproxen, regardless of whether they are listed above or in the patient information leaflet, report them to your doctor straight away.

Allergic reaction

Do not take Naproxen if you are allergic to Naproxen or any of the other ingredients listed in the patient information leaflet.

If you experience an allergic reaction after taking Naproxen, stop taking the medicine and go straight to your nearest accident and emergency department. Remember to take the packaging and remaining Naproxen tablets with you so that doctors know exactly what you have taken.

Signs of an allergic reaction include:

  • Chest tightening
  • Dry, red and cracked skin
  • Itchy, red, watery eyes
  • Raised, itchy, red rash (hives)
  • Swelling of the lips, tongue, eyes or face
  • Tummy pain, nausea, vomiting or diarrhoea
  • Wheezing

Pregnancy and breastfeeding

Do not take Naproxen if you are pregnant, think you might be pregnant, are trying to become pregnant or are breastfeeding.

Naproxen may affect female fertility and make it more difficult for you to conceive. If this is a significant concern for you, consult your doctor.

For further information, speak to your doctor or our online clinician.

Frequently Asked Questions

Will Naproxen affect my ability to drive or operate machinery?

Naproxen may cause dizziness, drowsiness or changes in vision. If you experience any of those side effects, you should not drive or operate machinery until you feel safe.

Can I drink alcohol while taking Naproxen?

You should not drink alcohol while taking Naproxen. Drinking alcohol while taking Naproxen can exacerbate irritation to the stomach and increase your risk of side effects such as heartburn and stomach bleeding.

Does Naproxen cause stomach aches?

Naproxen can cause stomach aches. If you experience any stomach pain that you believe is caused by Naproxen, speak to your doctor.

You can take Omeprazole alongside Naproxen to protect your stomach. Our doctor can issue a prescription for Omeprazole if you require it.

Why can't you lie down after taking Naproxen?

Naproxen can irritate the stomach lining and cause gastroesophageal reflux or heartburn. Therefore, it is recommended not to lie down shortly after taking medicine.

If you experience heartburn after taking Naproxen, speak to your doctor or ask a pharmacist for advice. Our online doctor may also be able to prescribe a heartburn treatment to take alongside Naproxen to prevent this side effect.

Can I take Naproxen and Ibuprofen together?

It is not recommended to take Naproxen and Ibuprofen together. This is because NSAIDs can irritate the lining of the stomach. Taking more than one NSAID can increase your risk of gastrointestinal problems such as stomach ache, heartburn, stomach ulcers, bleeding of the stomach and, in very rare cases, perforation of the stomach.

Can I take Naproxen with Paracetamol?

Yes, you can take Naproxen with paracetamol and opioid painkillers, such as Tramadol. However, you should only take pain relief medication for a short while. If you are unsure about what you can and cannot take with Naproxen, ask your doctor or a pharmacist for advice. Information on how to safely take Naproxen can be found in the patient information leaflet enclosed with your medicine.

How long can you take Naproxen?

How long you should take Naproxen depends on the reason you are taking it. For period pain, you may only need to take Naproxen for 1 or 2 days. People with chronic pain conditions, such as arthritis, may need to take Naproxen for longer. You should discuss your condition with your doctor - they will be able to determine how long you should take Naproxen to manage your condition.

Is Naproxen addictive?

Naproxen is not an addictive substance. However, if you find yourself using more Naproxen than prescribed to manage your condition, speak to your doctor. They may be able to prescribe an alternative pain medication that may be more suitable for you.

Will Naproxen affect my fertility?

According to the NHS, Naproxen and other NSAIDs in large quantities for extended periods may affect fertility in women. There is no substantial evidence to suggest that NSAIDs affect male fertility. If you are concerned about how a medication may affect your fertility, speak to your doctor or ask a pharmacist.

Will Naproxen affect my contraceptive?

Naproxen does not reduce the efficacy of contraceptive pills, including the combined contraceptive pill, the progestogen-only pill (mini pill) or the emergency contraceptive pill. If you have any concerns about how Naproxen may affect your contraception, ask one of our online doctors.

Is Naproxen available over the counter in the UK?

Naproxen can only be bought on prescription in the UK. Our registered prescribers are on hand to issue prescriptions for Naproxen. To renew your Naproxen prescription, complete our brief medical questionnaire for our doctor's review.

References

NHS, 2018. Naproxen.

Accord-UK Ltd, 2019. Naproxen 250mg Gastro Resistant Tablets: Summary of Product Characteristics

Additional Resources

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How to relieve stomach ache after taking Naproxen?

