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Gliclazide

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About Product
This content has been written and checked for quality and accuracy by
Adil Bhaloda Pharmacist GPhC: 2086262 Updated on: 29/01/2021 Next review: 29/07/2021

Buy Gliclazide tablets online for diabetes

You can buy Gliclazide tablets online from Prescription Doctor’s trusted online pharmacy. Simply complete our online medical questionnaire to begin your order of Gliclazide.

If your order for Gliclazide is approved before 3pm, Monday to Friday, our UK based pharmacy can dispense and dispatch Gliclazide the same day via a fast next-day delivery.


What is Gliclazide?

Gliclazide is used in patients of non-insulin-dependent type 2 diabetes in adults when exercise, diet and other lifestyle changes are inadequate at controlling blood sugar levels.

Gliclazide belongs to the sulphonylurea class of medicines. This class of medicines lower blood sugar levels by increasing the production of a hormone called insulin.

Insulin is used to move glucose from the blood and into the cells. Glucose is the main source of energy for our bodies.

Short-acting and long-acting Gliclazide tablets are only available on prescription.


How does Gliclazide work?

In type 2 diabetes, the pancreas does not produce a sufficient amount of insulin to metabolise glucose and control sugar levels. The body cells also become resistant to insulin, causing an increase in blood sugar levels.

Glucose levels in the blood

Gliclazide works by stimulating the insulin-producing beta cells in the pancreas to produce more insulin, lowering sugar levels in the blood.

After a meal, Gliclazide also improves insulin production immediately, called early or first phase insulin secretion. The increase in insulin production lowers blood sugar, as it promotes glucose uptake from the bloodstream into nearby cells to use it for energy.

Gliclazide prevents blood cells called platelets from clumping together in the blood vessels and increases the breakdown of blood clots in the blood vessels. It can help prevent the long-term complications of diabetes, partly due to changes in the blood vessels caused by these mechanisms.

Your doctor can prescribe Gliclazide in combination with other diabetes medications such as biguanides, alpha-glucosidase inhibitors or insulin.


How do I take Gliclazide?

The dose of Gliclazide may vary depending on your blood sugar levels and as prescribed by your doctor.

Your doctor will prescribe the appropriate dose depending on the type of tablets you are taking, and your blood sugar levels.

Swallow Gliclazide tablets whole with a glass of water.

Do not crush or chew the tablets. If you have difficulty swallowing tablets, speak to your doctor.

Take Gliclazide before breakfast. If you are prescribed the medicine twice a day, take one dose before breakfast and one dose before an evening meal.

Standard release Gliclazide tablets release the medicine immediately. This means you have to take them several times a day. While slow-release tablets dissolve slowly and do not require frequent doses, an early morning dose is usually enough.

For standard-release Gliclazide, the maximum daily dose is 320mg. If you are prescribed with more than 160mg a day, take the tablets twice a day with breakfast and dinner.

For slow-release Gliclazide, the maximum daily dose is 120mg once a day before breakfast.

If you are unsure how to take Gliclazide, speak to your doctor.

What if I forget to take Gliclazide when I should?

If you forget to take Gliclazide when you should, leave out the missed dose and continue to take the next dose when it is due.

Do not take more Gliclazide than prescribed to make up for the missed dose.

What should I do if I take too much Gliclazide?

If you mistakenly have taken more Gliclazide than you should, seek medical help immediately by going to your nearest accident and emergency department. Taking too much Gliclazide can cause a severe drop in blood sugar level (hypoglycaemia). Take your medicine packaging with you as it will help doctors treating you.

Do not drive yourself to the hospital. Ask someone to take you.


Gliclazide side effects and cautions

Before you buy Gliclazide, it’s important to speak to your doctor to ensure that Gliclazide is safe for you. They will be able to assess your suitability based on your medical history.

You should always read the patient information leaflet which comes enclosed with your medicine before you take it. The patient information leaflet contains important information about its safety, as well as instructions on how to take Gliclazide, what to do in the case of taking too much, as well as a complete list of side effects.

