Gepretix

In Stock

Prices from £26.99
Review More Prices

Get Started
You must complete a short online consultation so that our prescriber can ensure that the treatment is suitable for you.
Order now to receive your order Tuesday, September 15
All inclusive service
No hidden fees
Next day delivery
Discreetly packaged
Discreet delivery
Prescriber available
Prescriber assess you online
How to order
  1. Click on the green "Get Started" button, then click "Start Consultation" button on the next page.
  2. Fill in our short consultation form.
  3. Choose delivery method and mode of payment.
  4. Our team of expert prescribers will assess whether medication is suitable.
  5. If you get the green light and it is deemed suitable, your order will be processed quickly and efficiently.
Confidential Service

Your privacy is important, Prescription Doctor are committed to keeping your details completely confidential.

This is why we also take steps to conceal your prescription products under two layers of packaging.

Delivery and Packing
Discreet Delivery?

We have a commitment to delivering a discreet service and understand your need for privacy. We ship all orders via a trackable courier using discreet, plain packaging.

Do I Need to Wait in All Day for Delivery?

Once your order is dispatched you will receive a tracking number via sms and email.

Do You Deliver on Weekends?

We deliver medications between Monday and Saturday. You can upgrade to Saturday delivery on Friday.

My Order Hasn’t Arrived What Should I Do?

You should receive a tracking number with your order which you can use this number to track your parcel online. This should give you a clear indication of where your parcel is. If you haven’t received your parcel in the time frame given by our couriers, contact your local depot to find out where it is. You can also contact our support team who will do this for you.

Can I Be Notified by Text?

On checkout you will be asked to leave your mobile number so our courier can text you about the delivery. This is also useful if the courier has problems finding your address. We will not use your mobile number for anything else.

Payment Methods
How Can I Pay for My Order?

You can pay for your order using credit, debit card or via bank transfer.

I Don’t Have a Credit Card, How Can I Pay?

If you don’t have a credit or debit card you can pay via bank transfer. We will give you a unique reference number at checkout along with details of how to make the transfer. Once the money has cleared in our account, we will process your order.

How Do You Keep My Details Safe?

We are a completely secure site and take many measures to ensure your details are kept safe. We understand that you have a right to extreme privacy when purchasing sensitive health medications. All information that you provide to us is stored on our secure servers. Any payment transactions will be encrypted using SSL technology.

Payment and refunds?

You can pay for your order using credit, debit card and bank transfer.

Card Payment: Please notify us that you wish to cancel your order. Your refund will show available In 1 - 3 days.

Bank Transfer: A member of our team will contact you requesting for your bank details. These details are only used to transfer the funds back into your account.

Treatment Information

Table of contents:

What is Gepretix?

Gepretix is a prescription-only medicine containing micronised progesterone, a natural form of the female hormone progesterone. It is available as Gepretix 100 mg and Gepretix 200 mg soft capsules and is used as part of hormone replacement therapy (HRT) in post-menopausal women who still have a womb (intact uterus).

Gepretix is taken alongside an oestrogen medicine to protect the lining of the womb from the effects of oestrogen taken alone. It is not a contraceptive and is not suitable for use during pregnancy or breastfeeding.

How Does Gepretix HRT Work?

Oestrogen is a central part of HRT and helps relieve common menopausal symptoms such as hot flushes, night sweats and vaginal dryness. However, in women who still have a womb, taking oestrogen without a progestogen causes the lining of the womb (the endometrium) to thicken excessively over time. This can increase the risk of endometrial (womb) cancer.

Gepretix works by counteracting this effect. As a natural progestogen, it acts on the endometrium, shifting it from the growing (proliferative) phase to the secretory phase and stabilising and protecting the womb lining.

As Gepretix contains micronised progesterone that is chemically identical to the progesterone your body produces naturally, many people prefer it to synthetic progestogens. It also has mild anti-oestrogenic, anti-androgenic and anti-aldosterone properties. These all contribute to its overall hormonal effects within your body.

How Long Does Gepretix Take to Work?

Gepretix begins protecting the endometrium (womb lining) from the first cycle you take it alongside an oestrogen product as part of HRT. It’s important to remember that you won’t be taking Gepretix without an oestrogen component, and the menopausal symptom relief is primarily driven by the oestrogen medication. You may notice symptom improvement within a few weeks of starting HRT, but it may take up to 3 months to see its full effects. 

How Effective is Gepretix HRT?

Various clinical studies support Gepretix's effectiveness as part of combined HRT by examining protection of the endometrium (inner lining of the womb), breast tolerability, and cardiovascular safety.

A multicentre, randomised, double-blind, placebo-controlled trial in 875 post-menopausal women over three years discovered these key findings:

The trial design reduced the risk of bias, increasing the reliability of findings.

Meanwhile, a French prospective study in over 80,000 women found that HRT using natural progesterone was associated with a significantly lower risk of breast cancer compared to some synthetic progestogens, with a risk profile closer to that of non-HRT users. Finally, in a third case-control study, oral micronised progesterone was associated with a lower risk of venous thromboembolism (blood clots) compared with some synthetic progestogens.

Altogether, these studies support Gepretix as a well-evidenced component of combined HRT, with a hormonal profile that may offer advantages over some synthetic alternatives in terms of tolerability and safety.

