Estradot

About Estradot HRT Patches

Estradot patches are a twice-weekly, low-dose hormone replacement therapy (HRT) treatment designed to ease and manage uncomfortable menopause symptoms. Each patch delivers a steady dose of estradiol, a naturally occurring form of oestrogen, through your skin and into your bloodstream. The medication is suitable for women in both perimenopause and postmenopause.

Unlike tablets, which can be harder on digestion, Estradot patches are absorbed transdermally. This makes them a popular choice for women who want consistent relief without daily pills. Estradot comes in various strengths, allowing treatment to be tailored to your individual needs.

You can buy Estradot patches online from Prescription Doctor after completing a brief medical questionnaire. If approved by our clinicians, your order will be dispatched in plain and discreet packaging. Requests authorised by 3pm on a weekday are also eligible for next-day delivery. 
 

How Much Does Estradot Cost?

Prescription Doctor is pleased to offer Estradot HRT patches at the following prices: 

 We also provide a range of other menopause and HRT medications, such as Evorel, Novofem, Livial, and Bijuve. 

What is Estradot Used For?

Estradot is used as part of HRT to manage symptoms caused by declining oestrogen levels during menopause, perimenopause (the transition before periods stop completely) and postmenopause (when symptoms persist after menstruation has ended).

The patches are prescribed to relieve a wide range of common symptoms of menopause, including:

• Hot flushes and night sweats
• Mood changes, irritability or anxiety
• Sleep disturbances
• Vaginal dryness or discomfort during sex

Estradot 50, 75, and 100mcg patches can also be prescribed to help prevent osteoporosis in postmenopausal women who are at increased risk of fractures and cannot take other bone-strengthening treatments.

Estradot patches are an oestrogen-only HRT that can either be used on its own by women who have undergone a hysterectomy or in conjunction with a separate progesterone by those who still have their womb (or have been fitted with a Mirena coil). Prescription Doctor offers Utrogestan progesterone tablets, which can be used in combination with Estradot. 

How Do Estradot Patches Work?

Estradot patches work by replacing the oestrogen your body is no longer producing in sufficient amounts. The active ingredient, 17β-estradiol, is chemically identical to the main type of oestrogen produced in your ovaries before menopause. Once applied, estradiol is gradually released and absorbed through the skin. This helps to rebalance hormone levels, reducing the severity and frequency of menopause symptoms.

During the menopause, less and less oestrogen (the female sex hormone) is produced naturally by the body. This causes uncomfortable symptoms such as mood swings, hot flushes, insomnia, and excessive sweating. Estradot HRT patches are designed to combat this by releasing estradiol in the same manner as the ovaries do before menopause.

By restoring oestrogen, Estradot can also help support bone health and improve overall well-being during and after menopause. Oestrogen plays a vital role in maintaining bone density, so replacing it can help reduce the risk of osteoporosis and fractures. It can also have a positive effect on mood, sleep quality and energy levels, which together contribute to a better quality of life.

For women with a womb, Estradot is usually prescribed with a progestogen (e.g. Utrogestan) to protect the lining of the uterus and reduce the risk of endometrial cancer. This combination is known as combined HRT.

How Long Does Estradot Take to Work?

Everyone responds to HRT at a slightly different pace, but many women notice some improvement in their symptoms within the first few weeks of using Estradot. Hot flushes, night sweats and sleep disturbances are often the first to improve. In most cases, it can take around 6 to 12 weeks for Estradot to reach full effectiveness.

If symptoms persist beyond this point or you’re not feeling better, your dose may need to be adjusted.

How Effective is Estradot?

Estradot is a clinically proven and widely prescribed oestrogen patch. It’s considered
effective for treating vasomotor symptoms like hot flushes and night sweats, as well as improving sleep, mood, vaginal health and quality of life in menopausal women.

In a large-scale randomised controlled trial (RCT), which trialled over 60,000 women, those using transdermal estradiol patches like Estradot have reported:

• Reduced frequency and intensity of hot flushes
• Better sleep and improved energy levels
• Increased comfort during intercourse due to improved vaginal hydration
• Decreased joint pain and irritability

Estradot is also effective in helping prevent postmenopausal osteoporosis by maintaining bone density, particularly useful in women who are at higher risk of fractures.

