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How to order
  1. Click on the green "continue to medical questions" button.
  2. Fill in our short consultation form.
  3. Choose delivery method and mode of payment.
  4. Our team of expert prescribers will assess whether medication is suitable.
  5. If you get the green light and it is deemed suitable, your order will be processed quickly and efficiently.
Confidential Service

Your privacy is important, Prescription Doctor are committed to keeping your details completely confidential.

This is why we also take steps to conceal your prescription products under two layers of packaging.

Delivery and Packing
Discreet Delivery?

We have a commitment to delivering a discreet service and understand your need for privacy. We ship all orders via a trackable courier using discreet, plain packaging.

Do I Need to Wait in All Day for Delivery?

Once your order is dispatched you will receive a tracking number via sms and email.

Do You Deliver on Weekends?

We deliver medications between Monday and Saturday. You can upgrade to Saturday delivery on Friday.

My Order Hasn’t Arrived What Should I Do?

You should receive a tracking number with your order which you can use this number to track your parcel online. This should give you a clear indication of where your parcel is. If you haven’t received your parcel in the time frame given by our couriers, contact your local depot to find out where it is. You can also contact our support team who will do this for you.

Can I Be Notified by Text?

On checkout you will be asked to leave your mobile number so our courier can text you about the delivery. This is also useful if the courier has problems finding your address. We will not use your mobile number for anything else.

Payment Methods
How Can I Pay for My Order?

You can pay for your order using credit, debit card or via bank transfer.

I Don’t Have a Credit Card, How Can I Pay?

If you don’t have a credit or debit card you can pay via bank transfer. We will give you a unique reference number at checkout along with details of how to make the transfer. Once the money has cleared in our account, we will process your order.

How Do You Keep My Details Safe?

We are a completely secure site and take many measures to ensure your details are kept safe. We understand that you have a right to extreme privacy when purchasing sensitive health medications. All information that you provide to us is stored on our secure servers. Any payment transactions will be encrypted using SSL technology.

Payment and refunds?

You can pay for your order using credit, debit card and bank transfer.

Card Payment: Please notify us that you wish to cancel your order. Your refund will show available In 1 - 3 days.

Bank Transfer: A member of our team will contact you requesting for your bank details. These details are only used to transfer the funds back into your account.

About Product
This content has been written and checked for quality and accuracy by
Mohamed Imran Lakhi Content Administrator GPhC: 2060586 Updated on: 28/06/2019 Next review: 28/12/2019

What is Zapain?

Zapain is a brand of co-codamol - an opioid analgesic (painkiller) which is combined with a non-prescription pain reliever (paracetamol) to provide more effective relief than either ingredients alone.

"Severe pain, which may come following a severe injury or an operation, requires stronger painkillers than paracetamol alone. Zapain contains two painkillers which work together to provide effective pain relief for patients in these kinds of situations" Mohamed Imran Lakhi, Superintendant Pharmacist.

Zapain tablets contains 30 mg of codeine and 500 mg of paracetamol which effectively reduce severe pain.

How does Zapain work?

Codeine in Zapain

the codeine in Zapain interacts with the central nervous system (CNS) to change the way the brain perceives pain. Zapain works by mimicking the action of pain-reducing chemicals, known as endorphins, which occur naturally in the brain and spinal cord.

The human body converts codeine into morphine, another type of opioid. Once converted, the morphine molecules latch onto the opioid receptors in the CNS. When codeine binds with the receptors, they send a pain-reducing message to the brain.

Paracetamol in Zapain

Paracetamol works in the central nervous system to relieve mild to moderate pain differently. This medicine inhibits the production of prostaglandins, which are naturally occurring chemicals that produce pain and inflammation at the site of injury or disease.

Together, codeine and paracetamol work better to provide pain relief than either medicine could provide alone.

All oral pain pills must be digested in the stomach before they begin to work. Patients typically experience relief in 30 to 45 minutes after taking a pill. Zapain is a slow release medication and can provide relief from pain for up to 6 hours.

What are the Uses, Dosage, Side Effects and Warnings?


Zapainis commonly used to treat severe pain. Our registered prescribers can determine the correct dosage for you based on the severity of your pain, source of pain and your medical history. If our prescribers determine that Zapain is not a suitable treatment for you, they may offer alternative treatments options.


Take the prescribed dose every four to six hours when necessary.

If you take more Zapain than prescribed or exceed the maximum quantity, consult a physician immediately even if you feel fine. Taking excessive amount of paracetamol can cause delayed onset liver damage. The risk of paracetamol overdose is greater in those with alcoholic liver disease.

If you go to the hospital, ensure you take the remaining tablets in the original packaging so that doctors know exactly what you have taken.

