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Komboglyze

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Reviews
About Product
Mohamed Imran Lakhi
This content has been written and checked for quality and accuracy by
Mohamed Imran Lakhi Content Administrator Updated on: 08/12/2021 Next review: 08/06/2022

What is Komboglyze?

Komboglyze is an oral anti-diabetic prescription-only medication and is one of several diabetic medications available for purchase online to treat type 2 diabetes in adults.

The two active ingredients are: Saxagliptin, a DPP-4 inhibitor (dipeptidyl peptidase-4 inhibitor), and metformin, a 'biguanide' medication. Komboglyze is effective for people whose diabetes cannot be effectively controlled by metformin alone.

Komboglyze is only available on prescription. However, you can get a private prescription for Komboglyze online from Prescription Doctor. Simply complete our online medical form for one of our doctors to review.

If your order is approved by our doctor before 3pm on a weekday, our UK pharmacy can dispatch your item the same day via a discreet next-day delivery.


How does Komboglyze work?

Komboglyze controls your blood sugar by increasing insulin levels after a meal.

It also lowers glucose that the body makes. It helps to reduce your blood sugar, along with diet and exercise.

Your doctor may prescribe Komboglyze on its own or alongside other anti-diabetic treatments.

How long does Komboglyze take to work?

While Komboglyze starts working within a few hours, it may take a few days or weeks for your blood sugar levels to stay within the normal ranges.


How do I take Komboglyze?

Always take Komboglyze as prescribed by your doctor.

Take one tablet twice a day.

Swallow Komboglyze tablets whole with a glass of water.

Komboglyze tablets should be taken with a meal.

Do not crush or chew Komboglyze tablets.

Your doctor may change your dosage throughout your course of treatment.

Follow a healthy lifestyle, exercise and any specific dietary advice your medical practitioner has provided.

What should I do if I forget to take Komboglyze when I should?

Take the missed dose as soon as you remember. If it is nearly time for the next dose, skip the missed dose and continue taking your medicine as before. Never take more medicine to make up for the missed dose.

It is important to take the medicine at the same time each day.

What should I do if I take too much Komboglyze?

If you accidentally take too much Komboglyze, speak to a doctor immediately or go straight to a hospital, taking the medication pack with you.


Side effects and cautions

All medicines can cause side effects, though they are not guaranteed. Being aware of the risks associated with the medicine you are taking is important when undergoing treatment. We encourage you to familiarise yourself with the information presented in the patient information leaflet, which comes enclosed with your medicine, before you start taking it.

Common side effects (may affect up to 1 in 10 people):

  • Being sick or indigestion (dyspepsia)
  • Dizziness
  • Flatulence
  • Headache
  • Infection of the upper airways
  • Infection of your sinuses, sometimes with a feeling of pain or fullness behind your cheeks and eyes (sinusitis)
  • Inflamed stomach (gastritis) or gut, sometimes caused by an infection (gastro-enteritis)
  • Muscle pain (myalgia)
  • Tiredness (fatigue)
  • Urinary tract infection

Uncommon side effects (may affect up to 1 in 100 people):

This is not an exhaustive list of side effects. For more information regarding the safety of this medication, please read the enclosed patient information leaflet. You can read the patient information leaflet for Komboglyze online.

If you experience any side effects after taking Komboglyze, regardless of whether they are listed above or in the patient information leaflet, inform your doctor or speak to a pharmacist.

Allergies

Do not take Komboglyze if you are allergic to saxagliptin, metformin, or any of the other ingredients listed within the patient information leaflet.

If you experience the signs and symptoms of an allergic reaction after taking Komboglyze, stop taking the medicine and inform your doctor right away. In the case of a severe allergic reaction, go straight to your nearest accident and emergency department. Remember to take the packaging and any remaining medicine with you, so that doctors treating you know exactly what you took.

Pregnancy and breastfeeding

Do not take Komboglyze if you are pregnant, think you might be pregnant, or breastfeeding.

If you become pregnant while taking Komboglyze, inform your doctor right away.

Speak to your doctor for further advice and information.

Other cautions

Always read the provided patient information leaflet before you start taking Komboglyze.

Never take Komboglyze past the expiry date printed on the packaging. The expiry date refers to the last day of that month, for example "03/25" would be the 31st of March 2025.

Do not dispose of unused, unwanted or expired medication via general household or water waste. Take any unused, unwanted or expired medicine to your local pharmacy, who will be able to dispose of it safely on your behalf.

Always store medicine out of the sight and reach of children and pets.

Never share a medicine that has been prescribed to you with anybody else. Even if they are experiencing the same symptoms or have been diagnosed with the same condition.


Frequently Asked Questions

Can I drink alcohol while taking Komboglyze?

Avoid large amounts of alcohol with Komboglyze, due to the risk of lactic acidosis.  Symptoms can include feeling sick, vomiting, stomach ache, muscle cramps, generally feeling unwell with extreme tiredness and breathing difficulties.

You may experience reduced heartbeat and body temperature. As lactic acidosis can lead to coma, immediate hospital treatment may be needed. Discontinue the medication and contact a doctor or hospital. Take the medication pack with you.

Will Komboglyze impact my ability to drive or operate machinery?

Komboglyze's ingredients have a negligible influence in this regard. Hypoglycaemia could affect your driving ability and working with machinery, and Komboglyze combined with other medications, such as insulin or Sulphonylurea, can cause hypoglycaemia.

Will Komboglyze affect my contraception?

Komboglyze should not interfere with your contraception, including the combined contraceptive pill or the morning after pill.

If Komboglyze causes you to vomit or experience diarrhoea, your contraceptive may be affected. Consult the patient information leaflet for your contraceptive to see what to do in the case of diarrhoea or vomiting.

Can I buy Komboglyze online?

Yes, you can safely buy Komboglyze online from a registered pharmacy, such as Prescription Doctor. To begin your order, simply fill out our short medical questionnaire and our doctor will review your order. If your order is approved before 3pm, our UK based pharmacy will dispense and dispatch your item via a next-day discreet delivery service.


Sources

AstraZeneca, 2021. Komboglyze: Summary of Product Characteristics.

NHS, 2019. Saxagliptin.

Treatment information

  • Product Name: Komboglyze
  • Manufacturer: AstraZeneca
  • Active Ingredient(s): Metformin hydrochloride and Saxagliptin hydrochloride
  • Administration: Oral
  • Presentation: Film-coated tablets
  • Available Strength: 2.5mg/850mg and 2.5mg/1000mg
  • Exemption: Prescription only
  • Dosage: Take 1 tablet twice daily with food
  • Description: Komboglyze is a combined treatment for type 2 diabetes which contains Metformin and Saxagliptin.
  • Drug Class: Antihyperglycaemic
  • Alcohol Consumption: Avoid or limit alcohol consumption
  • When Pregnant: Do not take Komboglyze during pregnancy. Speak to your doctor for further advice.
  • When Breastfeeding: Do not take Komboglyze while breastfeeding. Speak to your doctor for further advice.
Click here to view the Komboglyze - Patient Information Leaflet

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