The Benefits of Estradot Patches

Estradot offers several practical and medical advantages compared to other forms of HRT, such as oral medication.

The main ones include:

• Steady hormone release: Maintains a consistent level of oestrogen in your bloodstream, which may reduce the risk of side effects linked to hormonal fluctuations, such as nausea.
• Transdermal delivery: Absorbed through the skin, thereby bypassing the digestive system. This makes it suitable for women who can't tolerate oral HRT.
• Lower risk of blood clots: Compared to oral oestrogen, useful for women with risk factors. 
• Convenient and discreet: Applied twice weekly and worn under clothing, patches are fuss-free and don’t interfere with daily routines.
• Steady Libido: Oral oestrogen can lower libido by increasing sex hormone binding globulin (SHBG) levels. Transdermal oestrogen doesn’t have this problem. 
• No Stroke Risk: Transdermal oestrogen does not have an increased risk of stroke, unlike oral alternatives.

Perhaps one of the most significant benefits of Estradot patches is their rapid effectiveness. Relief of menopausal symptoms on Estradot can be achieved during the first few weeks of treatment, while some other options could take up to 3 months. 

Who Can Use Estradot Patches?

Estradot is suitable for most women experiencing menopausal symptoms who want relief through oestrogen-only HRT or combination HRT (with a separate progestogen).

Estradot may be a suitable option if you:

• Have perimenopause or postmenopause with moderate to severe symptoms
• Had a hysterectomy (and therefore don’t need added progestogen)
• Prefer a non-tablet option
• Have tried other forms of HRT and experienced side effects or poor results

Always discuss your medical history, lifestyle and any current medications with a prescriber before starting HRT.

Estradot Warnings and Contraindications

Estradot is generally well tolerated, but like all HRT products, it may not be suitable for everyone. You should not use Estradot if you:

• Have or have had breast cancer or another hormone-sensitive cancer
• Have undiagnosed vaginal bleeding
• Have a history of blood clots, stroke or heart disease
• Have liver disease
• Are pregnant or breastfeeding
• Suffer from porphyria

Your prescriber will also assess your risk of conditions like high blood pressure, migraines, or gallbladder problems, which may require extra monitoring or a different HRT approach. HRT is not used as a contraceptive.

Estradot and Utrogestan: A Powerful Combination for HRT

Estradot provides the oestrogen component of HRT, while Utrogestan (micronised progesterone) is often prescribed alongside it for women who still have a womb. This combination protects the uterine lining from becoming too thick, a known risk when taking oestrogen alone.

Many women prefer Estradot together with Utrogestan because it's body-identical/bioidentical, meaning the hormones closely mimic those naturally produced by the body. This makes it a popular option for women looking for a more natural-feeling HRT experience.

You can order Utrogestan capsules from Prescription Doctor as part of your combined HRT treatment plan. 

Estradot Patches: How to Apply

Apply Estradot patches to clean, dry skin on the abdomen, never the breasts. Press for 10 seconds for good adhesion. If a patch falls off, reapply it or use a new one. Stick a new patch on a different area of skin to avoid irritation, with an interval of at least a week between applications to the same site.

Estradot patches should be applied as soon as you open the sachet and remove the protective liner. It’s important that you don’t place them on oily or damaged skin, or near the waist, as tight clothing may dislodge them.

Once applied, you should wait around an hour for the Estradot patch to fully stick to the skin before taking part in any activity that could cause you to sweat. This reduces the risk of it peeling off. Once attached and secure, you can bathe, swim, exercise, or shower with confidence.

Another factor that determines how to apply Estradot is the frequency of your period. If they continue to occur regularly, you should use the patches between days 1 and 5 of your period. If your periods have stopped, are infrequent, or you’ve had a hysterectomy, you can use Estradot patches at any time.

How Long Do Estradot Patches Last?

Each Estradot patch is designed to last for three to four days. The patch slowly releases a steady dose of oestrogen through your skin into the bloodstream over this time. Using the patches as scheduled is important to maintain consistent hormone levels and prevent the return of symptoms like hot flushes or mood swings.

How Often Do You Change Estradot Patches?

Estradot patches are changed twice a week, usually every three to four days. For example, one patch on Monday and another on Thursday. Don’t leave a patch on longer than instructed, as it will become less effective and may cause irritation. Never overlap patches or wear two at once unless advised to do so by your clinician.