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that relieves pain and swelling in many inflammatory conditions. It is used to treat acute gout, arthritis, migraines, and primary dysmenorrhea, among others, to ease pain and swelling.But like other NSAIDs, a significant side effect associated with Naproxen is causing gastrointestinal problems (stomach problems), including indigestion, gastric (stomach) or duodenal (large intestine) ulceration, bleeding, and other issues that cause extreme abdominal discomfort. According to the British Medical Journal, 60% of people taking NSAIDs experience indigestion troubles.Why does Naproxen cause stomach pain?Naproxen interferes with the stomach's mucosal lining, protecting the stomach from gastric acids. While these acids are vital to the normal digestion process, in the absence of protective barriers, they can cause damage to the mucosal lining, causing ulcers and bleeding.The stomach has protections against gastric acid due to the:Mucus: produced by the cells in the stomachBicarbonate: which helps neutralise stomach acidBlood circulation: aids in the repair and renewal of cells in the stomach's mucosal layerProstaglandinsNaproxen reduces pain by blocking the enzymes involved in producing prostaglandins, which play a significant role in protecting the mucosal layer of the stomach. The suppression of prostaglandins can compromise the stomach's protective lining, leading to inflammation and damage to a capillary or blood vessel, which may result in bleeding and the development of a sore in the mucosal lining.Naproxen also slows the production of protective mucus in the stomach and changes its structure.What are the symptoms of a stomach ulcer?According to the NHS, the most common symptom of a stomach ulcer is dull or burning pain in the upper abdominal area (where the stomach is located). It can range from mild to severe pain.Typically, the pain occurs after a meal, but it may also happen at night for some individuals. It could go on from a few minutes to a few hours.Other less common symptoms are:Pain after eatingIndigestionHeartburnLoss of appetiteFeeling and being sickWeight lossIn some cases, people with peptic ulcers may see blood in their vomit or stool or have black stools because they contain blood.Call your doctor immediately if you notice blood in your stool or vomit. This can be a sign of excessive bleeding or other serious problems.In about half of all diagnosed cases of ulcers caused by anti-inflammatory medicines, there are no symptoms. This can make it tricky for doctors to diagnose peptic ulcers early.But what can you do to avoid stomach pain and the risk of ulcers while using Naproxen? Continue reading to discover ways to prevent or alleviate the symptoms.What can you do to prevent stomach aches when taking Naproxen?There are some preventive measures to avoid stomach aches from Naproxen, such as:Avoid taking Naproxen on an empty stomach. It is also essential that you take Naproxen with food or just after eating. This will help to protect your stomach lining and avoid pain.Avoid alcohol and smoking while taking Naproxen, as these aggravate the stomach problem.Take Naproxen in the evening.Often, a medication called a proton pump inhibitor (PPI) is prescribed alongside Naproxen.Proton pump inhibitors such as omeprazole protect the stomach when taking an NSAID like Naproxen. They work to inhibit the production of stomach acid, which significantly reduces the risk of stomach ulcers and other gastric problems.Proton pump inhibitors are commonly prescribed to treat acid reflux, stomach ulcers and gastro-oesophageal reflux disease (GERD).Naproxen can also cause stomach ulcers if taken long-term without a stomach protector. For this reason, you should only take the minimum amount to reduce pain. Your doctor will discuss the most appropriate dosage of Naproxen for you. If you are taking Naproxen for an extended period, taking a proton-pump inhibitor, such as omeprazole or lansoprazole, can help mitigate the gastrointestinal side effects of Naproxen.ConclusionNSAIDs such as Naproxen may cause gastric ulcers, bleeding, and holes in the oesophagus (tube between the mouth and stomach), stomach, or intestine. These problems may develop anytime during treatment, happen without warning, and can be fatal.The risk may be higher for people taking NSAIDs for a long time or at higher doses, are older, have poor health, smoke, or drink large amounts of alcohol while taking Naproxen.Keep a close check on symptoms of an ulcer. You can check your symptoms by getting the SELFCheck Stomach Ulcer Test. This test kit contains everything you need to check for stomach ulcers at home and provides results within minutes.Speak to your pharmacist or a doctor about taking a stomach protector while taking Naproxen. You can talk to one of our online prescribers at Prescription Doctor by using the “my chats” function under “my account”. They can suggest a proton pump inhibitor to protect your stomach while taking Naproxen or other NSAIDs.
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How to relieve stomach ache after taking Naproxen?
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Is Naproxen a strong painkiller?