How to Take Gepretix Capsules

Take your Gepretix capsule by mouth at bedtime, as directed by your prescriber. Your prescriber will prescribe the lowest possible dose to treat your symptoms effectively for as short a time as necessary. Take it on an empty stomach, as food increases the amount of medicine your body absorbs and may intensify side effects such as drowsiness or dizziness.

Swallow the capsule whole with a glass of water. Your prescriber will advise you on when in your monthly cycle to take Gepretix, as this depends on the type of oestrogen HRT you are using. Take your oestrogen HRT at the same time as Gepretix. You should continue to take your oestrogen HRT every day, following your prescriber’s advice.

After you have completed the Gepretix-taking phase of your monthly cycle, you will usually have a few days of withdrawal bleeding. If you have a problem with this bleed, your prescriber may change the way you take Gepretix. 

Gepretix Dosage Information 

The usual dose is 200 mg taken once daily at bedtime for twelve consecutive days per cycle, typically from Day 15 to Day 26. Alternatively, your prescriber may recommend 100 mg taken daily from Day 1 to Day 25 of each cycle. This method can lead to less withdrawal bleeding. Your prescriber will determine the most appropriate dose and schedule for you.

If You Forget to Take Gepretix HRT

If you forget to take Gepretix as normal, take it as soon as you remember. If it’s nearly time for your next dose, skip the missed one and take the next at the regular time. Do not try to take a double dose to make up for a forgotten one. 

If You Take Too Many Gepretix Capsules 

If you take more Gepretix than you should, speak to a clinician or go to a hospital. Remember to take the medicine pack (containing the Patient Information Leaflet) with you to the hospital. You may experience adverse reactions such as drowsiness, sleepiness, tiredness, or dizziness. 

Gepretix Side Effects and Cautions

Before taking Gepretix, it’s important that you are aware of potential side effects and risks associated with treatment. Some risks are associated with HRT in general and are often driven by the oestrogen component. This information will cover the listed side effects of Gepretix, as well as other potential risks of HRT use. 

Side Effects of Gepretix HRT

Not everyone who takes Gepretix will experience side effects. The frequency of side effects is not reported in the patient information leaflet; however, certain effects have been noted in clinical trials and with prescribed use:

 

Reported Side Effects

(frequency unknown)

Observed in Clinical Trials

(frequency unknown)

  • Stomach pain
  • Nausea
  • Tiredness
  • Headache
  • Drowsiness
  • Dizziness
  • Vaginal bleeding
  • Intense itching
  • Stomach bloating
  • Depression
  • Breast tenderness
  • Hot flashes
  • Vaginal discharge
  • Joint pain
  • Urinary problems 

 

This is not an exhaustive list of potential side effects of Gepretix. More information, including a detailed breakdown of potentially serious risks of HRT use, is available in the Patient Information Leaflet that comes with the medication. If you do experience any adverse reactions to the treatment, you can also report them using the MHRA’s Yellow Card Scheme.

Possible Side Effects From HRTs

Further side effects have been reported by women who use HRT. These side effects may not occur as a direct result of Gepretix use, but you should still be aware of them before commencing HRT:

  • Gallbladder disease
  • Various skin disorders and rashes (chloasma, melasma, urticaria, erythema nodosum, and erythema multiforme)
  • Breast pain
  • Fluid retention (oedema)
  • Weight changes
  • Increase or decrease in sexual desire
  • Depression
  • Fever
  • Insomnia 
  • Alopecia (hair loss)
  • Irregular menstruation
  • Lack of menstruation

Information regarding serious risks associated with HRT is discussed in the section “Gepretix Warnings and Interactions”.

Gepretix Warnings and Interactions

Gepretix is prescribed for post-menopausal women who still have a womb and are taking oestrogen as part of HRT. It is not suitable for women who:

  • Are allergic to progesterone or any other ingredient of this medicine (this includes soya bean and peanut)
  • Have ever had breast cancer or if you suspect you may have it 
  • Have a cancer that is sensitive to oestrogens (e.g. endometrial) or are suspected of having it 
  • Have any unexplained vaginal bleeding 
  • Have or have ever had a blood clot in a vein (e.g. deep vein thrombosis or pulmonary embolism)
  • Have a blood clotting disorder
  • Have or recently have had a disease caused by blood clots in the arteries (e.g. stroke, heart attack, or angina)
  • Have or have ever had a liver disease and your liver function tests have not returned to normal 
  • Have a rare blood disorder called porphyria
  • Have bleeding in the brain (cerebral haemorrhage) 
  • Are breastfeeding

If any of these conditions appear for the first time whilst taking Gepretix, stop taking it and contact your doctor. You should undergo regular medical checkups whilst taking HRT. 

Precautions Before Taking Gepretix

You must tell your prescriber before taking Gepretix if any of the following apply to you, as they may return or become worse during treatment with HRT:

  • Abnormal tumours/growths (fibroids inside your womb)
  • Growth of womb lining outside your womb (endometriosis) or a history of excessive growth of the womb lining (endometrial hyperplasia)
  • Increased risk of developing blood clots
  • Increased risk of getting an oestrogen-sensitive cancer (such as having a mother, sister or grandmother who has had breast cancer)
  • High blood pressure
  • Liver problems such as a benign tumour
  • Diabetes
  • Gallstones
  • Migraine or severe headaches
  • A disease of the immune system that affects many organs of the body (systemic lupus erythematosus, SLE)
  • Epilepsy
  • Asthma
  • A disease affecting the eardrum and hearing (otosclerosis)
  • You have ever had depression
  • Your skin is sensitive to light (photosensitivity)

Your prescriber will assess the benefits and risks of taking HRT, ensuring you are informed about your options.