When it’s time to change your patch, peel it away from your skin from one edge until fully removed. Fold it in half so it sticks to itself and discard it in your household waste. If you have any sticky residue left on your skin, this can be removed using baby oil or something similar. 

How Long Do You Use Estradot Patches For?

There’s no one-size-fits-all answer. Many women use HRT for a few years to ease the worst of their symptoms, while others continue longer under medical supervision.

• Short-term Use: Often 1–2 years, especially for severe menopausal symptoms.
• Longer-term Use: May be suitable for women at high risk of osteoporosis or for those whose quality of life is significantly affected. 
• Premature & Early Menopause: Women who go through premature (stoppage of periods before the age of 40) or early (where periods stop before the age of 45) menopause will usually need to use some form of HRT until they reach 51.

Your treatment should be reviewed at least once a year. If symptoms return after stopping Estradot, restarting HRT may be an option depending on your health and personal preference.

Estradot Dosage Information

Estradot is available in different strengths, including 25, 50, 75, and 100 micrograms. This allows for flexible dosing depending on your symptoms and treatment goals. You’ll typically start on the lowest dosage possible (either 25 mcg or 50 mcg), based on the severity of your symptoms. Your prescriber may increase or decrease the strength based on how well you respond to the medication.

Your Estradot patch strength and schedule should be reviewed at least once a year to make sure it’s still working for you.

Estradot Side Effects

Most women tolerate Estradot well, but some experience side effects, especially in the first few weeks as hormone levels adjust. Potential Estradot side effects include: 
 

Speak to your clinician if you experience unexplained vaginal bleeding, persistent headaches, chest pain, leg swelling or sudden shortness of breath. For a full list of potential Estradot side effects, please refer to the Patient Information Leaflet. 

How Long Do Estradot Side Effects Last?

Most Estradot side effects are mild and temporary, settling anywhere within the first 6 to 12 weeks as your body adjusts to the hormone changes. Common symptoms like breast tenderness, headaches or nausea typically improve with time or slight dose adjustments.

If side effects persist beyond three months or begin to interfere with daily life, consult your clinician, as they may suggest adjusting your dose, switching brands, or adding a progestogen like Utrogestan if necessary.

How to Deal with Estradot Side Effects

Most side effects improve as your body adjusts within the initial months. Here’s what may help:

• Nausea or bloating: Apply the patch after meals or try a lower dose if symptoms persist. 
• Skin irritation: Rotate application sites and avoid areas with friction (like the waistband). 
• Breast tenderness: Wear a supportive bra and limit your intake of caffeine and salty foods.

Serious side effects are rare but should always be reported immediately. Regular reviews help ensure your treatment stays safe and effective.

Where Can I Buy Estradot Patches?

You can buy Estradot patches from a pharmacy or via a respected online service such as Prescription Doctor. In either case, you will need to obtain a prescription for the treatment from your GP or a licensed clinician. This is to determine whether the medication is suitable for your circumstances and medical history. 

Is Estradot Available Over the Counter?

No, Estradot is not available over-the-counter. The patches are classified as prescription-only medication, meaning you will need to obtain authorisation from a doctor or clinician before buying them. This can be done by making a GP appointment or by filling out an online medical questionnaire to assess your suitability for the treatment. 

Can You Buy Estradot Online?

Yes, you can buy Estradot online from a trusted service like Prescription Doctor. Simply answer a few questions, and our specialist team will take care of the rest. Here’s how our process works:

• Assessment: Complete our online questionnaire for our clinicians to review.
• Decision: Our team will either approve your order, recommend an alternative, or cancel it and issue a full refund. 
• Dispatch: If authorised, your item will be dispatched in plain, discreet packaging. Orders approved before 3pm on a weekday are also eligible for next-day delivery.
• Follow-Up: Our clinicians will regularly check in with you to assess progress and ensure everything is working as it should. They’re also on hand to answer any queries you may have. 

Can I Get Estradot Patches on the NHS?

Yes, you can get Estradot patches on the NHS. You will need to book an appointment with a GP, or you can also obtain them from a specialist nurse. If you do not have a valid exemption, you will typically have to pay the standard prescription charge for the product. 

Frequently Asked Questions About Estradot HRT Patches