Naproxen is from a class of medicines called non-steroidal anti-inflammatory drugs, or NSAIDs. It is known for its effective pain relief and ability to reduce swelling in a variety of musculoskeletal conditions, particularly in arthritis. NSAIDs are a group of medicines which bring pain relief, so it is useful to compare them against other NSAIDs (e.g. ibuprofen, diclofenac, celecoxib) to understand their potency better.At a glance:Naproxen may provide better long-term pain relief compared to ibuprofen, but ibuprofen works fasterAll NSAIDs are similar in terms of the 'strength’ of pain reliefThe decision between one NSAID and another is based on the side effect profileWhat is Naproxen?To get a better idea of naproxen’s potency, we need to briefly look at how it works. Like many NSAIDs, naproxen targets cyclooxygenase (COX) enzymes. It does so because COX enzymes produce chemicals called prostaglandins, which result in pain and inflammation. By blocking these enzymes, naproxen reduces prostaglandin levels, thereby reducing pain and inflammation.Due to its pain-relieving effect, it can be used to treat various conditions, including headaches, joint and muscle pains, and even menstrual cramps.{add_product_block(183)}Is Naproxen ‘strong’ compared to other painkillers?Naproxen is available in two different strengths: 250mg and 500mg. At 500mg, it should be taken at most twice a day.Naproxen 500mg VS IbuprofenWhen naproxen is taken, peak levels of the drug are reached in the body after 2-4 hours. Ibuprofen, however, only takes 1-2 hours. This means that ibuprofen works faster, i.e., it has a faster onset of action. Therefore, for acute pain relief, ibuprofen is a more effective option. However, ibuprofen is also cleared from the body a lot quicker.The half-life of a drug is the time it takes for the drug concentration in the body to halve – it is used to give a measure of how fast a drug is cleared from the body. The half-life of ibuprofen is approximately 2 hours, whereas that of naproxen is considerably longer, ranging from 12 to 15 hours.This means that naproxen provides ‘longer-lasting’ pain relief, which is why naproxen 500mg is taken twice a day, whereas ibuprofen 400mg is taken up to three times daily. Note that two different drugs may have different strengths, but this does not mean the higher strength of one drug is more potent. E.g. 600mg of Drug X may be less potent than 25mg of Drug Y.From this, naproxen may be better suited towards ‘long-term’ chronic pain, such as muscle aches, whereas ibuprofen may be better for acute, short-term pain like headaches.Which is the strongest NSAID?There is no definitive ‘strongest’ NSAID, as they all work similarly, i.e., by inhibiting COX enzymes. They differ in their selectivity for COX enzymes (which are distinct, e.g., COX-1, COX-2), resulting in variability in individual responses and an increased likelihood of side effects.Naproxen 500mg compared to other NSAIDsWith the above said, the reason behind one NSAID being preferred over another is often due to its side effect profile. All NSAIDs can cause gastrointestinal side effects (stomach upsets), hence why they are advised to be taken with food to reduce this risk.Likelihood of gastrointestinal side effects:Medium risk: naproxen, diclofenacLow risk: ibuprofenSome NSAIDs are more selective towards COX-2 enzymes (e.g. Celecoxib), which have a lower risk of serious stomach and upper belly side effects, e.g. stomach pain, nausea and vomiting.NSAIDs can lead to a slightly increased risk of cardiovascular events. Naproxen (1g daily) and up to 1.2g of ibuprofen are considered low-risk. However, the maximum dose of ibuprofen is 2.4g daily, which would increase this risk.Can anyone take Naproxen?Naproxen is not suitable for everyone. As an NSAID, it interacts with certain medicines. This includes some medicines which can be bought over the counter in a pharmacy (e.g. pseudoephedrine), so it is worth mentioning to your pharmacist during purchase.It may not be suitable for individuals with specific conditions. These include asthma, high blood pressure (hypertension) and kidney/liver problems. Some individuals are allergic to NSAIDs, so if any of the above apply, it is important to speak to your doctor or pharmacist first.ConclusionYou may find more benefits in a particular NSAID compared to someone else. In fact, roughly 60% of individuals will respond to any NSAID. Even though they work in a similar way, your body may respond better to a particular one. Therefore, if you have found naproxen to be ineffective, speak to your doctor. A straightforward switch may be all that is required for some much-needed pain relief!SourcesNICE. Non-steroidal anti-inflammatory drugs
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Is Naproxen a strong painkiller?
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How Long Does Naproxen Take To Work?