When to Stop Taking Gepretix 

If you notice any of the following whilst taking Gepretix, stop taking it and seek immediate advice from your doctor:

  • Any condition listed in the “DO NOT take Gepretix” section of the patient information leaflet
  • Yellowing of your skin or the whites of your eyes (jaundice). These may be signs of a liver disease
  • A large rise in your blood pressure (symptoms may be headache, tiredness, dizziness)
  • Migraine-like headaches which happen for the first time
  • Sudden or gradual, partial or complete loss of vision
  • Proptosis (forward displacement of the eye) or diplopia (double vision)
  • Swelling of the optic nerve (papilloedema)
  • Eye diseases (retinal vascular lesions)
  • If you become pregnant
  • If you notice signs of a blood clot, such as painful swelling and redness of the legs, sudden chest pain, or difficulty in breathing

HRT Risk Information 

HRT can provide significant relief for those struggling with the symptoms of the menopause. However, taking HRT can increase your risk of certain serious conditions. A full breakdown of the risk information is available in the Patient Information Leaflet contained within the medicine package.

Oestrogen HRT thickens the lining of the womb and can increase your risk of endometrial cancer. Gepretix is designed to protect you from this extra risk. You will have a monthly withdrawal bleed whilst taking Gepretix. If you experience bleeding or spotting besides your monthly bleeding which carries on after 6 months of taking Gepretix, starts after 6 months of taking it, or carries on after you have stopped taking it, see your doctor as soon as possible.

Taking HRT has also been linked to an increased risk of breast cancer. You should check your breasts regularly and see your doctor if you notice any changes. Taking HRT has also been associated with a slightly increased risk of ovarian cancer. Ovarian cancer is much rarer than breast cancer.

The risk of blood clots in the veins is 1.3 to 3 times higher in women who take HRT (especially during the first year of taking it). The patient information leaflet lists risk factors and symptoms of a blood clot that you should be aware of. Women over 60 who use oestrogen-progestogen HRT are slightly more likely to develop heart disease. HRT users also have about a 1.5 times higher risk of stroke. There is evidence of a higher risk of memory loss in women who start HRT after the age of 65.

Overall, you should speak to your doctor about the benefits and risks of HRT. They will help you to assess your individual risk factors and suitability for HRT. If you notice any signs of a serious condition whilst taking HRT, you should see your doctor immediately. 

Gepretix and Other Medicines

Tell your prescriber if you are currently taking or have recently taken any other prescribed medicines, over-the-counter medications, herbal remedies, or supplements. Gepretix can affect the way some medicines work and other medicines may interfere with the effect of Gepretix:

  • Medicines for epilepsy (such as phenobarbital, phenytoin and carbamazepine)
  • Medicines for tuberculosis (such as rifampicin, rifabutin)
  • Medicines for HIV infection (such as nevirapine, efavirenz, ritonavir and nelfinavir)
  • Herbal remedies containing St John’s Wort 
  • Bromocriptine
  • Cyclosporin 
  • Ketoconazole
  • Spironolactone
  • Antibiotics (ampicillins, tetracyclines)
  • Antisteroids (medroxyprogesterone acetate, megestrol)
  • Medicines to prevent blood clots (such as coumarins, phenindione)
  • Diabetic medicines
  • Emergency contraceptives (ulipristal acetate)
  • Diazepam
  • Tizanidine

Pregnancy and Breastfeeding 

Gepretix is for use by post-menopausal women only. Do not take Gepretix if you are pregnant or may become pregnant. If you do become pregnant, stop taking Gepretix and contact your doctor immediately. You must talk to your doctor before taking this medicine if you are breastfeeding. 

Frequently Asked Questions About Gepretix HRT

Gepretix vs Utrogestan: What’s the Difference?

Gepretix and Utrogestan both contain micronised progesterone and are used in the same way as part of HRT to protect the womb lining in post-menopausal women. Although the active medication is the same, the capsules contain different ingredients (be aware of this if you have certain product allergies).

Utrogestan has been available in the UK for longer, while Gepretix is a newer alternative. Your prescriber may switch between them based on availability. Utrogestan is only available in 100 mg oral capsules.

Is Gepretix Body Identical?

Gepretix contains micronised progesterone, which is chemically identical to the progesterone your body produces naturally. For this reason, it is sometimes described as a "body-identical" hormone. This helps distinguish it from synthetic progestogens such as norethisterone or medroxyprogesterone acetate, which have different chemical structures and behave differently in the body.

Does Gepretix Cause Weight Gain?

Weight gain is not a commonly reported side effect of Gepretix. The PEPI trial, which studied 875 post-menopausal women over three years, did not identify weight gain as a significant finding in those taking micronised progesterone alongside oestrogen. It is also not listed as a potential side effect of the treatment in the Patient Information Leaflet.

Some women on HRT may experience fluid retention or bloating, particularly in the early weeks of treatment, but this is more commonly associated with oestrogen than with progesterone. If you notice changes in your weight during treatment, speak to your prescriber. They can help identify whether there is a hormonal cause and discuss adjustments to your regimen.

Can I Take Gepretix in the Morning?