You can view the patient information leaflet for Gliclazide online.

Who should not take Gliclazide?

Gliclazide is not suitable for everyone. If you are unsure whether it is safe for you to take Gliclazide, speak to your doctor.

You should not take Gliclazide if you:

  • have insulin-dependent type-1 diabetes
  • have ketone bodies and sugar in your urine (keto-acidosis)
  • have diabetic pre-coma and coma
  • have severe kidney or liver disease
  • are taking miconazole (for fungal infection)
  • are breast-feeding

What medicines interact with Gliclazide?

Some medicines may interfere with the mechanisms of Gliclazide. It isimportant to inform our online prescriber of all medicines you are currently taking - there is an option on the medical form to list the medicines you are currently taking when you buy Gliclazide online from Prescription Doctor.

Inform a doctor or pharmacist before buying Gliclazide if you are taking:

  • other medicines to treat high blood sugar (anti-diabetics, insulin or GLP-1 receptor inhibitors)
  • antibiotics
  • medicines to treat high blood pressure or heart failure (beta-blockers or ACE inhibitors)
  • medicines to treat fungal infections
  • medicines to treat ulcers in the stomach or duodenum (H2 receptor antagonists)
  • anti-depressants
  • painkillers or antirheumatics
  • medicines containing alcohol
  • St John’s Wort (hypercium perforatum)

You should not stop taking a medicine prescribed to you without speaking to your doctor first. Your doctor will be able to discuss whether you will need adjustments to medicines you are already taking.

Gliclazide side effects

All medicines carry the risk of side effects, though not everybody experiences them. It’s important to familiarise yourself with the side effects listed in the patient information leaflet, and remain aware of them throughout your course of treatment.

Common Gliclazide side effects include:

  • Abdominal pain
  • Diarrhoea
  • Low blood sugar levels (hypoglycaemia)
  • Nausea

This is not an exhaustive list of side effects. Further information regarding the safety of Gliclazide, including a complete list of side effects, can be found within the patient information leaflet enclosed with your medicine.

If you experience any side effects after taking Gliclazide, regardless of whether they are listed above or in the patient information leaflet, you should inform your doctor for advice.

Allergies

Do not take Gliclazide if you are allergic to Gliclazide or have had an allergic reaction to another medicine of the same group (sulfonylureas).

If you experience an allergic reaction after taking Gliclazide, stop taking Gliclazide and seek immediate medical attention by going directly to your nearest accident and emergency department. Remember to take the packaging and any remaining medicine with you so that the doctors treating you know exactly what you have taken.

Signs of allergic reaction include:

  • Chest tightness and pain
  • Dry, red and cracked skin
  • Itchy, red and watery eyes
  • Raised, itchy, red rash (hives)
  • Swelling of the lips, face, tongue or throat
  • Tummy pain, nausea, vomiting or diarrhoea
  • Wheezing

Other safety information

Do not take Gliclazide past the expiry date printed on the packaging. The date refers to the last day of the specified month. For example, “EXP: 03/25” refers to the 31st of March 2025.

Always store medicine out of sight and reach from children and pets.

Never throw away medicines via household or water waste. Take any unwanted or expired medicines to your local pharmacy and asking them to dispose it for you. This can protect the environment.

Never share your medicine with anybody else, even if they are experiencing the same symptoms or have been diagnosed with the same condition as you.


Frequently asked questions

How do I buy Gliclazide online?

To buy Gliclazide online from Prescription Doctor, start by completing our short online medical questionnaire. This is passed on to our doctor for review.

The doctor will contact you via your messages. To access your messages, go to "My Account" and then "My chats". From here, you can send a message to our customer services team or our doctor.

Our doctor may request previous evidence that you have been prescribed the requested medicine. You can upload evidence of a previous prescription to the medical form or to your profile.

If our doctor approves your order before 3pm on a weekday, our UK based pharmacy will dispense and dispatch your item the same day via a fast and discreet next-day delivery service.