If you've experienced the symptoms of gout or another debilitating pain, you'll know how it can affect your sleep and work due to the discomfort and irritation it causes.If this is the case, your doctor may have prescribed you Naproxen - a commonly prescribed painkiller that has been proven to be effective for gout and relatively fast-acting. It is particularly beneficial for inflammatory conditions.If you have been prescribed Naproxen to relieve painful swelling, you may be wondering how long it takes to work. Read on to find out how long this anti-inflammatory takes to work and what can affect its onset of action.What Is Naproxen?Naproxen is a pain-relieving medication that falls under the category of nonsteroidal anti-inflammatory drugs (NSAIDs). It is usually prescribed for individuals with pain stemming from joint and muscle inflammation, such as arthritis and gout. However, it can also be used to manage general pain, including toothaches and menstrual cramps.In most cases, Naproxen is taken as tablets or capsules that you swallow, although it is also available as a liquid if you have difficulty swallowing.Naproxen blocks enzymes that produce pain-causing chemicals in the body, known as prostaglandins. Prostaglandins cause blood vessels to dilate and swell, which leads to inflammation and pain. By blocking the enzyme, these chemicals can’t be produced, and so pain and swelling subside.{add_product_block(183)}How Long Does Naproxen Take To Work?As with most medications, how well and how quickly you respond to Naproxen will depend on many factors, including the dosage, duration and reason you are taking it.In most cases, Naproxen starts working about 1 hour after it is taken. However, it can take up to 3 hours to reach its highest efficiency.In situations where you are taking Naproxen twice a day to treat a chronic condition, it can take up to 3 days for it to reach its peak effectiveness.It is often recommended to take Naproxen with or straight after a meal. While taking Naproxen on an empty stomach may increase the rate at which the medicine is absorbed, it has been perceived that doing so may increase your risk of developing stomach ulcers.There is no evidence to suggest that liquid Naproxen works faster than Naproxen in pill form, although liquid medications are generally absorbed more quickly and can take effect faster.How Long Does Naproxen Last For?After taking Naproxen, its analgesic and anti-inflammatory effects should last for between 8 and 12 hours.Naproxen is not recommended for long-term use and may only be prescribed for one or two days. Naproxen may become less effective when taken for an extended period.Regarding gout, Naproxen will usually be prescribed only for as long as the attack lasts.How Often Can I Take Naproxen?The best person to determine the dose and frequency of Naproxen for your specific condition and situation is your doctor. A doctor will usually prescribe Naproxen for the shortest amount of time and in the lowest dose to manage your condition.Most people who are prescribed Naproxen should take it as needed, once every 8 hours.For long-term pain issues, like arthritis, you may need to take Naproxen for a longer period to effectively control your condition. Once your pain subsides, you can stop taking Naproxen until another flare-up occurs.Tell your doctor if you feel Naproxen doesn’t relieve your pain effectively. Your doctor may amend your dose or prescribe a different medication entirely. Do not take more in an attempt to increase its effectiveness. Taking more Naproxen than prescribed can increase your risk of side effects.Can Naproxen Be Taken With Other Pain Medication?According to the NHS, Naproxen can be taken with some other pain relief, such as paracetamol or co-codamol, to manage your pain further.However, you should not take Naproxen alongside other NSAIDs, such as Ibuprofen. Taking more than one anti-inflammatory at a time is dangerous.If you are unsure whether a medicine is suitable to take alongside Naproxen, ask your doctor or a pharmacist.In short, Naproxen is an effective analgesic that can start working to reduce inflammation within 2 to 3 hours of taking it, although it may take longer for some individuals.To avoid stomach ulcers when taking Naproxen, your doctor may prescribe a stomach protector (e.g. Omeprazole) at the same time. However, gastro-resistant variations are available. These can be taken on an empty stomach due to their special coating, which prevents them from causing damage to the gastrointestinal tract.Key FactsTake naproxen with or just after a meal or snack.Take a low dose of naproxen for the shortest time to control your symptoms.Common side effects of naproxen include headache, confusion, changes in vision, ringing in the ears, fatigue, drowsiness, dizziness, and rashes.For strains, sprains, and pains, some physicians recommend waiting 48 hours before taking naproxen, as it may slow down the healing process. If you've been taking naproxen for a long time or are at risk of getting a stomach ulcer, your doctor may prescribe a medicine, such as omeprazole or lansoprazole, to protect your stomach.
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How Long Does Naproxen Take To Work?

Treatment information

  • Product Name: Naproxen
  • Active Ingredient(s): Naproxen sodium
  • Administration: Oral
  • Presentation: Tablets
  • Available Strength: 250mg or 500mg
  • Exemption: Prescription only
  • Dosage: Take twice daily with food
  • Description: Naproxen is an anti-inflammatory medication commonly used for arthritis
  • Drug Class: NSAID
  • Alcohol Consumption: Avoid or limit alcohol consumption
  • When Pregnant: Please inform our doctor if you are pregnant before taking Naproxen
  • When Breastfeeding: Please inform our doctor if you are breastfeeding before taking Naproxen
  • Price: 13.99 GBP
  • https://www.prescriptiondoctor.com/storage/product_images_th/Naproxen.jpg
Click here to view the Naproxen 250mg & 500mg Tablets - Patient Information Leaflet

Authored & Reviewed By

Mohamed Imran Lakhi

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 25/10/2019 Reviewed on: 13/03/2024

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