Gepretix is taken at bedtime because micronised progesterone can cause drowsiness and dizziness within 1 to 3 hours after taking a dose. This is a recognised effect of natural progesterone on the central nervous system. Taking Gepretix at night means any sedative effects occur while you are sleeping rather than during the day.

You should avoid driving or operating machinery after taking it. If you experience residual drowsiness the following morning, speak to your prescriber, as a dose adjustment may help.

Can You Take Gepretix Vaginally?

No. Gepretix is licensed as an oral medication, meaning you take the capsule by mouth. Whilst there are some references online to taking progesterone vaginally, this is not licensed for HRT. Some prescribers may suggest using micronised progesterone off-label (in a way not generally approved but with evidence to support its use).

However, high-quality studies are still lacking to support vaginal use. Vaginal forms of progesterone (gels and capsules) are available but are used to treat other conditions, such as as part of fertility treatment (IVF). 

Can You Drink Alcohol with Gepretix Capsules?

There is no known significant interaction between alcohol and Gepretix. Equally, there is no major interaction between alcohol and the oestrogen component of HRT. This means you can drink in moderation whilst taking HRT. However, be aware that alcohol use may worsen some menopause symptoms (such as hot flushes) and can contribute towards the risk of some serious conditions when used in excess. The government recommends consuming no more than 14 units of alcohol a week. 

Can You Get Gepretix Over the Counter?

No. Gepretix is only available with a prescription from an appropriately trained prescriber. This applies to all systemic HRTs. These medicines are prescription-only to ensure safe use and that they are taken by individuals for whom the benefits outweigh the risks. Some low-dose oestrogen products that are used vaginally are available over the counter to treat vaginal dryness.

Can You Buy Gepretix Online?

Yes, you can buy Gepretix online from trusted pharmacies such as Prescription Doctor. There’s no need for an appointment or face-to-face consultation, just a straightforward form that our experienced clinicians can review to determine if the treatment is right for you.

All our licensed medications are dispatched from our General Pharmaceutical Council-registered pharmacy to your designated UK address in plain packaging for complete discretion. Orders approved before 3pm on a weekday are also eligible for next-day delivery. 

How Do I Store Gepretix Capsules?

Keep Gepretix capsules out of sight and reach of children. Do not store above 30°C and do not use after the expiry date printed on the carton. Do not dispose via household waste or wastewater. Ask your local pharmacist for advice on disposing of medications. 

Additional Resources

PAGE

What are the 34 symptoms of the menopause?