Can I take Gliclazide while pregnant or breastfeeding?

Do not take Gliclazide if you are pregnant, think you might be pregnant, or are planning a pregnancy. Speak to your doctor for further advice.

Do not take Gliclazide if you are breastfeeding. Speak to your doctor for further advice.

Can I drink alcohol while taking Gliclazide?

It is safe to drink alcohol in moderation when taking Gliclazide.

Do not exceed more than 14 units of alcohol per week, as per government guidelines. Consuming more than the recommended units can cause a decrease in blood sugar levels and increases your risk of side effects.

Will Gliclazide affect my contraception?

While Gliclazide does not interfere with contraceptives, your doctor may need to adjust your Gliclazide dose if you start taking a combined contraceptive pill. This is because some combined contraceptive pills can increase your blood sugar levels. For further advice, speak to your doctor.

Will Gliclazide impact my ability to drive or operate machinery?

Gliclazide may cause disturbances to vision or lower the blood sugar level, interfering with your ability to concentrate and cause dizziness. If you experience hypoglycaemia, avoid driving or operating machinery until it is safe for you to do so.

Diabetes can impact your ability to drive or operate machinery. For more information, visit diabetes.org.uk for further information or speak to your doctor for advice.

Can Gliclazide cause weight gain?

Gliclazide can cause water retention or increase your urge to eat more by increasing hunger. It is essential to eat a healthy and balanced diet by controlling portion size and lead an active lifestyle to avoid weight gain.

Can I buy Gliclazide over the counter?

No, you cannot buy Gliclazide over the counter. Gliclazide is only available on prescription.

How long do I need to take Gliclazide for?

Treatments for diabetes, such as Gliclazide, are usually taken for the rest of your life.

Do not stop taking Gliclazide unless your doctor has told you to.

Do I need to avoid any foods while taking Gliclazide?

While there are no specific foods to avoid, you should generally avoid food and drinks high in sugar, such as cakes, sweets, full sugar fizzy drinks and juice drinks.

Do painkillers interfere with Gliclazide?

Some painkillers, such as aspirin and ibuprofen, can interact with Gliclazide.

However, you can safely take paracetamol with Gliclazide.

For further advice on what medicines may interact with Gliclazide, speak to your doctor or a pharmacist.

Why does Gliclazide need to be taken with food?

Gliclazide is usually taken before a meal, such as breakfast or dinner, to reduce the side effects which affect the stomach and gut, such as diarrhoea and stomach ache.

Can Gliclazide be taken alongside Metformin?

Gliclazide is sometimes prescribed alongside Metformin. While the two medicines work slightly differently - with Metformin affecting the amount of sugar produced by the liver, and Gliclazide increasing the production of insulin in the pancreas - your doctor may prescribe them to more effectively lower your blood sugar levels.

How long does Gliclazide stay in your system?

There are many factors which affect how long a drug will remain in your system, such as the rate of your own metabolism, the amount of the drug you ingest and whether the medicine is formulated to be short-acting or long-acting.


Sources

NHS, 2019. Gliclazide.

NICE/BNF. Gliclazide

Treatment information

  • Product Name: Gliclazide
  • Manufacturer: Accord
  • Active Ingredient(s): Gliclazide
  • Administration: Oral
  • Presentation: Film-coated tablets
  • Available Strength: 30mg, 40mg, 60mg, 80mg
  • Exemption: Prescription only
  • Dosage: Take as prescribed by your doctor
  • Description: Gliclazide is a treatment for type 2 diabetes which increases the production of insulin to lower blood sugar levels
  • Drug Class: Sulphonylurea
  • Alcohol Consumption: Avoid or limit alcohol consumption
  • When Pregnant: Do not take Gliclazide if you are pregnant or plan on becoming pregnant. Speak to your doctor for further advice.
  • When Breastfeeding: Do not take Gliclazide while breastfeeding. Speak to your doctor for further advice.
  • Related Drug:
Click here to view the Gliclazide - Patient Information Leaflet

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