Side effects

As with all medications, Zapain may cause adverse side effects for some patients. Common side effects associated with Zapain include:

  • Constipation
  • Drowsiness
  • Nausea, vomiting, abdominal pain, anorexia, incontinence, diarrhoea, as these may be the result of bile or urinary duct spasms
  • Skin rash, itching
  • Sweating, facial flushing
  • Low body temperature
  • Dry mouth
  • Blurred or double vision, or other changes in vision
  • Pinpoint pupils
  • Malaise, tiredness
  • Headache
  • Fever
  • Dizziness, vertigo, light-headedness
  • Slow or rapid heartbeat, palpitations
  • Breathing difficulties
  • Low blood pressure, feeling faint upon standing from a seated or lying position
  • Confusion, anxiety, mood changes such as including depression, sadness, euphoria
  • Convulsions, hallucinations, nightmares, depression
  • Stomach cramps, enlargement of the spleen
  • Uncontrolled muscle movement or muscle rigidity
  • Pain or difficulty in passing urine
  • Increased or decreased urinary frequency
  • Decreased libido or potency, or weak erection in males
  • Decreased libido or potency, or weak erection in males
  • High blood glucose levels
  • Swelling of the lymph nodes
  • Kidney damage
  • Blood disorders, such as reduced platelets that increase the risk of bleeding or bruising, reduced white blood cells that increase the risk of infection, and a severe decrease in blood cells to cause weakness, bruising and increased risk of infection

Do not take Zapain if you are pregnant unless instructed to do so by your doctor.

Do not take Zapain while you are breastfeeding, as the codeine in this product passes into breast milk.

How Do I Take Zapain?

Adults should take one or two tablets every four to six hours with a glass of water.

Always take Zapain exactly as prescribed by our online prescriber. Check with your prescriber if you are not sure how to take Zapain.

Do not take more than two tablets at a time, or take more often than every four hours. 

Do not take Zapain for more than three days, as the risk of opiate addiction increases with prolonged use. If your pain does not improve after three days on Zapain, consult with your doctor.

Paediatric population

Zapain is not suitable for children. The metabolism of codeine is unpredictable in children and therefore should be avoided.

How do I store Zapain tablets?

Keep the medication stored out of sight and reach of children.

Do not store in locations where the temperature exceeds 25 degrees Celsius. Store this medication in its original packaging.

When you have finished with this medication, ask your pharmacist how to dispose of any unused tablets. To protect the environment, do not dispose of unused medication via household waste or wastewater.

Expiry dates

You can find the expiry date printed on the package. The expiry date on the package refers to the last day of that month. Do not take the medication after the expiry date.

Cautions and exclusions

to reduce your risk of drug interactions, tell our prescriber about all the medications you currently take. Inform our prescriber of any medical conditions you may have, as they may change the way Zapain works for you.

Zapain contains 500 mg of paracetamol and 30 mg of codeine phosphate hemihydrate. Do not take Zapain if you are allergic or intolerant to any of the ingredients listed within the patient information leaflet.

How does our service work?

Our company helps you find the pain reliever you need, safely and securely. We offer a private prescription service, and all of our orders are fulfilled by a UK-regulated pharmacy.

There are a number of alternative medicines to Zapain, such as:

Frequently asked questions

Is co-codamol the same as Zapain?

Co-codamol and Zapain both contain 30 mg of codeine phosphate and 500 mg of paracetamol, and are both intended to treat moderate to severe pain in adults.

A person who has trouble swallowing tablets or capsules may choose co-codamol effervescent over zapain.

Can I take codeine phosphate and ibuprofen together?

While it is generally regarded as safe to take zapain and ibuprofen together, you should always consult your doctor to ensure that no interactions occur while taking both products.

Can you drive after taking Zapain?

Opioid painkillers can have a lethargic effect which may hinder your alertness and ability to drive.

If you feel your concentration affected by the medication you are taking, it is strongly advised not to drive.

For more information, check out the laws on drug driving.

Why is Codeine Addictive?

Codeine addiction can be both physical and psychological. With repeated use, the body becomes accustomed to the drug. Withdrawal symptoms may occur once it is no longer present in your system. A psychological urge to recreate the feeling associated with codeine phosphate may remain long after the medication is gone.

If addiction is a concern, speak to your GP or visit for more advice.

Table of contents

What is Zapain?

How does Zapain work?

What are the uses, dosages, side effects and warnings?

How to take Zapain?

How to store Zapain?

Frequently asked questions

How does our service work?

Related information

What are the dangers of codeine?

How to treat sprains and strains

What's the right painkiller for me?

Treatment information

  • Product Name: Zapain
  • Manufacturer: Mercury Pharma
  • Active Ingredient(s): Paracetamol 500 mg and Codeine Phosphate 30 mg
  • Administration: Oral
  • Presentation: Tablets or Capsules
  • Available Strength: 30/500 mg
  • Exemption: Prescription only medication
  • Application: Men and women over 18
  • Dosage: Take one to two - every six to eight hourly as needed
  • Description: Pain Relief
  • Drug Class: Opioid (Analgesic)
  • Alcohol Consumption: Do not drink alcohol while taking Zapain.
  • When Pregnant: Do not consume Zapain
  • When Breastfeeding: Do not consume Zapain
Click here to view the Zapain - Patient Information Leaflet

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