Menopause is a pivotal event in women’s lives, due to its wide-reaching impact and the significant changes involved. If you’re approaching menopause or would like to better understand what to expect, researching potential symptoms is crucial. While not everyone might experience the same things, it’s still worth finding out as much information as possible.In this article, we’ll answer important questions such as “Am I going through menopause?” and “What are the 34 symptoms of menopause?”, as well as discuss some early signs to be aware of and explore the different medications you can take. Let’s begin.  [medical_form product_id="471" text="START YOUR MENOPAUSE CONSULTATION TODAY" type="button"] What Does Menopause Mean?Menopause is a natural part of the female ageing process and describes the stage in a woman’s life when her periods stop. This change is permanent, and women can no longer get pregnant after menopause. The time leading up to menopause is called perimenopause, or the menopausal transition.Some women experience a variety of menopausal symptoms, while others have mild symptoms or none at all. Many people consider the perimenopausal stage part of menopause, but true menopause isn’t confirmed until at least one year has passed since a woman’s last period.At What Age Does Menopause Begin?Menopause usually begins between the ages of 45 and 55. However, it can happen earlier than this and may not be age-related. Premature menopause, defined as occurring before the age of 40, and early menopause, which affects women from 40 to 44, have several possible causes.For example, some women experience early menopause because of surgeries that remove the womb (hysterectomy) or ovaries (oophorectomy). Early menopause may also be triggered by chemotherapy or genetic factors. Other potential contributors to premature and early menopause include:SmokingHigh blood pressureThyroid disease  What are the 1st Signs of Menopause?Menopause symptoms can vary significantly between women, making it harder to establish when the menopausal transition has begun. However, the early signs of menopause commonly include:Changes in the regularity of periodsHot flashesNight sweatsBladder incontinenceSleep problemsVaginal drynessMood changesBrain fogNot all women experience menopause symptoms, but around 75% have them to some degree. For some women, these symptoms are mild and can be managed with small lifestyle adjustments, while for others, they are more severe. The symptoms of menopause last an average of 7 years, though they can continue for over 10 years in some women.What are the 34 Symptoms of Menopause?The symptoms of menopause are diverse, and not every woman has the same experience. There are around 34 menopause symptoms, ranging from physical issues (like hot flashes and headaches) to emotional and cognitive problems (such as mood swings and memory loss). {add_product_block(471)} 1. Hot FlashesHot flashes, the most common type of menopause vasomotor symptom, are sudden, short bursts of heat that cause redness and flushing around the face, neck and chest. This can be very uncomfortable, and some women find hot flashes disrupt their daily lives. For some people, small changes in their daily routine can help manage hot flashes. However, others may require hormonal or non-hormonal medications to reduce their symptoms.2. Period ChangesChanges in periods are a common sign of perimenopause and a result of fluctuating hormone levels. As women enter the menopausal transition, their ovaries start producing different amounts of oestrogen and progesterone, which play key roles in regulating menstruation.Your periods may become less regular, with cycles that are heavier, lighter, longer, or shorter than they used to be. Some women have periods that occur very close together, while others may skip a few months. Irregular periods continue for 2-8 years before stopping altogether.  3. Night SweatsHot flashes that happen at night are called night sweats. Some women with night sweats wake frequently, which can significantly disrupt sleep. It may be possible to manage night sweats with small dietary and lifestyle changes, or with prescription hormonal or non-hormonal medication.4. Poor Sleep QualityPoor sleep quality is a common issue for women experiencing menopausal transition. Many symptoms, such as night sweats and mood changes, can interrupt sleep and contribute to chronic sleep problems, like insomnia. Developing healthier sleep habits may help to improve sleep quality, as can medications like melatonin.5. Heart Palpitations Heart palpitations (which are rapid, irregular, or exaggerated heartbeats) affect up to 42% of perimenopausal women and 54% of postmenopausal women. This is another example of a vasomotor symptom, and studies have shown that cognitive behavioural therapy (CBT) can improve palpitations, night sweats, and hot flashes. Maintaining a healthy diet, frequent exercise, managing anxiety, and avoiding alcohol may also help to reduce heart palpitations.6. HeadachesHeadaches and migraines can change in severity and frequency during menopause. For some women, migraine symptoms worsen during the menopausal transition, possibly as a result of fluctuating oestrogen levels. Other types of headaches (like cluster and tension headaches) may also increase during menopause.   7. Mood SwingsMenopause is often associated with sudden mood swings, which can cause intense and unpredictable shifts in emotional state. Other mental health problems that can flare up during menopause include anxiety, depression, and stress. Alterations to mental well-being can happen because of changing hormone levels, but can also be exacerbated by sleep problems.8. Vaginal DrynessHormone fluctuations during the menopausal transition can bring about physical changes in the vagina. The inner lining of the vagina can become thinner, causing symptoms like vaginal dryness, burning, itching, and irritation. Genitourinary symptoms (i.e., symptoms affecting the genitals and urinary tract) affect an estimated 50-75% of women going through menopause.9. Memory LossMany menopausal women experience memory issues and brain fog, possibly because of declining oestrogen levels. This affects several aspects of cognitive function, including working memory, attention, processing speed, and verbal memory. Fortunately, many women find their memory problems improve after menopause, once their hormone levels stop fluctuating.10. TirednessSleep problems and hormonal fluctuations during the menopausal transition leave many women feeling fatigued. One study found that 46.5% of perimenopausal women and 85.3% of post-menopausal women felt physically and mentally exhausted, compared with just 19.7% of pre-menopausal women.  11. Loss of Sex DriveLoss of sex drive is common during menopause, as declining hormone levels can reduce libido. It may take longer to become aroused, and vaginal dryness can make sex uncomfortable or even painful. Other menopause symptoms, like poor sleep quality and mood changes, can also contribute to a lack of interest in sex.12. DepressionMenopause can increase your risk of depression, with one large study reporting rates of 35.6% among menopausal women. Doctors think this is due to changes in hormone levels, which have been associated with depression, irritability, and anxiety. Women who experience vasomotor symptoms (like hot flashes and sleep problems) are more likely to develop depression during menopause.13. AnxietyThe fluctuating hormone levels that characterise menopause may affect serotonin and Gamma-Aminobutyric Acid (GABA) signalling in the brain. This can contribute to mood changes during menopause, including depression and anxiety. Other menopause symptoms, like lack of sleep, can further exacerbate anxiety.14. Weight GainMany women gain weight during the menopausal transition. Weight gain often begins a few years before menopause and continues at about 1.5 pounds per year. However, hormonal changes alone don’t cause weight gain, and it’s usually due to a combination of factors, including ageing, lifestyle, and genetics. If you'd like to know more about losing weight during the menopause, please read our dedicated article.   15. Joint PainsJoint pain affects more than half of women going through menopause, as declining oestrogen levels can increase inflammation in the joints. Low oestrogen levels can also weaken muscle and bone, increasing the risk of osteoarthritis. You may be able to improve joint health and limit pain with low-impact exercise, strength training, and daily stretching.16. Poor ConcentrationPoor concentration, or ‘brain fog,’ affects many women experiencing menopausal transition. Oestrogen has neuroprotective effects, so declining levels may contribute to cognitive issues. Other menopause symptoms, like poor sleep quality and depression, can also impair concentration.17. Hair LossMenopause can cause changes to hair, as low oestrogen levels can impact the health of hair follicles. This may lead to thinning, loss of volume, and changes in hair texture. This phenomenon, called female pattern hair loss, may affect up to 56% of post-menopausal women.18. DizzinessDizziness is one of the most common symptoms of menopause, with 35.7% of women experiencing this symptom weekly. This may be linked to other menopause symptoms, such as anxiety and hot flashes. 19. Urinary Tract InfectionsUrinary tract infections are common among women in all life stages, but their prevalence increases after menopause. This may be because lower oestrogen levels impact the health and function of the vaginal mucosal wall. Thinning of the vaginal wall, impaired immune function and changes in the vaginal microbiota can all increase the risk of UTIs.  20. BloatingMany women experience digestive symptoms during menopause, including acid reflux, abdominal pain, bloating, constipation, and diarrhoea. Bloating is the most common of these symptoms, affecting an estimated 77% of menopausal women. Bloating is caused by a build-up of gas and is often linked to hormonal changes.21. Taste ChangesMenopause can alter taste perception, with some women reporting a reduction in the intensity of sweet and bitter flavours. This effect may have multiple causes, but it is linked to hormonal fluctuations and decreased salivary production during menopause.22. Urinary IncontinenceUrinary incontinence affects over 50% of post-menopausal women and is the most common symptom of Genitourinary Syndrome of Menopause (GSM), a cluster of conditions affecting the genitals and urinary tract. Declining estrogen levels can weaken urogenital tissues, including those supporting the bladder, and lead to urinary urgency and incontinence.23. Digestive IssuesDigestive problems such as diarrhoea, constipation, nausea, vomiting, abdominal pain, bloating, heartburn, and faecal incontinence may be more prevalent among menopausal women than pre-menopausal women. Oestrogen and progesterone play key roles in gastrointestinal health, so declining hormone levels may contribute to digestive issues in menopausal women.24. Muscle StrainMenopause has a profound effect on musculoskeletal health, and more than 70% of menopausal women report musculoskeletal symptoms like muscle strain. Researchers believe that reduced oestrogen levels can lead to a loss of muscle and bone mass, contributing to conditions that affect these tissues. {add_product_block(304)} 25. Dry & Itchy SkinHormonal changes during menopause can make skin thinner and drier.  This is because oestrogen supports skin health, and declining levels can contribute to dryness, which leaves skin feeling tight, flaky, and itchy.26. Change in Body OdourMany women find that their body odour gets stronger during menopause. This may be because a drop in oestrogen levels leaves the body with a relatively higher testosterone level, which can alter the skin's bacterial population. It may attract more bacteria, making sweat smell even stronger. Hot flashes and night sweats can also increase the number of bacteria in the armpits, further contributing to body odour.27. Brittle NailsChanges in oestrogen levels during menopause can affect nail health, making nails more brittle. This is because drops in oestrogen weaken the keratin layers in fingernails, causing them to break more easily. Dehydration can further weaken keratin and contribute to nail breakage, peeling, cracks and splits.28. AllergiesHormonal fluctuations women experience during menopause may contribute to the development of allergies. A reduction in oestrogen levels during menopause can also exacerbate asthma symptoms or lead to the development of asthma in women who didn’t previously have the condition.  29. Electric Shocks Under the SkinDeclining hormone levels during menopause can cause neurological symptoms and odd sensations. These can manifest as electric-shock sensations, which feel like sudden jolts or zaps under the skin. Many women also report experiencing paresthesia, or pins and needles.30. Breast TendernessBreast pain, or mastalgia, affects up to 70% of women and is a common symptom of menopause. Hormonal changes can cause breasts to feel more tender than usual, and they may feel lumpier than they did before. These symptoms often resolve after menopause, when hormone levels drop.31. TinnitusAlmost one-third of women experience new or worsening tinnitus during menopause, and doctors believe declining oestrogen levels are the cause. Oestrogen supports ear health, so having less of it can contribute to tinnitus. Other symptoms like anxiety, lack of sleep, and depression can also make tinnitus worse during menopause.32. Tingling Sensation in ExtremitiesHormonal changes during menopause can manifest as neurological symptoms, including paresthesia - an abnormal tingling or prickling sensation also known as ‘pins and needles.’ Many women experience this sensation in their hands and feet during menopause, though it is usually short-lived.33. OsteoporosisOsteoporosis is a serious medical condition that weakens bones to the point that they become fragile and break easily. The risk of osteoporosis increases with age, but menopausal women are more likely to develop the disease than men. This is because bone mass decreases around menopause, and women may lose up to 10% of their bone density in the 5 years after their periods stop. {add_product_block(453)} 34. Bleeding GumsFluctuating hormone levels can contribute to oral health problems, including dry mouth (xerostomia), gum disease, burning mouth syndrome (BMS), and changes in taste perception. Gum disease can cause gums to bleed, especially when brushing or flossing.How to Manage the Symptoms of MenopauseMost symptoms of menopause are related to natural ageing and the low levels of sex hormones (oestrogen, progesterone and testosterone) a woman produces, as she reaches the menopause period of her life. However, there are several ways you can manage some of these symptoms during menopause, and they include:Hormone replacement therapy (HRT)Medications like antidepressants can help with mood and depression Using lubricants for vaginal dryness Taking calcium and vitamin D supplements to help with weak bones.Lifestyle changes like exercising and eating a healthy diet  A few years post menopause, most symptoms should reduce and eventually stop. However, you should speak to your GP about troublesome issues and discuss treatments to manage menopausal symptoms.What Medication Can I Take for the Menopause?Menopause can produce a wide variety of symptoms affecting many aspects of physical and mental health. Some women go through menopause with no noticeable symptoms, while others have mild symptoms that they can manage with simple lifestyle adjustments. However, a number of women experience severe symptoms that disrupt their daily lives and require medication to reduce their impact.Oestrogel: Oestrogel is a topical hormone replacement therapy (HRT) that contains estradiol (i.e., oestrogen) as its active ingredient. This can counter the drop in hormone levels associated with menopause and help to alleviate symptoms like headaches, hot flashes, mood swings, heart palpitations, and more.Utrogestan: Utrogestan is a form of progesterone HRT. It should be used alongside an oestrogen-based HRT and can help to improve menopause symptoms by compensating for declining hormone levels.Estradot: Estradot is an HRT transdermal patch that contains estradiol, the primary form of oestrogen. The patches can be worn twice weekly to relieve hot flashes and night sweats, mood swings, vaginal dryness, and sleep problems.Evorel: Evorel HRT patches contain synthetic hormones that mimic the effects of oestrogen and progesterone. Users can apply the patches twice a week to rebalance hormones and improve menopause symptoms.Bijuve: Bijuve is an HRT medication containing both oestrogen and progesterone. These daily capsules supplement low hormone levels in menopause to relieve symptoms, including hot flushes, irritability, joint pains, and more.The hormonal changes brought about by menopause can manifest in diverse symptoms affecting many aspects of women’s physical, mental, and cognitive health. Prescription Doctor has a wide range of medications that can help to improve symptoms and quality of life by mitigating the effects of low oestrogen and progesterone levels.Support at Every StepIf you think you may be going through menopause or require some more advice, Prescription Doctor is here to help. Our dedicated team is available to support you at every stage, to help make the process as stress-free as possible.We strive to facilitate access to healthcare and give patients more control over how they obtain treatment. With us, there’s no need for face-to-face appointments that can take several days to arrange. Instead, you can fill out our online consultation form from your own home at any time. This makes obtaining a menopause test kit or ordering medication much more straightforward.Once the form has been completed, our specialist clinicians will review your information and determine whether your order is suitable for your circumstances. All orders approved before 3pm on a weekday are eligible for next-day delivery, while everything we dispatch is stored in plain packaging for complete discretion.To find out more about how Prescription Doctor can help you, or to request treatment, complete our consultation form today.  SourcesNIH (2024): What Is Menopause?PubMed (2023): Age at Natural Menopause and Influencing Factors in Women Attending the Gynaecological Outpatient Clinic at a Tertiary Care Hospital. PubMed (2025): Trends in age at natural menopause and menarche and related factors in Iran: results from a population-based study. NHS (2022): Menopause. BBC News (2024): What is the menopause and what are the main symptoms?NIH (2023): Menopause. NHS: Menopause for partners. NIH (2021): Hot Flashes: What Can I Do?Office on Women’s Health (2025): Menopause basics. Mayo Clinic (2024): Menopause. NIH (2021): Sleep Problems and Menopause: What Can I Do?PubMed (2022): Correlates of palpitations during menopause: A scoping review. British Heart Foundation (2023): Menopause and your heart. NHS Inform (2022): Menopause and your mental wellbeing. PubMed (2018): The Dynamics of Stress and Fatigue across Menopause: Attractors, Coupling and Resilience. PubMed (2025): Cognitive Function in Peri- and Postmenopausal Women: Implications for Considering Iron Supplementation. BUPA (2025): Does the menopause cause memory loss? Office on Women’s Health (2025): Menopause and sexuality. ScienceDirect (2024): Global prevalence of depression in menopausal women: A systematic review and meta-analysis. PubMed (2023): Does menopause elevate the risk for developing depression and anxiety? Results from a systematic review. Mayo Clinic (2023): The reality of menopause weight gain. PubMed (2023): Arthralgia of menopause - A retrospective review. BUPA (2024): Are muscle aches and joint pains linked to the menopause?PubMed (2021): Menopause and cognitive impairment: A narrative review of current knowledge. PubMed (2023): The Menopausal Transition: Is the Hair Follicle “Going through Menopause”?NICE (2021): Female pattern hair loss (female androgenetic alopecia). PubMed (2018): Dizziness in peri- and postmenopausal women is associated with anxiety: a cross-sectional study. NHS (2022): Menopause Symptoms. PubMed (2025): Urinary tract infections after menopause. Women’s Health Concern (2025): Digestive health and menopause. PubMed (2024): Taste Changes and Salivary Flow Rate Disparities in Premenopausal and Postmenopausal Women: Exploring the Zinc Connection. PubMed (2019): Urinary incontinence in postmenopausal women – causes, symptoms, treatment. PubMed (2024): The Link Between Menopause and Urinary Incontinence: A Systematic Review. PubMed (2025): The volume and characteristics of research on gastrointestinal symptoms in ‘natural’ peri- and postmenopause: A scoping review. PubMed (2024): The musculoskeletal syndrome of menopause. NIH (2025): Skin Care and Ageing. PubMed (2019): Estrogen-deficient skin: The role of topical therapy. Harvard Health Publishing (2023): Why has my natural scent changed during perimenopause?Shropshire Council: Menopause symptoms and practical tips to manage them. PubMed (2024): The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults. PubMed (2015): Estrogen Signalling Modulates Allergic Inflammation and Contributes to Sex Differences in Asthma. PubMed (2023): Perimenopause as a neurological transition state. NIH (2025): Mastalgia. NIH (2024): Understanding Breast Changes and Conditions. UCI Health (2025): The surprising link between menopause and tinnitus. Tinnitus UK: Tinnitus and menopause. The Menopause Charity (2024): Join the dots: A-Z symptoms list.NIH (2022): Osteoporosis.  Victoria State Government: Menopause and osteoporosis. PubMed (2024): Menopause and Oral Health: Clinical Implications and Preventive Strategies. 
Read more →
What are the 34 symptoms of the menopause?
PAGE

10 Questions About the Menopause Answered

Menopause is a fact of life that many don't think about until they have to. Women in their reproductive years are often more concerned about birth control and STDs.Men don't experience menopause, although they do undergo similar age-related changes.In recent years, more women have started discussing menopause. Although they are more open about it, some are still left with questions.1.) What is the menopause?The menopause occurs in a woman after age-related declines in hormones cause her to stop menstruating. The main hormones that decline during menopause are oestrogen, progesterone and testosterone.A woman is considered to be fully in menopause after 12 months without menstruation. After this time, pregnancy is unlikely.2.) What age does the menopause hit?On average, women experience the menopause between the ages of 45 and 55. A woman may begin to experience fewer periods as she approaches menopause, or she may stop menstruating suddenly.One in 100 women hit menopause before age 40 - this is called premature menopause and is usually caused by ovarian failure, damage to the ovaries or surgical removal of the ovaries.3.) How long does the menopause last?On average, the menopause lasts about four years. The time leading up to menopause is called perimenopause, and the time after menopause is called post-menopause.Symptoms begin to develop during perimenopause and ease off during post-menopause.4.) What are the symptoms of the menopause?Some common symptoms are:changes in moodchillsdry skinhot flashesirregular periodsloss of breast fullnessnight sweatssleep problemsslow metabolism and weight gainthinning hairvaginal dryness5.) How is the menopause diagnosed?Doctors typically diagnose the menopause based on the description of the symptoms, though some women experience few symptoms.There are also home menopause test kits which can tell you if you are menopausal.6.) When is it safe to stop using contraceptive pills?The combined contraceptive pill can mask symptoms of the menopause, making it difficult to diagnose. Thus, it is recommended to stop taking combined contraceptive pills before the age of 50 and switch to another form of contraception, such as the progestogen-only pill, also known as the mini pill.Of course, condoms are the only contraceptive method which can prevent sexually transmitted diseases (STDs). They can be used after the menopause.7.) Can the menopause affect hair and skin?Yes. During the menopause, androgen levels increase. Androgens, such as testosterone, determine male characteristics, including facial and body hair. As a consequence, some women may notice an increase in unwanted facial and body hair.The drop in oestrogen and progesterone slows down hair growth, causing hair on the scalp to appear thin.Since the body stops making as much collagen during menopause, the skin loses elasticity and becomes dry. This can create sagging skin around the cheeks and jawline, as well as increase the appearance of wrinkles around the eyes.8.) Is it possible to delay the menopause?One study published in the Journal of Epidemiology and Community Health found that women who eat a diet rich in fish, legumes, beans, B12, and zinc reach menopause later than women whose diet contains simple carbohydrates, such as refined rice and pasta.Another US study showed that women who ate more low-fat milk products delayed menopause by over three and a half years. It's thought that enzymes in the cow milk could boost oestrogen levels.However, the findings of both studies only demonstrated a possible relationship between the factors, not a probable cause. That is to say that while diet may have an effect on the age at which women experience the menopause, there are several other factors to consider that could influence the cessation of the menstrual cycle, the primary indicator of menopause.9.) How does a partial hysterectomy affect the menopause?A partial hysterectomy removes just the womb, but the cervix and ovaries remain intact.Evidence indicates that women who undergo a partial hysterectomy are at an increased risk of ovarian failure and, hence, early menopause.It is not known if this is caused by the hysterectomy itself or another pre-existing cause.10.) Is there a cure for menopause?While there is no cure for the menopause, there are a variety of treatments to manage the symptoms.If you experience uncomfortable symptoms, there are treatments available to help manage them and bring relief.Hormone replacement therapy (HRT) is a common menopause treatment that's available online.After the menopause transition is complete, most symptoms either disappear or subside to a more manageable level. Women no longer have to worry about birth control or monthly menstrual cycles.They are now free to enjoy life on their own terms.
Read more →
10 Questions About the Menopause Answered

Treatment information

  • Product Name: Gepretix
  • Active Ingredient(s): Micronised progesterone
  • Administration: Oral
  • Presentation: Soft capsules
  • Exemption: Prescription Only
  • Application: For use alongside oestrogen in post-menopausal women with an intact uterus
  • Dosage: As prescribed.
  • Description: Gepretix is a progesterone medicine that is used alongside oestrogen as part of HRT.
  • Drug Class: Hormonal menopause treatment
  • Alcohol Consumption: No known interaction
  • When Pregnant: Do not take Gepretix
  • When Breastfeeding: Do not take Gepretix
Click here to view the Gepretix - Patient Information Leaflet

Authored & Reviewed By

Mohamed Imran Lakhi

Mohamed Imran Lakhi

MPharm - Lead Pharmacist
Imran Lakhi is the superintendent pharmacist and founder at Prescription Doctor. He has been at the core of our team.

Published on: 21/08/2026 Reviewed on: 21/08/2026

Menopause Alternatives

SELFCheck Menopause Test

SELFCheck Menopause Test

  • Fast results
  • Simple urine test
  • Dispatched from a UK pharmacy
View Treatment
Estradot

Estradot

  • Relieves hot flushes and night sweats
  • Transdermal patch worn twice weekly
  • Discreet and easy to use
View Treatment
Bijuve

Bijuve

  • Treats symptoms of the menopause
  • Available to re-order
  • Prescribed by a registered clinician
View Treatment
Veoza

Veoza

  • Treats symptoms of the menopause
  • Available to re-order
  • Prescribed by a registered clinician
View Treatment
Livial

Livial

  • Relieves postmenopausal symptoms
  • Available to re-order
  • Prescribed by a registered clinician
View Treatment
Customer Service